'Multidisciplinary appraisal of the British Institute for Brain Injured Children, Somerset, UK'.
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Brain Injuries↗
Biomedical subjects
S Lingham
Publications and source records attributed to S Lingham.
Local and systemic immune responses to pertussis infection and cellular and acellular vaccines.
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Adult↗
Computed tomography in non-specific mental retardation and idiopathic epilepsy.
In 29 children with mental retardation and infantile spasms, cranial computed tomography findings were abnormal in 75% and this finding may lead to modification of treatment or influence genetic counseling. In 41 children with mental retardation and other forms of epilepsy abnormal computed tomography findings were much less frequent and were not relevant to treatment.
Adolescent↗
An X-linked syndrome characterised by hyperuricaemia, deafness, and neurodevelopmental abnormalities.
Purine overproduction, with normal levels of the purine salvage enzymes, has been found in a 3-year-old boy and his mother. Both have high-frequency hearing loss from infancy. The child is hypotonic and shows locomotor delay. Two male siblings with similar neurodevelopmental problems died in early childhood. Biochemical studies suggest a combined syndrome associated with a superactive PP-ribose-P synthetase which in its severest form may produce neurodevelopmental complications, as well as uric-acid overproduction. Severe depletion of erythrocyte nicotinamide adenine dinucleotide and guanosine triphosphate appears to be associated with the neurological abnormalities and may be useful in diagnosis.
Adenine Phosphoribosyltransferase↗