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Biomedical subjects

S Lin

Publications and source records attributed to S Lin.

At least 271 records · Page 15Linked to original sources
PubMed1999

[Renal protective effect of valsartan in diabetic rats].

OBJECTIVE: To investigate the mechanism of valsartan in protecting the renal lesion of diabetic rats. METHODS: The following groups of rats were studied: normal control rats, streptozotocin diabetic rats and diabetic rats treated with valsartan (8 mg x kg(-1) x d(-1)). Mean arterial pressure, plasma glucose, serum insulin, serum creatinine, urinary albumin, ACE activity and Ang II concentration of kidney as well as profile of kidney hypertrophy were observed after 2, 4, 8 weeks of treatment, while TGF beta(1) mRNA expression of kidney cortex was assessed by Northern blot analysis, TGF beta(1), fibronectin and collagen IV expression were measured by immunohistochemistry. RESULTS: Serum creatinine level (P < 0.05), urinary albumin excretion and kidney hypertrophy index (P < 0.01) of valsartan treated group were significantly lower than those of diabetic untreated group. There was a significant increase in mRNA expression of TGF beta(1) and protein expression of of TGF beta(1) fibronectin and collagen IV in diabetic rats (P < 0.01). The expression of TGF beta(1) mRNA and protein (P < 0.01) as well as the protein expression of fibronectin and collagen IV (P < 0.05) in the valsartan group were much lower than that in the diabetic group. CONCLUSION: The results suggested that valsartan has some renal protective effect on diabetes in rats, partly through down-regulating TGF beta(1) expression and reducing deposition of glomerular ECM.

Animals↗
PubMed1999

[Early use of Chinese drug rhodiola compound for patients with post-trauma and inflammation in prevention of ALI/ARDS].

OBJECTIVE: To evaluate the effects of the Chinese drug rhodiola on the preventive treatment of acute lung injury (ALI) caused by post-traumatic/inflammatory and thoracic-cardiovascular operations. METHODS: 104 patients who coincide with their diagnosis and standard scale were divided randomly in to single number groups A(1), B(1), C(1) and D(1) (early preventive treatment group EG) and double number groups A(2), B(2), C(2) and D(2) (control group CG). The treatment of primary disease both in EG and CG was similar, but in EG four grams of rhodiola compound (RCO) were used every day for a period of 3-15 days since admission and 5-7 days after operation. The indicators related to ALI in each groups were measured. RESULTS: PaO(2), AaDO(2) and hemorheology were significant in EG than in CG (P < 0.05) or (P < 0.01). The complication rate of ARDS was decreased about of 50.0% in EG than in CG. CONCLUSIONS: Early use of RCO may protect against major risk factors of ALI/ARDS caused by massive trauma/infection and thoracic-cardio-operations.

Adolescent↗
PubMed1999

[Protection against synergistic hepatocarcinogenesis of hepatitis B virus expression and aflatoxin B1 by antioxidant 2(3)-tert-4 -hydroxyanisole (BHA) in HBV large envelope transgenic mice].

OBJECTIVE: To investigate the effects of 2(3)-tert-4-hydroxyanisole (BHA) on protection against synergistic hepatocarcinogenesis of aflatoxin B(1) (AFB(1)) and hepatitis B virus (HBV) expression in HBV large envelope transgenic mice. METHODS: Protective effects of dietary antioxidant BHA on life span was observed in 49 cases of HBV transgenic mice and 48 cases of non-transgenic mice by determinations of enzyme activities and liver MDA, and by direct detection of liver oxidative free radicals (OFR) using electron spin resonance (ESR). RESULTS: In the HBV transgenic mice which exposed to AFB1, the incidence of hepatocellular adenoma was 17% (2/12), but no carcinoma was found in BHA group. In the regular diet group, that was greater with 67% (6/9) of adenoma and 22% (2/9) of carcinoma. BHA could decrease significantly the concentrations of liver MDA and OFR, compared with those with regular diet. The activities of quinone reductase and glutathione S-transferase in liver cytosols increased by 3 - 7 times, as in the controls, in response to BHA. CONCLUSIONS: Addition of BHA to the diet resulted in significantly elevation of phase II enzyme activities in liver. BHA could directly eliminate liver OFR and inhibit growth of hepatocellular altered foci. These actions may effectively put off hepatocellular carcinogenesis in mice.

