Biomedical subjects

S M Radaev

Publications and source records attributed to S M Radaev.

3 recordsLinked to original sources

PubMedDate not supplied

[Effect of perftoran on morphology and rheologic properties of erythrocytes in patients with severe trauma and blood loss].

Erythrocyte morphology and function, plasma viscosity, central hemodynamics and oxygen status were studied in patients with severe injury and blood loss. The percentage of morphologically changed erythrocytes (mainly stomatocytes) increased, their filterability changed negligibly. Changes in these parameters were studied during intravenous infusion of perfluorane. Perfluorane therapy during the acute period of severe injury decreased total peripheral and pulmonary vascular resistance and reduced the entry of an extra amount of structurally changed erythrocytes from peripheral tissues into the blood stream.

Erythrocytes↗

PubMedDate not supplied

[Acute hemorrhage. View on the problem].

Acute hemorrhage is a main cause of reduction of blood oxygen capacity. The main aim of correction of sequels of acute hemorrhage is to maintain effective gas exchange by restoring central circulation and microcirculation, the rate of diuresis, by normalizing water-salt exchange, to eliminate anemia, hypoproteinemia, and acute blood coagulability disorders. The values of oxygen budget with calculated oxygen delivery and consumption and those of hemoglobin and hematocrit which are of great value only after recovery of circulating blood volume are considered to be major indications for hemotransfusion. A relationship is established between the extraction and uptake of oxygen and its delivery. The concept of the critical level of oxygen delivery is considered, ways of correcting oxygen indebtedness are presented. Alternatives to the use of hemotransfusions by employing the solutions of modified hemoglobulin and perfluorocarbon-containing emulsions are under consideration. A possible algorithm of aid rendering in acute hemorrhage is given.

Acute Disease↗

PubMedDate not supplied

[Effect of perftoran on the oxidant-antioxidant system in patients with severe trauma and blood loss].

Diminution of reperfusion and re-oxygenation lesions is an important task in the treatment of patients with severe injury and blood loss. From this standpoint the influence of perforan on the condition of the oxidant-antioxidant system was studied in patients with severe combined trauma. The application of perftoran in the early post-trauma period was found to intensify the processes of lipid peroxidation and, simultaneously, to normalize the parameters of the antioxidant-protection system.

APACHE↗