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Biomedical subjects

S M Ashraf

Publications and source records attributed to S M Ashraf.

At least 19 recordsLinked to original sources
PubMed2006

Synthesis, characterization, antibacterial and corrosion protective properties of epoxies, epoxy-polyols and epoxy-polyurethane coatings from linseed and Pongamia glabra seed oils.

The aim of this paper is to investigate the structures and properties of epoxidized linseed and Pongamia glabra oils (LOE/POE), their derived products-epoxy-polyols (HLOE/HPOE), epoxy-polyurethanes (EU=LOPU/POPU) and EU coatings. Changes in epoxy equivalent, iodine value, hydroxyl value and percent saturation of oil backbone in due course of epoxidation and hydroxylation reactions, were plotted as a function of time. Spectral (IR, (1)H NMR and (13)C NMR), physico-chemical and thermal (TGA and DSC) analyses of aforementioned resins were performed by standard methods. Physico-mechanical and chemical resistance tests reveal that coatings of LOPUs perform better than those of POPUs. It was found that properties of oil epoxy-polyurethane coatings are mainly governed by: (i) fatty acid composition and nature of starting oils, (ii) extent of epoxidation, (iii) number and location of hydroxyls and residual double bonds in the final product and (iv) the presence of long dangling chains. PO, HLOE and LOPUs exhibit good antibacterial activity against Escherichia coli at very small MIC. These EU systems can be safely employed unto 220 degrees C.

Anti-Bacterial Agents↗
PubMed1997

Waterborne diseases of bacterial origin in relation to quality of water in a suburb of Uttar Pradesh.

Waterborne disorders of bacterial origin, e.g. typhoid, bacillary dysentery and diarrhea are one of the major global health problems, especially in developing countries like India. The prevalence of these diseases is largely dependent on the quality of water consumed by people. The quality of water in India is still below the WHO recommendation of zero fecal coliform/100 ml of water. The present study was conducted in a suburb of Aligarh District of U.P. (India). A total of 1270 persons were selected by paying home visits and followed up for a period of one year. The study revealed that morbidity was higher in standpost group, i.e., 88.3% while in piped water group it was 51.8%. The average episode of typhoid for both source of water was one while dysentery had 3 average episodes. The average episodes of diarrhea was 4 in stand post and 3 in piped water group. In standpost group the majority of people, (87.6%) were using unsatisfactory water as compared to 74.4% for piped water supply. The frequency of typhoid was 1.4% bacillary dysentery 3.4% and diarrhea 7.7%. The occurrence of waterborne disorders of bacterial origin was common for typhoid in the 5-12 years age group bacillary dysentery for the 1-5 years, and diarrhea for the 0-5 years age group. The morbidity rate in standpost group was comparatively higher, i.e., 79.6%. The frequency for the standpost group and piped water group for different diseases were, typhoid 1.1% and 0.7%, bacillary dysentery 2.7% and 2.2%, and diarrhea 6.1% and 5.1%, respectively.

Adolescent↗
PubMed1995

Interaction of decavanadate polyanions with proteins.

The binding of polymeric decavanadate anion [V10O28]6- with bovine serum albumin and gelatin was studied at pH 4.0 and 3.0, the region of thermodynamic stability of oligomeric vanadate anion. The binding of decavanadate anion at pH 4.0 with bovine serum albumin (BSA) and gelatin was found to be 9 and 32 gmol of decavanadate per gram mole of the proteins. The binding at pH 3.0 was found to be 12 and 38 gmol, respectively. Freshly formed BSA decavanadate precipitate was particulate in nature while that of gelatin-decavanadate made a gummy mass. This indicates a different mode of binding of decavanadate anions with globular and fibrillar proteins. Infrared spectra of the adducts endorses electrostatic binding between proteins and decavanadate. Scanning electron microscopy micrographs reveal extended crosslinked binding between decavanadate and gelatin and aggregation of the uncharged BSA-decavanadate molecules to make a granular adduct. The mode of binding was also correlated with the structure of decavanadate anions, BSA, and gelatin.

Animals↗
PubMed1994

Effect of acute occlusion of left renal vein on the kidney: an experimental study in dogs.

