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S M Kolesnikova

Publications and source records attributed to S M Kolesnikova.

15 recordsLinked to original sources
PubMed1991

[Indicators of erythro- and immunopoiesis in the development of autoimmune disease induced by graft vs host reaction].

Erythropoiesis and immunity are evaluated in (C57BL/6xDBA/2) F1 mice with immune complex glomerulonephritis induced by GVHR as compared to the genetically determined models of systemic lupus erythematosus. Elevated content of serum blood antinuclear antibodies, polyclonal activation during early disease periods, immune complex deposition in kidney tissues indicate the presence of the autoimmune syndrome in (C57BL/6xDBA/2)F1 mice, similar to that in mice with genetic lupus nephritis. The findings of a decrease of CFUs on days 5 and 8 at early times of disease, a reduction of hematocrit in combination with the enhancement of stem cell proliferation on the 6th-7th month of disease, an increase of the absolute leukocyte count and relative monocyte count in the peripheral blood of diseased mice may attest to the depression of stem cell differentiation in erythropoiesis and to the enhancement of stem cell differentiation in granulocyto-monocytopoiesis, that needs, however, further research and confirmation.

Animals↗
PubMed1982

[Age-related changes in the immune response of (CBA X C57BL)F1 hybrid mice. I. Stimulation of antibody formation in old animals].

A study of immune response to sheep erythrocytes in CBA X C57BL F1 hybrids of different age has shown a sharp fall in the number of antibody forming cells in the spleen of old mice. An analysis of data on stimulatory effect of preliminary sublethal irradiation and introduction of hydrocortisone upon antibody formation in old mice allows to conclude that cells-regulators inhibiting the antibody forming cells are accumulated in the spleen of old animals. These cells are sensitive to ionizing irradiation and hydrocortisone.

Aging↗
PubMed1982

[Absence of a stimulating effect of T-lymphocytes on the colony-forming activity of splenic hematopoietic stem cells].

Interaction of thymocytes with polypotent stem hemopoietic cells (PSHC) from the bone marrow and spleen was studied in the syngeneic system with the use of a model of an intermediate lethally irradiated recipient, in the spleen of which there is a contact between the test populations, as well as in the donor-recipient semi-allogeneic system. The PSHC of the bone marrow were found to differ in principle from those of the spleen. The difference concerned the regulatory importance of T-cells for stem hemopoietic elements. Thymocytes examined in both the systems stimulated proliferation of bone marrow PSHC but did not affect proliferation of spleen stem cells.

Animals↗
PubMed1978

[Effect of mouse age on the ability of hematopoietic stem cells to interact with thymus cells].

The effect of the thymus cells of the C57BL/6 mice on the colony forming ability of the stem hemopoietic cells of the embryonic liver and bone marrow of young (3 months) and old (2 years) mice was studied their joint transplantation into the mice (CBAXXC57BL/6) F1. The stimulating effect of the thymus cells on the colony forming ability of the stem hemopoietic cells of different age depends both on the dose of the stem hemopoietic cells of embryonic liver and the dose of T-lymphocytes. A suggestion is put forward that the stimulating effect of the thymus cells on the colony formation is due to their interaction with the stem cells in the G2 phase of the mitotic cycle.

Age Factors↗
PubMed1975

[Effect of thymocytes on the quantity of polypotent hematopoietic mast cells in the spleen of sublethally irradiated mice].

With the aid of Till and McCulloch's method, 5 times 10(-6) thymic cells were found to cause an increase in the number of hemopoietic endogenous spleen colonies in syngeneic donor-recipient combination. Thymic cells of C57BL mice had no effect on the number of endogenous colonies in the spleen. 40 times 10(-6) thymic cells administered 24 hr after sublethal irradiation caused an increase in the number of colony forming units in the spleen within 14 days. Possible ways of the thymus effect on hemopoiesis are discussed.

Animals↗
PubMedDate not supplied

[Age-related changes in the immune response of mouse (CBA x C57BL)F1 hybrids. II. Effect of hydrocortisone on the specific immunosuppression phenomenon and the role of nonspecific suppressor cells in the antibody formation process in old animals].

The effect of hydrocortisone on the phenomenon of specific immunosuppression and on antibody formation was studied in old mice. The decrease of immune response in the old CBA X C57BL F1 mice appears to be due to a high suppressive activity of cells-regulators which are accumulated in the spleen with senescence. It is suggested that these cells-suppressors belong to the population of non-specific T-cells sensitive to hydrocortisone. The effector T-cells-suppressors participating in specific suppression of the immune response to sheep erythrocytes in young CBA X C57BL F1 mice are resistant against hydrocortisone.

Aging↗