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Biomedical subjects

S Lou

Publications and source records attributed to S Lou.

26 records · Page 2Linked to original sources
PubMed1993

[What has the reform of primary care meant in the community approach to arterial hypertension?].

OBJECTIVE: To evaluate an arterial Hypertension programme (AHP), with analysis of its feasibility and the problems inherent in the methodology used. DESIGN: A retrospective evaluation of the results of an AHP programme. A population projection of the results by means of an extrapolated calculation. SETTING: An urban Health Centre. PATIENTS: A random sample of 282 patients selected from the total of 564 individuals diagnosed with AHT over the 6 years of the programme's operation. MEASUREMENTS AND MAIN RESULTS: The 564 patients in the records made up 16.5% of the Health Area's adult population. The iceberg phenomenon (the percentage of undiagnosed hypertension sufferers) has evolved from 59% in 1988 to the present 17%. 7.4% of the sample received no treatment. Average AHT figures for the patients in treatment were 143 +/- 15 mm Hg systolic pressure and 85 +/- 9 mm Hg diastolic. 75% had adequate control of their tension figures (< 160/95). The population projection of these findings indicated that 57% of Hypertension sufferers calculated to be living in the Health area were diagnosed and monitored. CONCLUSIONS: The results show that the AHT situation among the population has substantially improved. The methodology used is easy to manage and can be of service in the evaluation of the impact of AHT programmes on the population.

Adult↗
PubMed1992

[Pharmacokinetics of liensinine in rabbits].

A method for the determination of plasma concentration of liensinine with HPLC and pharmacokinetic study of liensinine in rabbits were reported. Assay linearity was shown over the range of 0.125-2.5 micrograms/ml serum with regression coefficient of 0.9997. The mean recoveries of liensinine in plasma (within-day and between-days) were all more than 99% of the dose and the coefficients of variation were less than 5%. After a single intravenous injection of liensinine 6mg/kg to rabbit. The pharmacokinetic characteristics were found to fit a two-compartment open model. Important parameters were: t1/2 alpha = 8.303 min t1/2 beta = 129.960min AUC = 132.67 micrograms.min/ml CL = 0.045 L/min Vc = 2.768 L/kg.

Animals↗
PubMed1992

[Pharmacokinetics of sinomenine by HPLC].

Pharmacokinetics of sinomenine in rabbit was studied by reverse-phase HPLC method. After i.v. injection of 20 mg/kg of sinomenine to rabbits, the pharmacokinetic characteristics were found to fit a two-compartment open model.

Animals↗
PubMedDate not supplied

Cyanide self-addition, controlled adsorption, and other processes at layered double hydroxides.

Layered double hydroxides (LDH) are anion-exchanging materials of the type M(III)-M(II)x(OH)(2x + 2)Y that occur abundantly in nature, and can concentrate, protect, and activate simple organic anionic species of possible relevance to the earliest organisms. We now wish to report progress in the following areas: 1) Internal vs. external uptake of anions. Ferrocyanide does not displace carbonate from synthetic hydrotalcite (Mg:Al LDH carbonate) but is nevertheless taken up on the outside of the particles. In other cases, anion uptake is controlled by specific hydrogen bonding requirements rather than by charge density alone, a feature that can be used to control whether uptake will be both internal and external, or external only. These two findings taken together have important implications for specific catalysis by LDH, since specific hydrogen bonding will affect the individual and relative conformations of substrate anions, and anions occupying space in the interlayer will be under tighter constraints than those adsorbed externally. 2) Specific reactions catalyzed by LDH. We have found that the LDH Mg2Al(OH)6Cl catalyzes the self-addition of cyanide, to give in a one-pot reaction at low concentrations an increased yield of diaminomaleonitrile and in addition, at higher (> or = 0.05 M) concentrations, a purple-pink material that adheres to the LDH. We are investigating whether this reaction also occurs with hydrotalcite itself, what is the minimum effective concentration of cyanide, and what can be learned about the products and how they compare with those reported at high HCN concentrations in the absence of catalyst.

Adsorption↗