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Biomedical subjects

S M Breit

Publications and source records attributed to S M Breit.

2 recordsLinked to original sources

A novel interpolation strategy for estimating subsample speckle motion.

Multidimensional, high-resolution ultrasonic imaging of rapidly moving tissue is primarily limited by sparse sampling in the lateral dimension. In order to achieve acceptable spatial resolution and velocity quantization, interpolation of laterally sampled data is necessary. We present a novel method for estimating lateral subsample speckle motion and compare it with traditional interpolation methods. This method, called grid slopes, requires no a priori knowledge and can be applied to data with as few as two samples in the lateral dimension. Computer simulations were performed to compare grid slopes with two conventional interpolation schemes, parabolic fit and cubic spline. Results of computer simulations show that parabolic fit and cubic spline performed poorly at translations greater than 0.5 samples, and translations less than 0.5 samples were subject to an estimation bias. Grid slopes accurately estimated translations between 0 and 1 samples without estimation bias at high signal-to-noise ratios. Given that the grid slopes interpolation technique performs well at high signal-to-noise ratios, one pertinent clinical application might be tissue motion tracking.

Algorithms↗

Familial occurrence of alpha 1-antitrypsin deficiency and Weber-Christian disease.

Severe panniculitis of the Weber-Christian type occurred in two brothers, both with marked alpha 1-antitrypsin (alpha 1-AT) deficiency and phenotype PiZZ. Studies of inflammatory and immunologic function were undertaken in these two patients as well as in a third brother with severe alpha 1-AT deficiency but without Weber-Christian disease. The findings of these investigations were suggestive of exaggerated immunologic and inflammatory function with enhanced lymphocyte responsiveness to phytohemagglutinin, enhanced activation of neutrophils and monocytes, and accelerated delayed hypersensitivity responses in all three subjects. This hyperreactivity may explain the apparent association of alpha 1-AT deficiency with Weber-Christian disease.

Adult↗