Biomedical subjects

S M Farrar

Publications and source records attributed to S M Farrar.

3 recordsLinked to original sources

PubMed1989

Risk factors for the development and severity of glaucoma in the pigment dispersion syndrome.

The medical records of 93 patients with pigmentary glaucoma and 18 patients with pigment dispersion syndrome were studied with regard to factors associated with the presence and severity of secondary glaucoma within this population. Male gender, black race, severe myopia, and Krükenberg spindles were identified as possible risk factors. Men were predominant in this population 75 (67.6%); the diagnosis was made in men at an earlier age; they had a higher proportion in the glaucoma group; and they required more aggressive glaucoma therapy. There were only four black patients, but all required surgery. Patients in the glaucoma group had significantly more severe myopia and a higher incidence of Krükenberg spindles. These risk factors may help to identify which patients with the pigment dispersion syndrome require closer follow-up or the possible initiation of prophylactic therapy.

Adolescent↗

PubMed1989

An evaluation of the Tono-Pen for the measurement of diurnal intraocular pressure.

We evaluated the Oculab Tono-Pen for potential value in the measurement of diurnal intraocular pressure. Repeated recordings every ten minutes on the same eyes suggested that the instrument provides reproducible information. However, comparisons with Goldmann applanation tonometric measurements, in both single determinations and eight-hour diurnal recordings, showed considerable variation. Correction factors, using either the mean difference in paired readings from the single measurement study or individual differences from the initial set of diurnal recordings, did not eliminate this lack of correlation between measurements with the two instruments.

Circadian Rhythm↗

PubMedDate not supplied

Current concepts in pigmentary glaucoma.

Since its initial description over 50 years ago as a rare clinical entity, pigmentary glaucoma has become recognized as one of the most common forms of secondary open-angle glaucoma. Pigmentary glaucoma affects a much younger patient population than most other forms of open-angle glaucoma, and has a predilection for Caucasian males with myopia. Hallmarks of this disease include midperipheral iris transillumination defects, Krukenberg spindles and a heavily pigmented trabecular meshwork. The mechanism of pigment dispersion appears to be a rubbing between iris pigment epithelium and packets of lens zonules, possibly associated with an inherent abnormality of the pigment epithelium, and the mechanism of aqueous outflow obstruction is believed to involve accumulation of the pigment granules in the trabecular meshwork, followed by denudation, collapse, and sclerosis of the trabecular beams. Current management includes standard antiglaucoma drugs, laser trabeculoplasty, and filtering surgery, although research suggests the possibility of earlier intervention with medication or surgery to arrest the pigment dispersion and reverse or prevent the secondary glaucoma.

Adrenergic alpha-Antagonists↗