PubMed Health⌕ Search

Biomedical subjects

S M Parshikova

Publications and source records attributed to S M Parshikova.

32 records · Page 2Linked to original sources
PubMed1981

[Metastatic melanoma of the brain].

Clinical and clinico-pathoanatomical comparisons (60 observations) have shown that in patients with primary cutaneous melanoma and its metastases treated by modern methods the tumour metastasis to the brain occurs in late periods of the disease at the stage of the neoplastic process generalization. Histological examinations of the melanoma metastases of various localization revealed a much lesser differentiation of the tumour cells and a greater vascularization of the tumour. The pronounced vascularization is characteristic for metastases of any localization, both visceral and cerebral, at the stage of the process generalization.

Adolescent↗
PubMed1980

[Ovarian struma].

The paper presents a histological and electron microscopic description of the ovarian struma having the structure of thyroid tissue and consisting predominantly of A cells with the ultrastructural features typical of this cell species.

Female↗
PubMedDate not supplied

[Sex steroid hormone receptors in the cytosolic fraction of cancer and leukoplakia of the oral mucosa].

The paper deals with the studies of sexual steroidal hormone receptors in the tumor cytosolic fraction in 37 patients with squamous cell carcinoma and in 18 patients from leukoplakia foci in the oral mucosa. One or two types of androgen and estrogen receptors were detected in the tumor cytosolic fraction in most female (75%) and male (62%) patients with squamous cell carcinoma. The detection rate and the mean values of androgen and estrogen receptors in squamous cell carcinoma of the oral mucosa were associated with sex, age, disease stage, type of growth and site of a tumor. Detection and levels of androgen and estrogen receptors in the leukoplakia foci of the oral mucosa depended on the age of patients. Cytoplasmic estrogen receptors (50%) and oral mucosal squamous cell cancer (34.4%) were much more encountered in the foci of leukoplakia and their mean levels tended to increase. The mechanism of action of sexual steroids on normal and tumor target cells, the role of androgens and estrogens in the pathogenesis of oral mucosal carcinoma and leukoplakia, and possible methods of endocrine therapy for these diseases are discussed.

Aging↗
PubMedDate not supplied

[Metal-dependent collagenolytic activity in primary foci and metastatically involved lymph node in melanoma].

Collagenolytic activity was estimated in primary focuses of melanoma, in preparations of normal skin surrounding the tumor, in benign pigmentary neoplasms (nevus) as well as in normal and metastatic lymph nodes. Both metal-dependent and -independent collagenolytic activity was significantly increased in tumoral tissues as compared with that of healthy tissues. At the same time, the collagenolytic activity was considerably lower in benign pigmentary neoplasms than that of melanoma primary focuses. Importance of the collagenolytic enzymes in the processes of melanoma invasion and metastatic spreading is discussed.

Adult↗