Biomedical subjects

S Lupi

Publications and source records attributed to S Lupi.

15 recordsLinked to original sources

PubMed2006

Low-energy electrodynamics of superconducting diamond.

Heavily boron-doped, diamond films can become superconducting with critical temperatures Tc well above 4 K. Here we first measure the reflectivity of such a film down to 5 cm(-1), by also using coherent synchrotron radiation. We thus determine the optical gap 2Delta, the field penetration depth lambda, the range of action of the Ferrell-Glover-Tinkham sum rule, and the electron-phonon spectral function alpha2F(omega). We conclude that diamond behaves as a dirty BCS superconductor.

Journal Article↗

PubMed2005

Temperature dependence of the optical spectral weight in the cuprates: role of electron correlations.

We compare calculations based on the dynamical mean-field theory of the Hubbard model with the infrared spectral weight W(Omega,T) of La(2-x)SrxCuO4 and other cuprates. Without using fitting parameters we show that most of the anomalies found in W(Omega,T) with respect to normal metals, including the existence of two different energy scales for the doping and the T dependence of W(Omega,T), can be ascribed to strong correlation effects.

Journal Article↗

PubMed2005

Frequency-dependent thermal response of the charge system and the restricted sum rules of La2-xSrxCuO4.

In La2-xSrxCuO4 (LSCO) the spectral weight W=integralOmega0sigma(ab)1(omega,T)domega [where sigma(ab)1(omega,T) is the ab-plane conductivity] obeys the same law W=W0-BOmegaT2 as in a conventional metal such as gold, for any Omega up to the plasma edge. However, in LSCO BOmega points toward correlation effects and, unlike in gold, is related to an energy scale tT<<t0 approximately W0. The Ferrell-Glover-Tinkham sum rule is fulfilled in LSCO superconductors for Omega greater than or approximately equal to 2000 cm(-1).

Journal Article↗

PubMed2004

Non-smoking coke oven workers show an occupational PAH exposure-related increase in urinary mutagens.

We examined the urinary mutagenicity in the YG1024 Salmonella typhimurium strain in the presence of S9 mix, of 31 male non-smoking coke oven workers and an equal number of controls matched for gender and dietary habits. Occupational PAH exposure to the workers was assessed by means of the individual urinary post-shift excretion of 1-pyrenol (mean +/- S.D.: 5.41 +/- 6.06 micromole/mol creatinine). Eleven urinary extracts of workers (35.5%) were clearly mutagenic (with at least a doubling of the number of spontaneous revertants), against only two samples in the control group (6.5%) (chi2-test; chi2 = 7.883; P < 0.01). Moreover, the mean mutagenic activity level corrected for dilution/concentration of the urine was about three times higher in coke oven workers than in matched controls (mean +/- S.D. (range) 495 +/- 407 (89.7-1603) versus 186 +/- 113 (14.2-524) net revertants/mmol creatinine; Mann-Whitney U-test, z = 3.86, P < 0.001). Simple linear regression analysis showed that the coke workers' urinary mutagenic activity is associated with the PAH occupation-related urinary excretion of 1-pyrenol (r = 0.41, P = 0.0215). This study definitely demonstrates an occupation-related exposure of coke oven workers' bladder epithelium to mutagenic PAH metabolites. This factor, mainly in the case of high exposure studied here, may account for a higher bladder cancer risk in coke oven workers.

Coke↗

PubMed2003

Phase diagram of La2-xSrxCuO4 probed in the infared: imprints of charge stripe excitations.

While there is increasing evidence for antiferromagnetic (AF) ordering in the Cu-O planes of high-T(c) superconductors, either static or fluctuating, there is no direct evidence so far for the charge stripes that should separate the AF domains. By investigating the optical response of La2-xSrxCuO4 for 0<or=x<or=0.26 and 30<or=T<or=295 K, we identify strong far infrared peaks whose energy, width, and intensity are consistent with a scenario of charge stripe dynamics in the Cu-O planes.

Journal Article↗

PubMed2002

Role of metabolic polymorphisms NAT2 and CYP1A2 on urinary mutagenicity after a pan-fried hamburger meal.

In this work the phenotyping approach was used to study the influence of metabolic polymorphisms NAT2 and CYP1A2 on S9-mediated urinary mutagenicity, detected with Salmonella strain YG1024, in 50 subjects after a meal of pan-fried hamburgers. All 50 post-meal samples, but not pre-meal ones, were clearly mutagenic (number of urine samples able to double number of spontaneous revertants was 50 to 0, respectively). CYP1A2 positively influences urinary mutagenicity: a rise in CYP1A2 activity increases levels of post-meal urinary mutagens (1.16+/-0.91 vs 1.72+/-1.19 7-h minimum mutagenic doses (MMDs)/intake), especially in NAT2 slow acetylators (2.18+/-1.33 vs 0.90+/-0.54 7-h MMDs/intake, Mann-Whitney U-test, P<0.05). NAT2 rapid acetylators exert lower post-meal urinary mutagenicity than slow ones (1.41+/-1.02 vs 1.77+/-2.45 7-h MMDs/intake) and even more if the latter are extensive CYP1A2 metabolizers (1.41+/-1.02 vs 2.18+/-1.33 7-h MMDs/intake), but the difference did not reach statistical significance. In conclusion, this study indicates that CYP1A2 and NAT2 activities influence the presence of urinary mutagens after a meal of pan-fried hamburger (rich in HHAs) and consequently their potential genotoxic risk.

Adult↗

PubMed1998

SINBAD, a brilliant IR source from the DAPhiNE storage ring.

SINBAD is the Italian IR synchrotron radiation beamline, designed to work at wavelengths greater than 10 micro m. It is being installed on DAPhiNE, a new collider that is designed to work at 0.51 GeV with a beam current up to 5 A. Due to such a high current, the IR extracted from a bending magnet will be more brilliant than that of a black body at 2000 K by two orders of magnitude at 100 micro m. The beamline optical system, projected by ray-tracing simulation, consists of six mirrors that first focus the radiation on a wedged CVD diamond-film window and then transfer the collimated beam to the experimental area where a Michelson interferometer will be installed.

Journal Article↗

PubMed1996