To study the effects of acute ligation of the left renal vein an experimental study was carried out on 16 Mongrel dogs out of 18 of which 2 had died postoperatively. The right kidney served as control. Changes immediately after ligation were recorded; subsequently the dogs were sacrificed in 4 groups comprising 4 in each at intervals of 24 hours, one week, 4 weeks and 6 weeks. Both the kidneys were removed and gross and microscopic changes were noted. In all cases atrophy of the ligated kidney due to tubular atrophy and fibrosis were seen in spite of good collaterals. It is concluded that left renal vein ligation in dogs is not safe for the kidney, though it is not fatal.

Acute Disease↗
PubMed1992

Morphological changes in diseased gall bladder: a study of 415 cholecystectomies at Aligarh.

Morphological changes of gall bladder were studied in 415 cholecystectomy specimens. There was a preponderance of females (male to female ratio--1:6.5). The mean age of the cases was 43.6 years. Most of the cases (63.4%) were in the 4th and 5th decades of life. The average duration of illness was 2.8 years. Associated cholelithiasis was present in 85.3% cases. Gall-stones were of mixed variety in 78.2% cases, cholesterol type in 15.3% cases and both types were present in 6.5% cases. Chronic cholecystitis was the main histological diagnosis (50.8%). Other lesions observed were adenomyomatosis (8.2%), adenomatous hyperplasia (10.1%), granulomatous cholecystitis (4.1%), cholesterosis (2.7%), acute cholecystitis (4.1%), acute on chronic infection (10.8%), sub-acute cholecystitis (2.4%) and carcinoma gall bladder (6.8%). The frequency of Rokitansky-Aschoff's sinuses was closely related with the degree of inflammatory response. In 13 (6.2%) cases the diagnosis of chronic follicular cholecystitis was made. All the cases of cholesterosis were multiparous females and of younger age. Of the malignant lesions, adenocarcinoma was the commonest (96.4%).

Adult↗
PubMed1992

Primary malignant lymphoma of the gastro-intestinal tract: a clinicopathological study of 24 cases.

Twenty-four cases of primary lymphoma of the gastro-intestinal tract were diagnosed during the period 1970 to 1991. There was a preponderance of males and the male to female ratio being 1.4:1. Age ranged from 9-70 years, mean 32.2 years. Small intestine was involved in 50% cases, large bowel in 9 cases (37.5%) and stomach in 3 cases (12.5%). There were 5 cases (20.8%) of Hodgkin's disease and 19 cases (79.2%) were of non-Hodgkin's lymphoma. All cases of gastric lymphoma complained of epigastric pain, weight loss and vomiting. In lymphoma of small intestine, 8 patients complained of pain associated with vomiting and 6 patients complained of distension of abdomen. In large bowel lymphoma, pain in right iliac fossa was complained by 4 patients and bleeding per rectum by 3 patients. Out of all the 24 cases, changes in bowel habit were noted in 15 patients and occult blood was positive in 13 cases. Palpable abdominal mass was noted in 14 patients. Histomorphologically, all the 3 cases in the stomach were of lymphocytic lymphoma diffuse type. Out of 19 non-Hodgkin's lymphoma, 15 were of lymphocytic lymphoma and 4 were of histiocytic lymphoma.

Adolescent↗
PubMed1991

Chronic granulomatous cholecystitis: a clinicopathological study of 17 cases.

In a clinicopathological study of 376 cases of gall bladder diseases, chronic granulomatous cholecystitis was diagnosed in 17 specimens (4.52%). All these cases presented with pain in the right hypochondrium and a non-functioning gall bladder. Besides cholegranulomas and xanthogranulomas, 5 cases presented with localised yellowish brown areas in the wall of the gall bladder which revealed on histology proliferation of histiocytes containing abundant granular brown pigment (as seen in ceroid granulomas), intermingled with lymphocytes, plasma cells and occasional foreign body giant cells. The average age of the patients was 41.3 years. Cholelithiasis was present in 12 cases (70.6%). In one case the gall bladder was bilocular, having granulomatous lesion on one side of the septum and papillary adenocarcinoma on the other side.

Adult↗
PubMed1989

Interaction of vanadium(V) oxoanions with ovalbumin and transfusion gelatin.

Vanadate(V) anions have been found to modulate the activity of a large number of enzymes. To elucidate these interactions, a physico-chemical study of the binding of meta-vanadate(V) with two typical proteins ovalbumin and transfusion gelatin has been taken up. The binding has been investigated by polarographic method at pHs 7.5 and 9.3, and at 30 degrees C. Values of intrinsic association constant, standard Gibb's free energy change, and the number of amino acids involved in these bindings are reported. Analysis of the binding sites has been done.

Binding Sites↗