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Biomedical subjects

S M Cooper

Publications and source records attributed to S M Cooper.

At least 37 records · Page 2Linked to original sources
PubMed2001

The influence of the sex of the general practitioner on referral to a vulval clinic.

Two hundred consecutive patients attending a dermatology vulval clinic in two hospitals were identified retrospectively. The sex and status of the referring doctor and the sex of the registered general practitioner was recorded. The length of symptoms prior to referral was determined. Female doctors referred 63% of women, despite only 38% being registered with a female general practitioner. Women referred by their own female general practitioners had a shorter mean duration of symptoms (3.4 years) than those registered with a male doctor but referred by a female (4.2 years). This study confirms that female doctors refer the majority of patients with vulval problems. Women registered with a female general practitioner tend to be referred earlier.

Journal Article↗
PubMed2000

Spatial distribution of tropospheric ozone in western Washington, USA.

We quantified the distribution of tropospheric ozone in topographically complex western Washington state, USA (total area approximately 6000 km(2)), using passive ozone samplers along nine river drainages to measure ozone exposure from near sea level to high-elevation mountain sites. Weekly average ozone concentrations were higher with increasing distance from the urban core and at higher elevations, increasing a mean of 1.3 ppbv per 100 m elevation gain for all mountain transects. Weekly average ozone concentrations were generally highest in Cascade Mountains drainages east and southeast of Seattle (maximum=55-67 pbv) and in the Columbia River Gorge east of Portland (maximum=59 ppbv), and lowest in the western Olympic Peninsula (maximum=34 ppbv). Higher ozone concentrations in the Cascade Mountains and Columbia River locations downwind of large cities indicate that significant quantities of ozone and ozone precursors are being transported eastward toward rural wildland areas by prevailing westerly winds. In addition, temporal (week to week) variation in ozone distribution is synchronous within and between all drainages sampled, which indicates that there is regional coherence in air pollution detectable with weekly averages. These data provide insight on large-scale spatial variation of ozone distribution in western Washington, and will help regulatory agencies optimize future monitoring networks and identify locations where human health and natural resources could be at risk.

Journal Article↗
PubMed2000

Flegel's disease treated with psoralen ultraviolet A.

Flegel's disease is an uncommon condition which causes asymptomatic keratotic papules on the limbs. It usually develops in the fourth or fifth decade. Therapeutic options are limited to emollients, topical 5-fluorouracil and retinoids, but none of these treatments is consistently helpful. We report a patient with Flegel's disease who responded to psoralen ultraviolet A treatment.

Female↗
PubMed2000

Anthropometric and kinematic influences on release speed in men's fast-medium bowling.

The main aim of this study was to identify significant relationships between selected anthropometric and kinematic variables and ball release speed. Nine collegiate fast-medium bowlers (mean +/- s: age 21.0 +/- 0.9 years, body mass 77.2 +/- 8.1 kg, height 1.83 +/- 0.1 m) were filmed and reconstructed three-dimensionally. Ball release speeds were measured by a previously validated Speedchek Personal Sports Radar (Tribar Industries, Canada). Relationships between selected anthropometric variables and ball release speed and between kinematic variables and ball release speed were investigated using Pearson's product-moment correlation coefficients (r). A significant relationship was found between the horizontal velocity during the pre-delivery stride (r = 0.728, P < 0.05) and ball release speed (31.5 +/- 1.9 m(-1) s(-1)). We believe that the high correlation was due to the bowlers using techniques that allowed them to contribute more of the horizontal velocity created during the run-up to ball release speed. We also found that the angular velocity (40.6 +/- 3.4 rad x s(-1)) of the right humerus had a low correlation (r = 0.358, P > 0.05) with ball release speed. Although the action of the wrist was not analysed because of an inadequate frame rate, we found high correlations between ball release speed and shoulder-wrist length (661 +/- 31 mm; r = 0.626, P < 0.05) and ball release speed and total arm length (860 +/- 36 mm; r = 0.583, P < 0.05). We conclude that the variance in release speed within this group may be accounted for by the difference in radial length between the axis of rotation at the glenohumeral joint and the release point.

