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S M Beiser

Publications and source records attributed to S M Beiser.

30 records · Page 2Linked to original sources
PubMed1967

Studies on human antibodies. V. Amino acid composition of antidextrans of the same and of differing specificities from several individuals.

Human dextran-antidextran-specific precipitates from individuals immunized with dextrans containing either one or two antigenic determinants, were analyzed for their content of various amino acids. Large differences in certain amino acids were found among alpha-(1 --> 6)-specific antidextrans. Wide variations were also observed in antidextran fractions from a given individual specific for alpha-(1 --> 6)- and alpha-(1 --> 2)-linked glucose residues.

Amino Acids↗
PubMed1967

Nuclear fluorescence employing antinucleoside immunoglobulins.

Fluoresceinated antinucleoside globulins were shown to react with the nuclei of L cells. The pattern of nuclear fluorescence was similar to the distribution of nuclear DNA. This reaction was shown to be specific by the following control experiments: 1. Absorption of the specific antibody from an antiadenosine globulin eliminated all fluorescence. 2. Treatment of the cells with nonfluorescent antiadenosine globulin, followed by staining with the fluorescent antiadenosine eliminated almost all of the fluorescence of the nucleus. 3. Treatment of the cells with DNase destroyed the ability of the nucleus to react with antiuridine fluorescent antibodies. 4. Fluoresceinated anti-BSA did not produce nuclear fluorescence. Nuclear fluorescence occurred only in cells harvested during the period of maximum DNA synthesis as measured by the uptake of thymidine. This correlates with the previously demonstrated specificity of the antibodies for denatured DNA.

Animals↗
PubMed1965

Relationship between the competence antigen and the competence-activator substance in pneumococci.

Tomasz, Alexander (The Rockefeller Institute, New York, N.Y.), and Samuel M. Beiser. Relationship between the competence antigen and the competence-activator substance in pneumococci. J. Bacteriol. 90:1226-1232. 1965.-Antisera prepared against pneumococci in their competent phase inhibit deoxyribonuoleic acid (DNA)-mediated genetic transformation as well as binding of radioactive DNA by the cells. The same sera do not inhibit transformation of competent Haemophilus influenzae and Bacillus subtilis cells, but transformation of a Streptococcus strain genetically related to pneumococci is inhibited. The kinetics of immune inhibition of transformation resembles the inactivation of bacteriophage by phage-neutralizing antisera. The appearance of the competence antigen on the surface of pneumococci can be induced by the competence-activator substance. Antisera prepared against competent pneumococci can also inhibit the conversion of incompetent cells to competence by the competence-activator substance. The possibility is considered that part of the new antigenic determinant appearing on the cell surface during competence may be the activator itself.

Antigens↗