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S Louw

Publications and source records attributed to S Louw.

9 recordsLinked to original sources
PubMed2002

Active haptic detection and discrimination of shape.

In previous research, we have shown that detection thresholds for Gaussian shapes increase with a power of 1.3 of spatial width. In the present three experiments, we generalized this finding to more complex shapes and to discrimination tasks. In Experiment 1, we found that the slope of the psychometric function for detection (i.e., distinguishing curved from flat surfaces) was independent of surface shape. In Experiment 3, we found the same result for discrimination of two different curved shapes. In Experiment 2, we found that detection and discrimination functions had the same dependence on spatial width, except that discrimination thresholds were two to four times larger. Possible neural mechanisms underlying these results are discussed.

Discrimination, Psychological↗
PubMed2000

Haptic detection thresholds of Gaussian profiles over the whole range of spatial scales.

In the literature only a small subset of the broad range of scales of human haptic perception has been explored. In this experiment, haptic detection thresholds have been investigated over a wide range of spatial scales. Computer-controlled manufacturing techniques have made it possible to produce stimuli with sufficient accuracy to explore the gamut of haptic scales. We used stimuli with a convex or concave Gaussian-shaped profile running over the middle of a strip. The width of the Gaussian profile was varied between 150 microns and 240 mm. In this range of spatial scales a number of mechanisms, ranging from cutaneous mechanoreception to proprioception in fingers, arm and shoulder, contribute to haptic perception. The discrimination threshold between a flat surface and a Gaussian surface was investigated in a series of two alternative forced choice experiments on human subjects. The thresholds run from 1 micron for the narrowest Gaussian profiles to 8 mm for the broadest profile. The same thresholds were found for convex and concave shapes. Over the range of spatial scales, from 1 mm width on, the dependence of the detection threshold on the spatial width of the Gaussian profile was found to be a power function with an exponent of about 1.3.

Discrimination, Psychological↗
PubMed1992

IgM rheumatoid factor removal and performance of the FTA-ABS (IgM) test in congenital syphilis.

OBJECTIVE: To determine the performance of the FTA-ABS (IgM) test in congenital syphilis after eliminating interference by IgM rheumatoid factor (RF) and preventing competitive inhibition by IgG. DESIGN: The FTA-ABS (IgM) test was carried out before and after RF removal (achieved by immunoprecipitation of the IgG) in infants with congenital syphilis and controls. SETTING: Newborns delivered in the Peninsula Maternal and Neonatal Services in Cape Town and infants presenting at Red Cross War Memorial Children's Hospital. SUBJECTS: Infants with congenital syphilis aged 0-4 months were divided into those with clinical signs at presentation and those who were asymptomatic at delivery. In addition, patients without congenital syphilis but with similar clinical signs at presentation were investigated as were control infants. OUTCOME MEASURE: The diagnosis of congenital syphilis was based on the criteria suggested by Kaufman et al (1977). RESULTS: Amongst symptomatic infants with congenital syphilis the FTA-ABS (IgM) test was positive in 34 (92%) of 37 cases prior to abolishing the RF effect and in 29 (78.4%) of 37 cases afterwards (p = 0.19). In 12 cases of congenital syphilis who were asymptomatic at birth, 10 had positive FTA-ABS (IgM) tests before RF removal and only three had positive tests afterwards (p = 0.006). False positive tests were not found amongst 15 symptomatic infants whose clinical features mimicked those of the infants with congenital syphilis. Among 51 healthy infants the test had a false-positive rate of 2% in newborns and 13% in older infants. The false positive reactions were eradicated by IgG precipitation. CONCLUSIONS: Following IgG and RF removal there was an improvement in the specificity of the FTA-ABS (IgM) test but this was at the expense of a loss of sensitivity, particularly in asymptomatic newborns. For newborns, if the FTA-ABS (IgM) test was positive, the patient was likely to require treatment for congenital syphilis, regardless of whether the result was due to the presence of RF or specific IgM.

Humans↗
PubMed1977

Multiple sclerosis in Coloured South Africans.

Detailed case histories of seven Coloured South Africans with multiple sclerosis are presented; the summary of one South African-born Indian is included. Apart from an isolated case report in 1947, this is the first time that multiple sclerosis has been reported in detail in this South African racial group. All the Coloured patients presented for the first time during the last 12 years.

Adult↗