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Biomedical subjects

S M Drogovoz

Publications and source records attributed to S M Drogovoz.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[The efficacy of glucosamine in treating complicated hyperreactive experimental myocardial infarct].

The effect of glucosamine hydrochloride on the course of complicated hyperreactive myocardial infarction in dogs was studied. Glucosamine contributed to the restoration of reactivity in the animals. The reactivity became corresponding for normoreactive myocardial infarction. Glucosamine normalized carbohydrate and protein metabolism in the necrosis zone, cAMP and cGMP and also their ratio that led to healing by postinfarction scar, and in none of the cases the heart aneurysm developed. The optimizing healing of hyperreactive myocardial infarction under the influence of glucosamine is mediated through the mechanisms of reactivity and the regulation of metabolic processes.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[The influence of glucosamine on the antiexudative effect of nonsteroidal anti-inflammatory agents].

The study of the antiexudative activities of voltaren, indomethacin and piroxicam in combination with glucosamine on the model of carrageenan inflammation showed that the combination makes it possible to decrease the effective doses of nonsteroidal anti-inflammatory drugs by 2-2.7 times with the preservation of the pronounced antiexudative activity. A diverse influence of aminosugar on the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs depending on the sequence and routes of administration is connected with their membrane mechanisms and metabolic features of amino sugar.

Acute Disease↗
PubMedDate not supplied

[Physiologic importance of glucosamine].

The paper reviews the present state of the problem on the physiological importance of D-(+)-glucosamine, an amino sugar. Glucosamine is shown to be a component of many biological important systems widely spread in nature. It is a part of the connective tissues, membranes, lipopolysaccharides and mucopolysaccharides and participates in detoxic function of the liver and kidneys. The data from literature reviewed permit concluding that glucosamine and its derivatives are potentially useful and possess antiinflammatory, liver-defending, antihypoxic and other pharmacological activities.

Adult↗
PubMedDate not supplied

[The liver-protective properties of D-glucosamine].

The antioxidant and membrane-stabilizing activities of D-glucosamine were studied on two models of toxic liver damage. When administered in a dose of 50 mg/kg, D-glucosamine was found to prevent the development of the hepatocyte cytolysis syndrome, to normalize the cholate- and glycogen-synthetic functions of the liver. D-glucosamine exhibited a significant anabolic effect that also supplemented its hepatoprotective activity.

Animals↗
PubMedDate not supplied

[The hepatotropic properties of nonsteroidal anti-inflammatory agents].

The hepatotropic effect of nonsteroidal anti-inflammatory drugs (NSAID) such as indomethacin, voltaren, piroxicam, phenylbutazon, mefenamic acid was studied. It was found that according to their level of the pharmacological protection of the liver against tetrachlormethan these agents may be arranged in the following sequence: mefenamic acid, phenylbutazon, voltaren, piroxicam. The hepatoprotective effect of NSAID correlates with the antioxidant properties and fails to correlate with the antioxidant ones. The hepatotoxic effect of NSAID was determined by their ability to suppress synthesis of prostaglandins.

Animals↗
PubMedDate not supplied

[Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides].

The antiinflammatory activity and acute toxicity of 44 derivatives of heteryl amides of succinic acid (acids, esters, amides) were studied. This series of compounds was found to be promising for the search of nonsteroidal, practically nontoxic antiphlogistics. The structural-pharmacological analysis was performed and the dependence of the biological effect on the compound structure was revealed.

Animals↗
PubMedDate not supplied

[Disturbance of the intensity of secretion and chemical composition of bile in liver dystrophy induced by carbon tetrachloride].

Liver dystrophy induced by carbon tetrachloride results in inhibition of intensity of bile secretion and cholate formation and upsets discharge of bilirubin and cholesterol with bile. Inhibition of cholate synthesis might be accounted for by repressed production of deoxycholic and cholic acid from cholesterol as well as by repressed conjugation of cholic acid with taurine and glycine. Cessation of carbon tetrachloride injections is followed by steady restoration of bile formation: first of all is discharge of bilirubin restored, then discharge of cholesterol, and much later intensity of bile discharge and formation of bile acids.

Animals↗
PubMedDate not supplied

[Search for cholagogic preparations in a series of heterylamide derivatives of ethylene (ethane) dicarboxylic acids].

Study of the choleretic activity of heterylamides of dicarboxylic acids has demonstrated that search for choleretic drugs in this series holds promise. The relationship of the choleretic activity and toxicity to the chemical structure of the compounds has been shown with special reference to 10 compounds--the derivatives of ethylene (ethane)-dicarboxylic acids. It has been discovered that the occurrence of the choleretic action is essentially determined by the presence in the structure of the compounds of a free cyrboxylic group. It has been also demonstrated that etherification or amidation of this group or hydrogenation of the unsaturated bond lead to the reduction or complete loss of the choleretic activity.

Amides↗
PubMedDate not supplied

[An experimental study of suikrepan].

Acute, subacute, and chronic experiments were performed to examine the toxicity, specific action, analgetic, and physicochemical properties of suicrepan derived from the porcine duodenal mucosa and the hormone secretin contained in it. Suicrepan was found to be an effective pancreatic extrasecretory function stimulant, by showing therapeutical benefits in experimental pancreatitis and analgesic effects. The drug was demonstrated to display a low toxicity.

Acute Disease↗
PubMedDate not supplied

[The liver-protective properties of the pediatric drug form of propolis in animals of different age groups].

The pharmacological activity of a pediatric formulation of the phenolic hydrophobic drug propolis was studied in the experiments on albino rats of various age with toxic liver damages of various duration and in acute hepatic ischemia. In all models of hepatic abnormalities, the drug was found to show antioxidative properties which were moderate (30-60%). In addition, there were improvements in hepatic secretion of bile, cholic acids, and cholesterol. On the other hand, the membrane-stabilizing effect of the drug was exerted in not all the tested models of hepatic damage.

Acute Disease↗