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S M Kotova

Publications and source records attributed to S M Kotova.

13 recordsLinked to original sources
PubMed2002

[Analysis of association of Col1a1 gene alleles with the development of osteoporosis].

Allele frequencies of the G-->T polymorphism at the regulatory region of the Collal gene in the population of the northwestern Russia (control group) and in osteoporotic patients were estimated by the RFLP method based on PCR-mediated site-directed mutagenesis. Three patient groups with radiologically confirmed osteoporosis were examined. Group 1 consisted of 64 patients with severe osteoporosis complicated by fractures (SO); group 2 included 15 children with idiopathic osteoporosis (IO); group 3 consisted of 98 women with postmenopausal osteoporosis developed at the background of estradiol-deficiency state (PMO). The frequency of functionally defective allele s in the control group was 16.7%. It was statistically different from that in the SO patients (48.4%) (P < 0.01) and in the IO children (40%) (P < 0.01). The frequency of allele s in the PMO patients constituted 23.0% and it was similar to that in the control group (P > 0.05). Analysis of the Collal alleles provides early detection of the individuals with hereditary predisposition to osteoporosis and prophylaxis of the disease at the presymptomatic stage.

Adolescent↗
PubMed1999

[The morphofunctional characteristics of the duodenum in an osteopenic syndrome in children and adolescents].

AIM: The study of duodenal morphology in children and adolescents with skeletal deformity. MATERIALS AND METHODS: Clinical, hormonal examinations, x-ray investigation of the skeleton with spinal NMR-tomography, gastroduodenoscopy with target biopsy were performed in 41 patients aged 7 to 18 on after treatment for broken spine. RESULTS: Atrophic duodenitis found in most of the patients presented without dyspepsia, with symptoms of duodenitis in 8 patients, osteoporosis in 36% of patients. NMR-tomography rejected compression-broken spine in 22 patients. CONCLUSION: Disturbed absorption of calcium and atrophic alterations in the duodenal mucosa are thought responsible for disturbance of calcium metabolism and formation of bone tissue.

Adolescent↗
PubMed1989

[Osteopathy in malabsorption syndromes].

Electrolytic imbalance is a frequent finding in malabsorption syndrome. Derangement of calcium metabolism present clinically in different variants is most serious. Some patients develop hypocalcemia manifesting clinically with specific myasthenia, paresthesias, convulsions, hemorrhages, etc. In other variants severe skeletal lesions are seen which may become dominating in the clinical picture though hypocalcemia was absent. Investigation of calcium metabolism, hormonal profile (parathormone, in particular) in malabsorption syndrome can prognosticate and prevent the onset of osteomalacia.

Adolescent↗
PubMed1984

[Use of extracorporeal hemosorption for the preoperative preparation of toxic goiter patients].

The method of extracorporal hemosorption was used by the authors first in the clinical practice for the preoperative preparation of patients with thyrotoxicosis. Oxygenated SKN carbons were used as sorbents. The hemosorption was used in 16 patients with thyrotoxic goiter by the method developed in the clinic. The authors make a conclusion that hemosorption is an expedient method for the preoperative preparation of patients with a toxic goiter.

Female↗
PubMedDate not supplied

[Radiation diagnosis of involutional osteopenia].

160 patients with involutive osteopaenia were investigated. The diagnostic possibilities of roentgenography, magnetic resonance imaging and computed tomography were evaluated. There was determined that roentgenography gives the possibility to determine the common localisation and the expressiveness of the pathologic process. MRI and CT give a valuable additional information on early stages of osteopaenia and it's complications.

Adult↗