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Biomedical subjects

S M Markin

Publications and source records attributed to S M Markin.

4 recordsLinked to original sources

[The diagnosis and treatment of chromaffinomas].

The results of examinations and surgical treatment of 117 patients with chromaffin tumors are shown: one-sided localization in the adrenal in 88% of the patients, bilateral localization in 4.3%, and extraadrenal in 7.7%. An analysis of the possibilities of the laboratory-instrumental diagnosis of chromaffinomas has shown that the method should be used in case of valid need. The absence of changes to the level of catecholamines and their metabolites in urine does not exclude the presence of chromaffinomas. The optimal access for the ablation of chromaffinoma of the adrenal larger than 5 cm in diameter is thoracofrenotomy in the tenth intercostal space. Endovideosurgical interventions in the adrenals can be used for the size of chromaffinoma less than 5 cm in diameter and with the absence of signs of malignisation and marked hemodynamic disorders. The superior medial laparotomy is expedient for extraadrenal pheochromocytoma of the abdominal area and for bilateral localization in the adrenals.

Adrenal Gland Neoplasms↗

["Silent" pheochromocytomas].

The results of surgical treatment of 126 patients with "hormonally inactive" and catecholamine secreting tumors of the adrenals were studied. Among them 2 cases (1.6%) of "dumb" pheochromocytoma were diagnosed. The clinical observations have shown the difficulties in the diagnosis of "dumb" pheochromocytoma before operation, risk of performing adrenalectomy and necessity to correct hemodynamic disorders during anesthesia in connection with latent catecholamine activity. The laboratory and instrumental means of examination of patients with suspected "hormonally inactive" tumor of the medullary substance of the adrenal are proposed. The variants of prevention and arrest of hemodynamic disorders during ablation of the "dumb" pheochromocytoma were considered. When the "dumb" pheochromocytoma had the diameter less than 5 cm and the adequate preparation was conducted the authors propose a laparoscopic access for adrenalectomy on the right, and retroperitoneoscopic access on the left. The detection of the catecholamine secreting tumor of more than 5 cm diameter, when problems with the clipping of the central vein of the adrenal take place, open accesses should be preferred--mainly thoracophrenotomy in the X intercostal space. If it was not possible to prove "dumb" pheochromocytoma before operation and it was started with endovideosurgical intervention during which it was not possible to first clip the central vein of the adrenal and the risk of hemodynamic disorders was high, the early transition to open operative intervention is thought to be expedient.

Adrenal Gland Neoplasms↗

[Early cessation of artificial ventilation of the lungs (extubation of the trachea in the operating room) in patients undergoing surgery with artificial circulation].

Forty-nine patients operated on the open heart under combined total anesthesia with nitrogen oxide, enflurane or isoflurane and propofol (group 1) and 22 ones anesthesized with high fentanyl doses (group 2) were examined. To group 1 patients fentanyl and pancuronium bromide were injected only in the preperfusion period of the operation. Early extubation was carried out in 44 (90%) group 1 patients. The duration of postoperative artificial ventilation of the lungs was 102 +/- 15 min in group 1 and 16 +/- 1 h in group 2. No grave postoperative complications or early mortality were recorded. In the morning of the first postoperative 24 h 7% of group 1 patients and 41% of group 2 ones were administered inotropic therapy (p < 0.05). Duration of stay in resuscitation ward was 0.96 +/- 0.05 days in group 1 and 2.04 +/- 0.09 days in group 2 (p < 0.01). The authors come to a conclusion on the desirability of early extubation after open-heart surgery. Indications for and contraindications against early extubation are discussed.

Adult↗