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Biomedical subjects

S M Herber

Publications and source records attributed to S M Herber.

15 recordsLinked to original sources
PubMed1996

Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs.

Two experiments were conducted to investigate the usefulness of a natural golden marine algae (MA) as a poultry ration supplement for the production of shell eggs rich in n-3 fatty acids (n-3 FA). This MA is unique due to a high concentration of docosahexaenoic acid (DHA; C22:6n-3) and the absence of other n-3 FA normally present in marine oils such as menhaden oil (MO). In the first experiment, 60 24-wk-old Single Comb White Leghorn (SCWL) hens were divided among four dietary treatments, including a typical corn-soybean control (CON); 1.5% MO, supplying 233 mg eicosapentaenoic acid (EPA) and 155 mg DHA per d; 2.4% MA, supplying 200 mg DHA/d; and 4.8% MA, supplying 400 mg DHA/d. A second experiment using 96 56-wk-old SCWL was conducted using the same diets. In both experiments, eggs were collected weekly for 4 wk for determination of egg production parameters and yolk FA content. Each week, yolk samples were extracted, methyl estered, and quantified using gas chromatography. Transient depression in egg and yolk weights were noted early in Experiment 1 in response to dietary 4.8% MA. Although egg and yolk weights were not affected in Experiment 2, egg production was significantly reduced in the 4.8% MA treatment. Egg production was unaffected due to diet or week in Experiment 1. In both experiments, yolk polyunsaturated profiles were significantly influenced by diet. Dietary n-3 FA supplementation significantly increased yolk total N-3 FA with concomitant reductions in yolk n-6 FA. Although hens fed MO were supplied predominantly EPA, the principal yolk FA deposited was DHA. Marine algae also promoted efficient yolk DHA deposition with the highest yolk DHA concentrations attained in eggs from hens fed 4.8% MA. These data indicate that utilization of MA as a direct source of dietary n-3 FA may provide an efficient alternative to current sources of n-3 FA available for the production of poultry products rich in n-3 FA.

Animal Feed↗
PubMed1992

Height and body proportions in child abuse.

Abused children are said to retain 'infantile body proportions'. The presenting height, sitting height, and leg length standard deviation scores of 91 victims have been calculated from data derived from a study of local inner city schoolchildren. In the study population 31/91 (34%) were significantly short and all but two of these had relatively shorter legs than backs, this limb disproportion being significant in 17. In 25 patients of the original group followed up after various social interventions there was a significant recovery of leg length. Measurement of height and proportionality, especially when compared with appropriate modern or local standards, is an important means of detecting and following up victims of child abuse.

Adolescent↗
PubMed1988

Does control affect growth in diabetes mellitus?

Factors affecting the growth of 67 diabetic children were analysed retrospectively. The effects of age, sex, three year average glycosylated haemoglobin (HbA1) levels, time since diagnosis and age at diagnosis were assessed on the change in the child's height standard deviation score (SDS) over three years, as well as the change in height SDS from diagnosis. No correlation between these factors was noted over a three year period; however, there was a strong correlation (p less than 0.001) in the change in height SDS from diagnosis with the age of the child and time from diagnosis. Multiple regression analysis revealed that the younger the child at original diagnosis, the less the height SDS loss, and also that in younger children the age of the child and not the time from diagnosis was the more important variable in deciding the loss in height SDS. No correlation existed between HbA1 levels and either the short or long term growth of patients in this study.

Adolescent↗
PubMed1987

Sitting heights in Sheffield, 1985: have standards changed?

A community study was performed on 354 schoolchildren aged 4 to 13 years to assess whether the published UK standards for sitting height and leg length applied to the local population. The schoolchildren showed no significant difference from UK standards in standing height, but had significantly shorter sitting heights and significantly longer legs. When compared to children measured in several European studies, the Sheffield children had normal sitting: standing height ratios, whereas ratios from the published UK standards were significantly greater than those from the rest of Europe.

Adolescent↗
PubMed1987

Controlled study of exclusion of dietary vasoactive amines in migraine.

To assess the effects of dietary vasoactive amines in the aetiology of childhood migraine, 39 children were randomly allocated to either a high fibre diet low in these substances or a high fibre diet alone. Both groups of children showed a significant decrease in the number of headaches and there was no significant difference between the two groups. Dietary vasoactive amines have not been shown in this study to influence childhood migraine. The improvement seen in both groups emphasises the need for a control diet in studies designed to show that dietary manipulation improves disease.

Adolescent↗
PubMed1987

Aetiology of growth hormone deficiency.

A retrospective analysis was performed in an attempt to identify perinatal risk factors for the development of growth hormone deficiency. More of the affected children were boys, and their birth weights were significantly lower than those of the national average; there were also considerably more preterm and post-term deliveries among boys.

Adolescent↗
PubMed1986

When are we diagnosing growth hormone deficiency?