Aflatoxin B1↗
PubMed1999

[Induction of quinone reductase and glutathion-s-transferase by dimethyl fumarate in rats].

OBJECTIVE: To assess induction of quinone reductase (QR) and glutathion-s-transferases (GSTs) by dimethyl fumarate (DMF) in major viscera of rats. METHODS: Fodder fed to male Wistar rats was supplemented with 2.0% DMF, and blood specimens were collected form the rats 6 h, 24 h, 72 h, 1 week and 2 weeks after feeding, respectively, and then animals were killed. QR and GSTs activities were determined in rats' gland stomach, liver, lung, kidney and heart, and also QR, LDH and GPT activities in their sera were measured with enzyme dynamic methods. RESULTS: Administration of DMF for 24 h, 72 h, 1 week and 2 weeks in rats can significantly increase activities of QR and GSTs in their gland stomach, liver, lung and kidney, as compared with those in controls (P < 0.0001, or P < 0.01), and their serum QR also significantly increased (P < 0.0001, or P < 0.01). But, DMF had no effect on activities of serum GPT and LDH (P > 0.05). CONCLUSION: DMF is a potent induction agent for QR and GSTs in the gland stomach, liver, lung and kidney of rats, which suggests it will hopefully be a protective and antidotic agent against human antioxidant injury.

Animals↗
PubMed1999

[Efficacy of native carvedilol in patients with essential hypertension].

To compare the efficacy of native carvedilol(Cv) with native atenolol(At), we treated 80 cases of essential hypertension(stage I-II) for 4 weeks, using both open-test and double blind randomized imitative methods. The daily dose of carvedilol was 10 mg to 40 mg, and that of atenolol was 50 mg to 100 mg. Both drugs were given once daily. Out of 30 cases of Cv group, carvedilol showed significant efficiency in 20 cases, and was effective in 6 cases. The total therapeutic efficiency was 86.2% (26/30). In the double blind groups(25 patients in each group), those treated with carvedilol(Group A) had 21 effective cases(84.0%) while those treated with atenolol(Group B) had 18 effective cases(72.0%). A lower incidence of adverse effects was observed in carvedilol group. Dizziness occurred similarly in both drugs, but it lasted only a short time and could be tolerated. The recommended dose of 10-30 mg once daily would be appropriate. After treatment there was a significant reduction in blood pressure in both groups(P < 0.01). It suggests that native carvedilol is a safe and effective anti-hypertensive agent.

Adolescent↗
PubMed1999

[Determination of chlorogenic acid in chrysanthemum morifolium Ramat.flower].

OBJECTIVE: To determine the contents of chlorogenic acid in flower of Chrysanthemum morifolium. METHOD: Column: Nova-Pak C18, 4 microns, 4.6 mm x 250 mm, mobile phase: MeOH-0.1 mol.L-1 NaH2PO4(pH 2.65)30:70, detection wavelength: 328 nm. RESULTS: Flowers of 20 batches bought from the market were analysed. Contents of chlorogenic acid were 0.060%-0.467%. CONCLUSION: Chlorogenic acid is a suitable component for the quality control of C. morifolium.

Chlorogenic Acid↗
PubMed1999

[Determination of sarafloxacin by high performance liquid chromatography (HPLC)].

A method for the separation and determination of Sarafloxacin by HPLC was developed. The sample was dissolved in a mixture of V(acetonitrile):V(water) = 1:1. Operating conditions were as follows: mu-Bondapak C18 column (3.9 mm x 300 mm), V(acetonitrile):V(methanol):V(2 mmol/L H3PO4, adjust pH 3.5 with triethylamine) = 30:5:65 as mobile phase with a flow rate of 1 mL/min, UV detection at 278 nm, and column temperature was 15 degrees C. Under the above conditions, Sarafloxacin and other impurities were separated from each other. The method was simple, rapid, sensitive and accurate.

