Retrospective study of hyperabnormal (supranormal) electroretinographic responses in 104 patients.
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Adolescent↗
Biomedical subjects
S Logani
Publications and source records attributed to S Logani.
Gamma Knife radiosurgery in the treatment of ocular melanoma.
Ocular melanoma, the most common primary adult intraocular neoplasm, has a very high morbidity and mortality despite multiple alternative therapies. Consequently, we decided to study Gamma Knife radiosurgery (GKR) for the treatment of ocular melanoma in a clinical trial format. We describe the modifications of standard GKR to treat intraocular tumors, the objective, inclusion and exclusion criteria, treatment parameters, measurement of effect, and statistical evaluation of the clinical trial. The major adverse effects (i.e., cataract, vitreous hemorrhage, blindness, and loss of the eye) of the study are correctable or infrequent, whereas the benefits (i.e., tumor stasis or regression, preservation of sight, lower metastatic potential, and preservation of the globe) are substantial. This study is designed to evaluate GKR as a treatment option for ocular melanoma, although results are not yet available.
Adult↗
Resolution of choroidal metastasis in breast cancer with high estrogen receptors.
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Antineoplastic Combined Chemotherapy Protocols↗
Optic disk size in ischemic optic neuropathy.
We measured the horizontal diameter, vertical diameter, and area of the optic disk in fellow eyes of patients with unilateral nonarteritic ischemic optic neuropathy and in control eyes without ocular disease. The fellow eyes of patients with anterior ischemic optic neuropathy had a smaller horizontal than vertical disk diameter (P less than .05), a difference not present in controls. Both the horizontal disk diameter and the disk area were significantly smaller in fellow eyes of patients with anterior ischemic optic neuropathy than in controls (P less than .05). There was no statistical difference in the vertical disk diameters between the two groups. Our findings suggest that a small disk area along with a horizontal shortening of the scleral canal can lead to crowding of optic nerve fibers, predisposing to a circulatory compromise of the optic nerve head in non-arteritic anterior ischemic optic neuropathy.
Adult↗
Cotton-wool spots in acquired immunodeficiency syndrome compared with diabetes mellitus, systemic hypertension, and central retinal vein occlusion.
The cotton-wool spot is a common fundus finding in patients with many ocular and systemic diseases. We investigated the characteristics of cotton-wool spots in patients with four major diseases, ie, acquired immunodeficiency syndrome, diabetes mellitus, systemic hypertension, and central retinal vein occlusion, to see if any differences were detected in their number, size, or location. A composite of all the cotton-wool spots for each of these four categories was obtained by computed reconstruction to analyze variations in their distribution and size. The cotton-wool spots had a predilection for the temporal quadrants in the four categories and were smaller in patients with acquired immunodeficiency syndrome than the other groups. Patients with ischemic central retinal vein occlusion had more cotton-wool spots than the other groups. No other definite differences were detected. Cotton-wool spots than the other groups. No other definite differences were detected. Cotton-wool spots seem to be a common pathway following various insults to the retina, most probably of a vaso-occlusive origin.
Acquired Immunodeficiency Syndrome↗
Nd:YAG laser photodisruption of the lens nucleus before phacoemulsification.
We studied the use of Q-switched Nd:YAG laser pulses to soften sclerotic lens nuclei before phacoemulsification. We obtained 105 lens nuclei from extracapsular cataract extractions, graded them for degree of sclerosis, and randomized them into laser treatment (53 lenses) or control groups (52 lenses). The treated lenses received laser pulses until confluent pits and clefts were visible. All lenses were phacoemulsified and the times recorded. Nd:YAG laser pretreatment decreased phacoemulsification time in all grades. In moderately sclerotic nuclei, average phacoemulsification time was reduced from 40.1 to 23.9 seconds (40.4%). The nuclei of ten lenses obtained from intracapsular cataract extractions were treated intracapsularly, and the posterior capsule was inadvertently ruptured in five.
Cataract Extraction↗