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Biomedical subjects

S M Loriaux

Publications and source records attributed to S M Loriaux.

6 recordsLinked to original sources
PubMed1989

Prophylaxis in gynaecological surgery: a prospective randomized comparison between single dose prophylaxis with amoxycillin/clavulanate and the combination of cefuroxime and metronidazole.

A prospective randomized comparison of a single pre-operative dose of 2.2 g amoxycillin/clavulanate versus the combination of 1.5 g cefuroxime plus 0.5 g metronidazole was conducted in 467 women, who underwent gynaecological surgery. The incidence of febrile morbidity, urinary tract infection, wound infection and the use of post-operative antimicrobial agents was similar in the two groups. Amoxycillin/clavulanate is as effective as a combination of cefuroxime and metronidazole and less expensive.

Adult↗
PubMed1988

Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.

A prospective randomized study was conducted comparing a single 2.2 g preoperative dose amoxycillin/clavulanic acid with a regimen of 1.5 g cefuroxim combined with 0.5 g metronidazole. Two hundred and fifty-one women were evaluated in this comparative study. The febrile morbidity, the incidence of urinary tract infections and the hospital stay were similar in both regimens. A single preoperative dose of amoxycillin/clavulanic acid was as effective as a combined regimen of cefuroxim and metronidazole and less expensive.

Adult↗
PubMed1987

Amoxycillin, amoxycillin-clavulanic acid and metronidazole in the treatment of clue cell-positive discharge. A comparative clinical and laboratory study.

In an open study, 30 women with clue cell-positive discharge (CCPD) were treated for seven days with either amoxycillin, amoxycillin-clavulanic acid or metronidazole (ten in each group). Patients were monitored on days 2, 4, 9 and 15. Clinical and microscopical parameters were used to assess treatment efficacy. Gas-liquid chromatography of vaginal secretions was also performed. The succinate-lactate ratio had good correlation with the clinical findings. All patients treated with metronidazole were cured by day 4, suggesting that a three-day course is as effective as the standard seven-day regimen. Treatment with amoxycillin-clavulanic acid was less effective resulting in the cure of seven patients by day 15. Amoxycillin established normal secretions in only four patients. Gastro-intestinal complaints, although common in patients treated with amoxycillin-clavulanic acid, were generally mild. We consider amoxycillin-clavulanic acid a possible alternative in the treatment of CCPD.

Adult↗
PubMed1986

Task effects and individual differences in the study of lateral eye movements.

Twenty-nine males and 29 females (all right-handed) participated in this study. The effects of question type (numerical, verbal, spatial) and experimenter position (in front of or behind the subject) on direction of lateral eye movements (LEMs) were tested. Also the relation between dominant LEM direction and other individual traits was investigated. The percentage of LEMs (tonic changes) as well as the first LEM (phasic changes) in the reflective period was scored. Results were identical for both methods; there were no task-specific effects demonstrated, nor was a relation found between dominant LEM direction and imagery, extraversion, neuroticism, sensation seeking, impulsiveness, and amount of somatic and psychic complaints. It appeared that the extent to which subjects gazed away varied with the amount of stress that was induced, while the direction of glance depended on the individual habit of the subject. The conclusion was that LEMs are subject specific rather than task specific and that this individual specificity is strengthened under stress conditions.

Cerebral Cortex↗
PubMed1985

The effects of nicotinic acid and xanthinol nicotinate on human memory in different categories of age. A double blind study.

The treatment effect of nicotinic acid and xanthinol nicotinate on human memory was compared with placebo in 96 healthy subjects. Forty-three subjects were young (35-45 years), 30 subjects middle aged (55-65 years) and 23 subjects were old aged (75-85 years). Pre- and post-treatment scores were measured on a battery of memory tasks, covering sensory register, short-term memory and long-term memory. The treatment regime was 1 dragee t.i.d. for 8 weeks. The administration of xanthinol nicotinate (500 mg, containing 141.7 mg nicotinic acid), nicotinic acid (141.7 mg) and placebo (lactose) was double-blind. Pre- and post-treatment scores were analysed by means of a multivariate covariance technique, the pre-treatment score serving as covariate. Nicotinic acid treatment resulted in improvement of sensory register and short-term memory, while xanthinol nicotinate improved sensory register, short-term memory and long-term memory. In comparison with placebo, both active compounds yielded improvements of 10-40%, depending on type of task. Treatment effects of nicotinic acid were predominantly found in the young and middle-aged, whereas treatment effects of xanthinol nicotinate were predominantly found in the old. These results are interpreted by the supposed activity of nicotinic acid at the cell membrane, improving neuronal transmission, and of xanthinol nicotinate inside the cell, enhancing cell metabolism and oxygen supply in the brain.

Adult↗