Anti-Infective Agents↗
PubMed1999

[Changes in chloroquine resistance of Plasmodium falciparum in Hainan province].

AIM: To observe the variation in resistance of Plasmodium falciparum after the cessation of chloroquine medication. METHODS: WHO standard in vitro microtest and in vivo test were used. RESULTS: In vitro test showed that the rate of chloroquine-resistant P. falciparum dropped from 97.9% in 1981 to 26.7% in 1997 (P < 0.001). The mean concentration of chloroquine for complete inhibition of schizont formation declined from 10.46 +/- 7.14 pmol/ul blood in 1981 to 1.63 +/- 1.47 pmol/microliter blood in 1997(P < 0.001). In vivo test showed that the rate of chloroquine-resistant P. falciparum decreased from 84.2% in 1981 to 18.4% in 1997(P < 0.001). The proportion of R III cases to the total resistant cases dropped from 53.1% in 1981 to 14.3% in 1997. CONCLUSION: A tendency of progressive decline of resistance of the parasite was revealed after the cessation of chloroquine medication.

Adolescent↗
PubMed1999

[Activated T lymphocytes in epiretinal membranes from eyes of patients with proliferative diabetic retinopathy].

PURPOSE: To investigate the potential contribution of immune-mediated processes to the development of proliferative diabetic retinopathy(PDR), an immunohistochemical study was undertaken to characterize the infiltrating immune cells in epiretinal membrances from the eyes of patients with PDR. METHODS: A total of 15 PDR epiretinal membrane specimens obtained surgically from pars plans vitrectomy were studied by using a panel of monoclonal antibodies against T lymphocytes (CD4), interleukin-2(IL-2) and interleukin-2 recpetors(IL-2R). RESULTS: Twelve of 15 specimens (80%) contained CD4-positive cells. IL-2 was found in 12 of 15 samples (80%), of which 11 also contained CD4-positive cells, and IL-2R was detected in 10 of 15 membranes(67%), of which 9 contained CD4-positive cells and released IL-2. Most of the IL-2R-positive membranes were from type I diabetic patients, 40% of them are younger than 40 years. CONCLUSION: Our study demonstrated the involvement of activated immune cells and release of lymphokine(s) in more than half of the diabetic epiretinal membranes tested and revealed that the processes of immune responses and the biological effects of lymphokines(s) may play an important part in the development of epiretinal membranes of PDR, especially in young-onset and type I diabetes.

CD4 Antigens↗
PubMed1999

[A new anaesthetic method of intraocular surgery: anaesthesia at infrafascia bulbi].

OBJECTIVE: To probe the advantage, indications and its mechanism of anaesthesia at intraocular operation with infrafaseia bulbi anaesthetic (IBA) technique. METHODS: 456 eyes were operated with the anaesthesia in infrafascia bulbi, including 77 eyes for phacoemulsification intraocular lens implantation, 346 eyes for modern surgical extracapsular cataract extraction and intraocular lens implantation, 33 eyes for trabeculectomy. 2 ml of mixture of 2% Lidocaine and 0.75% Bupivacaine were injected at infratemporal near bulbi conjunctiva of limbus through the blunt silicone canal, which entered the fascia bulbi via a small incision and reached the equator of the eyeball. When the injection of the mixture filled up the fascia bulbi the surgery could be performed. RESULTS: IBA applied in 456 eyes had shown the same effect as posterior fascia bulbar and peripheral fascia bulbar anaesthesia. IBA is a safe method. CONCLUSION: It is avoided the mechanical injure to optic nerve, artery, vein, muscle and wall of eyeball with IBA using blunt silicone injecting canal. It is proved in our clinical practice that this is a saft and efficient local anaesthetic method.

Aged↗
PubMed1999

[The design of a reflection sensor of NIRS tissue oximetry].

