PubMed Health⌕ Search

Biomedical subjects

S M Makeev

Publications and source records attributed to S M Makeev.

8 recordsLinked to original sources

[Immunologic monitoring of leptospirosis in the Maritime Territory].

The epidemiological and epizootic situation in Leptospira infections at the Maritime [correction of Primorski] Territory is evaluated on the basis of complex studies carried out in 1984-1989. As revealed in these studies, cases of leptospirosis among humans have a sporadic character and are mainly registered among professional high risk groups of the population. In the immunological structure of persons covered by the survey L. hebdomadis, L. pomona and L. javanica prevail. The anthropourgic foci of leptospirosis caused by L. pomona are of the leading epidemiological importance. Swine serves as the main source of infection in these foci. The study revealed the epidemic danger of the natural foci of leptospirosis caused by L. grippotyphosa and L. javanica in rice fields where the decisive factors of leptospirosis proved to be reed voles and striped field mice serving as reservoirs of this infection, as well as the synanthropic foci of leptospirosis caused by L. hebdomadis with house mice serving as the main carriers.

Animals↗

[Osteocalcin in infants with rickets].

Infants afflicted with rickets demonstrate a reduction in the blood content of vitamin K-dependent protein, osteocalcin, most pronounced in disease of medium gravity, in its calcipenic and phosphopenic varieties. It has been established that there is an inverse correlation between osteocalcin content and the level of parathyroid hormone and a direct correlation between osteocalcin content and the concentration of total and ionized calcium and calcitonin in the blood. It is suggested that measurement of blood osteocalcin in children may serve a diagnostic marker of metabolic disorders and mineralization of osseous tissue.

Calcium↗

[Epidemiological aspects of leptospirosis in the eastern regions of the Russian Federation].

There have recently substantial changes in the basic parameters of Leptospira infection in the eastern regions. The infection is characterized by a pronounced and steady-state rise in morbidity rates, by its trend for urbanization, by the spread of the disease in recreational areas, by a primary role of dogs as sources of infection, by polymorphism and atypical nature of the clinical picture of Canicola leptospirosis, which make its diagnosis difficult. The anthropurgic foci where dogs and pigs are the main sources of pathogenic leptospiras are of the leading epidemiological significance. The optimum package of measures reducing a risk of human infection is recommended.

Adolescent↗

[The epidemiological and epizootiological characteristics of leptospirosis in the Republic of Sakha (Yakutia)].

Among zoonotic infections with natural foci in the Republic of Sakha (Yakutia), leptospiroses have assumed greater importance. Their morbidity is sporadic, mainly afflicting rural adults. The serogroups pomona, grippotyphosa, and icterohaemorrhagiae are prevalent in the etiological structure of leptospiras. An epizootiological survey has revealed natural and anthropurgic leptospirosis foci which present a hazard primarily to rural inhabitants who deal with animal husbandry, fur-bearer breeding, hunting, and fishing. The vole (Microtis) and root vole (Microtis oeconomus) serve as the major reservoir and source of leptospiroses in the natural foci, while cattle and caged Arctic foxes do in the anthropurgic ones. High sizes of house and grey mice which are carriers of the Leptospira javanica and icterohaemorrhagiae, have been recorded in the residential and domestic constructions of localities. A complex of antileprospirotic measures that limits the influence of the leading factors of infection transmission and the risk of human infection is substantiated.

Adult↗

[Zoonotic infections in the central and southern ulusy of the Republic of Sakha].

The serological survey of humans, as well as agricultural animals and rodents, for the presence of zoonotic infections, was carried out. Local inhabitants were shown to have contacts with the causative agents of pseudotuberculosis, enteric yersiniosis, tularemia, leptospirosis, Q fever, tick-borne rickettsiosis, chlamydiosis, toxoplasmosis. The immune stratum with respect to enteric yersiniosis was found to have a greater index, while the immune strata with respect to chlamydiosis, Q fever, pseudotuberculosis had the least indices. However, the indices of immune strata perceptibly varied in individual regions. The highest occurrence of antibodies to all above-mentioned zoonotic infections was registered in Megino-Kangalasskiĭ, Amga and Neriungrinskiĭ ulusy [correction of regions]. The probable sources of leptospirosis, toxoplasmosis and Q fever were agricultural animals, while the probable sources of enteric yersiniosis and leptospirosis were rodents.

Animals↗