The height and age at presentation of 458 children beginning treatment with growth hormone between January 1980 and June 1984 were retrospectively analysed. Three hundred and nine children with isolated growth hormone deficiency had a mean (SD) age of 10 (4.1) years on beginning treatment and a mean (SD) height standard deviation score (SDS) of -3.73 (0.93). One hundred and nine patients with hypothalamopituitary tumours began treatment with growth hormone on average 3.3 years after diagnosis of the tumour and at a mean (SD) height SDS of -2.42 (1.49). In both of these categories the height SDS showed a considerable improvement compared with previous reports. Forty two patients with growth hormone deficiency secondary to cranial irradiation started treatment with growth hormone on average 6.1 years after treatment for their tumours and had a height SDS of -2.45 (1.02) compared with that of -2.45 (0.98) seen in nine similar patients from the United Kingdom starting treatment with growth hormone between 1975 and 1978. Although closer surveillance of short children in the community is leading to earlier diagnosis of growth hormone deficiency, this could possibly be diagnosed earlier if routine screening of height was to be carried out at school entry. In addition, patients who have received cranial irradiation should be regularly measured and investigated when their height velocity becomes subnormal.

Adolescent↗
PubMed1985

Growth of long term survivors of childhood malignancy.

The growth of all children from one referral centre alive and well more than three years following the diagnosis of malignancy was analysed. Those treated with chemotherapy alone showed significant catch up growth. Children treated with chemotherapy and spinal irradiation showed no overall height loss, but manifested significant reduction in sitting height. Those treated by cranial irradiation had a significant height loss in the first year from which no catch up growth occurred and also had significantly reduced sitting height.

Adolescent↗
PubMed1985

Final stature in brain tumours other than craniopharyngioma: effect of growth hormone.

The final growth pattern of 27 children who developed growth hormone deficiency after treatment of an intracranial tumour other than craniopharyngioma was assessed retrospectively. No patient achieved his or her genetic potential, though 12 attained an adult height above the the third centile for the population. All patients showed a tendency to a eunuchoid body build irrespective of whether puberty was spontaneous or not.

Adolescent↗
PubMed1984

Which deliveries require paediatricians in attendance?

The mode of delivery and one minute Apgar score were taken from the neonatal records of 2086 full term infants born at one obstetric unit over 12 months. There were 1554 spontaneous vaginal vertex deliveries, 26 vaginal breech deliveries, and 506 operative or instrumental deliveries. The obstetric records of the operative deliveries were reviewed to determine whether fetal distress had been an indication for intervention, and the obstetric records of the spontaneous vaginal vertex deliveries were also reviewed for fetal distress detected antenatally. When fetal distress was present antenatally in spontaneous vaginal vertex deliveries the frequency of a one minute Apgar score below 7 was 10.2%. In operative and instrumental deliveries where fetal distress was the indication for intervention the frequency of one a minute Apgar score below 7 was 15.6% after non-rotational forceps delivery, 13.9% after rotational forceps delivery, and 45.8% after caesarean section. In the absence of fetal distress the frequency of an Apgar score below 7 was 2.4% after spontaneous deliveries, 7.1% after non-rotational forceps delivery, 13.2% after caesarean section, and 18.4% after rotational forceps delivery. The presence of fetal distress considerably increased the frequency of an Apgar score below 7 in each category except rotational forceps deliveries. Paediatric services to an obstetric unit may be organised rationally in the light of local staffing conditions with the help of these findings.

Apgar Score↗
PubMed1984

Growth hormone deficiency presenting under age 2 years.

Twenty nine (1.8%) of a national cohort of 1600 patients with growth hormone deficiency presented before the age of 2 years. Sixteen of the 29 presented before 6 months of age--11 with symptomatic hypoglycaemia, four with failure to thrive, and one with obesity. Hypoglycaemia was persistent and difficult to control until growth hormone treatment was started. Ten of the 11 hypoglycaemic patients had multiple pituitary hormone deficiencies compared with two of the remaining five. Thirteen children presented between 6 months and 2 years of age; 12 had failure to thrive and one had spontaneous hypoglycaemia. Twelve of the 29 were boys and all but one of these had microgenitalia . Growth hormone deficiency should be considered in the differential diagnosis of infants presenting with refractory hypoglycaemia and in boys with failure to thrive and microgenitalia .

Age Factors↗
PubMed1983

The preterm infant: breast or bottle?

The long term survival of preterm infants has greatly improved in the last decade. Clinicians have consequently been able to concentrate more on their optimal nutrition and this has led to a controversy regarding the best milk for these infants. Current theory and practice suggests that the fastest growth and the best energy retention is obtained if a highly modified preterm formula milk is used. Banked mature human breast milk appears nutritionally inadequate and has no proven advantages. The use of fresh mothers' own milk merits further investigation, although its widespread use will usually be impractical.

Editorial↗
PubMed1983

Response to TRH in suspected hypopituitarism.

A retrospective analysis was made of 405 thyrotrophin-releasing hormone (TRH) stimulation tests on children who were successful applicants for growth hormone (GH) therapy in the UK between 1977 and 1981 inclusive. Thyroid-stimulating hormone (TSH) responses to TRH were divided into normal and those indicating pituitary or hypothalamic disease on the basis of criteria which eliminated variation in TSH assay between laboratories. Among children known to be hypothyroid 93% had abnormal TRH stimulation tests, but 35% of those children who were clinically euthyroid and who had normal serum thyroxin levels also had abnormal TSH responses to TRH. Abnormal TRH tests in the latter group were most common in euthyroid children who had GH deficiency with clearly defined aetiology and least common in those with idiopathic GH deficiency. Further work is required to clarify the interpretation of an abnormal TRH stimulation test in this group of children, but until this is done, such patients should be kept under regular review with respect to thyroid function.

Adolescent↗