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Biomedical subjects

S Liotet

Publications and source records attributed to S Liotet.

At least 19 recordsLinked to original sources
PubMed1994

Sjögren's syndrome diagnosis: a comparison of conjunctival and gingival impressions and salivary gland biopsy.

This study reviewed 43 patients with Sjögren's syndrome. All of the patients complained of either dry eye and/or dry mouth. Their clinical records were compared with results of three laboratory diagnostic tests to determine the most sensitive test. Out of 30 patients who complained of both dry eye and dry mouth, 10 had positive conjunctival impressions, 20 had positive gingival impressions and 24 had positive salivary gland biopsies. Of 5 patients who suffered from only dry mouth, 2 had positive conjunctival impressions, 3 had positive gingival impressions and 3 had positive salivary gland biopsies. Of 7 patients with only dry eye complaints, there were 3 positive conjunctival impressions, 5 positive gingival impressions, and 6 positive salivary gland biopsies. Out of 6 healthy controls without complaints of dry eyes/mouth, there were no positive conjunctival impressions, 4 positive gingival impressions, and 5 positive salivary gland biopsies. Gingival impression appears to be nearly as sensitive as salivary gland biopsy in this group of patients suffering from Sjögren's Syndrome.

Biopsy↗
PubMed1992

Biological modifications of the vitreous in intraocular parasitosis: preliminary study.

In intraocular parasitosis the immunologic reactions in the vitrectomy-fluids depend on the parasitic agent: there is a lymphocytical reaction without any IgE production in toxoplasmic chorioretinitis, whereas there is a strong hypersensitivity reaction with a local IgE production as well as the presence of eosinophils and an antigenic stimulation in fluids with toxocara parasitosis. The electrophoretic patterns are quite similar in both cases.

Adolescent↗
PubMed1991

Factors responsible for tear ferning.

The biochemical agents involved in fern formation on drying tears were investigated by studying the different patterns of ferning of tears from normal and pathological eyes, mucus glycoprotein, saliva, serum, and various salt solutions. We conclude that the ferning phenomenon observed when a drop of tears is allowed to dry at room temperature on a clean microscope slide is to a large extent determined by the electrolyte concentration, especially the ratio of monovalent sodium and potassium ions to divalent calcium and magnesium ions. The presence of a biopolymer is essential, but this need not specifically be mucus as previously thought. The test may therefore be useful clinically in indicating the need for further tear analysis.

Electrolytes↗
PubMed1988

[Blood histamine levels in patients infected with the human immunodeficiency virus].

Serum histamine levels are significantly lowered in patients with human immunodeficiency virus (HIV) infection. Treatment with zidovudine has no effect on histaminaemia, but HIV-positive patients with thrombocytopenic purpura who underwent splenectomy are known to have had a rise in serum histamine levels after the operation. This parameter might be used as prognostic factor in the evaluation of patients with HIV infection.

HIV Seropositivity↗
PubMed1987

Electron microscopy of three cases of choroid malignant melanomas.

Ultrastructural study, by Scanning and Transmission Electron Microscopy, of three choroidal melanomas allows us to depict main features and cellular types of melanomas and to discuss our results with precedent studies. One case of balloon-cell tumor shows an unusual (from unknown genesis) substance, intra- or extracellularly located, but always near pigment cells expansions.

Aged↗
PubMed1987

Tear electrophoretic changes in Nigerian children after measles.

At the laboratory of the National Centre of Ophthalmology, Paris, tear electrophoresis on cellulose acetate support was studied in 56 Nigerian children--32 during and shortly after measles infection and 24 healthy controls. The controls had a normal pattern, while those with measles had patterns consistent with inflammation, most severe in the first week but showing varying degrees of recovery by the third week. Four weeks after measles all cases suffering from malnutrition had patterns with an additional peak. This was shown on further investigation by electrophoresis on polyacrylamide cellulose gel and immunoelectrophoresis to be due to serum transferrin. The normal protein pattern of tears is shown to be altered during and after measles infection.

Child, Preschool↗
PubMed1987

An interesting use of the study of tear ferning patterns in contactology.

A study of tear ferning patterns in normal and keratoconjunctivitis sicca eyes led to the classification into 4 types by Rolando [1984]. We practised this in our laboratory and observed specific and distinct tear ferning patterns for electrophoretic types 1 and 2 which Liotet et al. [1983] described as abnormal tear proteins modification found in patients who repeatedly and rapidly clog their hydrophilic lenses. In a general way, a study of tear ferning patterns can result in an appreciation of tear quality in contactology.

Contact Lenses↗
PubMed1987

A new hypothesis on tear film stability.

Classically, the stability of the lacrimal film is due to the surfacing of the epithelial surface by the mucus produced by the goblet cells. However, there are many objections to this hypothesis. Deducing from electron microscopy of the epithelial cells, which shows vesicles in the superficial layer and glycocalix threads on the microvilli and other clinical facts, we think that the surfacing agent is not mucus but glycocalix. The disappearance of goblet cells during sicca syndrome is not the cause but the result of the dryness. Epithelial cell integrity is essential for the stability of the tear film and therapeutics must aim at regenerating these cells rather than only replacing the lacrimal film by tear substitute.

Conjunctiva↗
PubMed1987

[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos].

In the control subject, the thyroidal hormones have been found to be always present in similar quantities in both eyes tears. The proportion of T3 is much more important in the tears (23-40%) than in the plasma (1-2%). It is close to the concentration of deiodinated T4 found in many tissues. In ocular tissues, the T3 is thus very little or even not broken down. This led us to define the tear plasma relationship parameters. We studied lacrimo-plasmatic thyroidal parameters in cases with thyroidal dysfunction without ocular affection: 3 cases of hyperthyroidism, and 2 of hypothyroidism, to study modifications in case of endocrinal problems only. We also studied various types of exophthalmos: 31 cases of endocrine exophthalmos, whether the thyroidal plasma values were normal or not, and 2 cases of exophthalmia with expansive orbital hyperplasia in which there had been no previous thyroidal disturbance. An exophthalmia patient studied, including those with expansive orbital tissue, important changes, specific enough were associated in the tear/plasma parameters, correlated with the changes in the retro-orbital muscular tissues or fat detected by scanning. The study of these parameters, lacrimal thyroid is thus interesting for the diagnosis of endocrine exophthalmos and shows that only a local modification of the metabolism of T3 and T4, mainly from deiodination , process is probably implied in the pathology of these exophthalmos.

Adult↗