A design of the reflection light-electric Sensor suited to monitoring the statues of tissue blood oxygen on the surface of body is described. The designed sensors have been used too to detect blood oxygen statues of brain and muscle respectively, and many useful informations have been acquired Therefore The above-mentioned design is reasonalle and Feasikle.

Algorithms↗
PubMed1999

[The application of modularity design in the pulse oximeter].

This paper presents a thought of modularity design and application in our pulse oximeter and its hardware and software composition of the function board, the application can improve the reliability of the instrument greatly and make it easy to expand its function.

Equipment Design↗
PubMed1999

Comparison of bone mass in forearm, lumbar vertebra and hip by single and/or dual energy X-ray absorptiometry.

OBJECTIVE: Bone mineral density (BMD) was measured in normal Chinese women with single X-ray absorptiometry (SXA) and dual energy X-ray absorptiometry (DEXA). These two methods were compared to evaluate the sensitivity in reflecting bone loss. METHODS: Measurements were performed in 300 women aged 20 to approximately 79 (5 for each age). The 8mm distal, 1/4 distal, ultra distal site of the nondominant forearm were measured with SXA; the AP spine (L2-4), right femoral neck (Neck), Ward's triangle (Ward) and trochantor (Troch) were measured with DEXA. Ten women had 5 repeated measurements to evaluate the reproducibility of the equipments. RESULTS: The BMD peak for Neck and Ward was found between age 20 to approximately 29, for ultra distal and L2-4 at age 30 to approximately 39, for 8mm distal, 1/4 distal and Troch at age 40 to approximately 49. After reaching the peak values, BMD at all sites decreased with increasing age. The highest rate of yearly loss of BMD was at 8mm distal. Results of measurement showed significant correlation between SXA and DEXA. Comparing with premenopausal women, the bone loss rate in postmenopausal women was faster and highest up to 11 to approximately 15 years and the highest rate was at the Ward. CONCLUSION: The present study gives the normal values of BMD at seven sites for normal Chinese women. The ages of BMD peak were different at seven sites. The yearly loss of BMD was highest at 8mm distal, it seemed to be the sensitive region for bone loss with age. The postmenopausal women had highly significantly loss bone mass than the premenopausal women. Comparing with premenopause, postmenopause BMD for Ward's triangle with DEXA seemed to be most sensitive to the effect of menopause.

Absorptiometry, Photon↗
PubMed1999

[Determination of trace arsenic using GFAAS with metal-coated graphite tube].

The sensitivity, precision and disturbance-resisting property were studied by using metal-coated graphite tube for electrically heated atomic absorption spectrometry. The surface characteristic of the metal-coated graphite tube was studied by using X-ray diffraction meter and scanning electron microscope. The mechanism of satisfactory performance was discussed.

Arsenic↗
PubMed1999

[Studies on the infrared spectra of mico2-OR or micro2-SR-bridged double-cubane-like clusters containing MoFe3S4 cores].

The IR spectra of micro2-OR or micro2-SR- bridged double-cubane-like clusters containing MoFe3S4 cores (Et4N)3 [Mo2Fe6S8Cl6 (OMe)3] (1), (Et4N) [Mo2Fe6S8 (SPh)6 (OMe)3 (2), (Bu4N)3 Mo2Fe6S (SPh)6 (OMe)3] (3), (Et4N)3 [Mo2Fe6S8 (SBu(t))6(OMe)3](4), (Et4N)3[Mo2Fe6S8 (SPh)9](5) have been investigated. Their characteristic frequencies (v)Mo-micro2O(R), (v)Mo-micro2S(R), (v)Mo-S, (v)Fe-S*, (v)Fe-SR, (v)Fe-Cl were assigned by comparing their vibrational frequencies with their structural parameters and by comparing the IR spectra of them with that of the linear clusters. The electrophilic induced effects in different way and the relationship between deltav (i.e. (v)Mo-S* (v)Fe-S*) and Fe --> Mo charge transfer have been discussed. Finaly, the sameness and difference between the double-cubane-like and linear Mo-Fe-S clusters were demonstrated.

English Abstract↗