Adult↗
PubMed1999

Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

Autosomal dominant periodic fever syndromes are characterized by unexplained episodes of fever and severe localized inflammation. In seven affected families, we found six different missense mutations of the 55 kDa tumor necrosis factor receptor (TNFR1), five of which disrupt conserved extracellular disulfide bonds. Soluble plasma TNFR1 levels in patients were approximately half normal. Leukocytes bearing a C52F mutation showed increased membrane TNFR1 and reduced receptor cleavage following stimulation. We propose that the autoinflammatory phenotype results from impaired downregulation of membrane TNFR1 and diminished shedding of potentially antagonistic soluble receptor. TNFR1-associated periodic syndromes (TRAPS) establish an important class of mutations in TNF receptors. Detailed analysis of one such mutation suggests impaired cytokine receptor clearance as a novel mechanism of disease.

Amino Acid Sequence↗
PubMed1999

5-Cyanovaleramide production using immobilized Pseudomonas chlororaphis B23.

A biocatalytic process for the hydration of adiponitrile to 5-cyanovaleramide has been developed which can be run to higher conversion, produces more product per weight of catalyst, and generates significantly less waste products than alternate chemical processes. The biocatalyst consists of Pseudomonas chlororaphis B23 microbial cells immobilized in calcium alginate beads. The cells contain a nitrile hydratase (EC 4.2.1.84) which catalyzes the hydration of adiponitrile to 5-cyanovaleramide with high regioselectivity, and with less than 5% selectivity to byproduct adipamide. Fifty-eight consecutive batch reactions with biocatalyst recycle were run to convert a total of 12.7 metric tons of adiponitrile to 5-cyanovaleramide. At 97% adiponitrile conversion, the yield of 5-cyanovaleramide was 13.6 metric tons (93% yield, 96% selectivity), and the total weight of 5-cyanovaleramide produced per weight of catalyst was 3150 kg/kg (dry cell weight).

Amides↗
PubMed1999

5-HT4 receptor antagonism in irritable bowel syndrome: effect of SB-207266-A on rectal sensitivity and small bowel transit.

BACKGROUND: Pre-clinical studies indicate that the 5-hydroxytryptamine (5-HT)4 receptor may be involved in the pathophysiology of irritable bowel syndrome and that antagonism of this receptor may be an effective therapeutic strategy. AIM: To investigate the effects of SB-207266-A, a selective 5-HT4 receptor antagonist on rectal sensitivity and small bowel transit in patients with irritable bowel syndrome. METHODS: Eighteen patients with diarrhoea-predominant irritable bowel syndrome and a history of increased rectal sensitivity were randomized to receive either SB-207266-A (20 mg) or placebo for 10 days. Following a washout period, patients were then crossed over to receive the alternative therapy for 10 days. Rectal sensitivity and orocaecal transit time were assessed on day 10 of each treatment period. In addition, patients were asked whether they had experienced any changes in their symptoms. RESULTS: Fifteen patients completed the study. SB-207266-A significantly increased orocaecal transit time towards normal (placebo: 5.3 h (4.0-7.2 h), mean (IQR) vs. SB-207266-A: 6.5 h (4.8-8.0 h); P=0.027) and tended to decrease rectal sensitivity (volume to discomfort 89 mL (60-150 mL), geometric mean (IQR) vs. 107 mL (75-150 mL); P=0.134). Eleven out of 15 patients reported symptomatic improvements with SB-207266-A but none with placebo. SB-207266-A was well tolerated. CONCLUSION: Our results support a role for the 5-HT4 receptor in the pathophysiology of irritable bowel syndrome and suggest that the selective 5-HT4 antagonist, SB-207266-A, is worthy of further evaluation in this disorder.

Adult↗