Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
S M Haumont
Publications and source records attributed to S M Haumont.
Thyroid gland in dwarf mice: a stereological study.
Stereological methods were used to compare thyroids of dwarf mice and of their heterozygote littermates. In the thyroid of dwarf mice unorganized cellular masses, adipous tissue and ultimobranchial cysts are abundant. Follicles are small and their distribution function is unimodal. The number of cells per follicle is considerably lowered if compared with the normal. In control mice the distribution function of thyroid follicles is bimodal. These data show that origin of the thyroid anomaly in dwarf mice is due to a drastic diminution of cell divisions, probably resulting from the lack of growth hormone.
Animals↗
Ultrastructure of the thyroid in dwarf mice.
The thyroid gland of Snell's dwarf mice consists of small follicles with flattened epithelium, partly differentiated cords and undifferentiated masses. Many adipocytes are found. The ultimobranchial cysts are well developed. Parafollicular cells are normal. In the partly organized cords, microfollicular cells are some small follicles limited by two or three cells are seen. The presence of these structures led us to think that they represent the first stages of normal folliculogenesis, described as the fusion of two adjacent unicellular microfollicles. Their further growth is the result of the coalescing of small adjacent follicles or of cellular multiplication. The presence of undifferentiated masses and partly differentiated cords, in dwarf mice, seems due to a developmental arrest rather than to aberrant development. This disorder of organogenesis is ascribed mainly to a lack of pituitary growth hormone.
Animals↗