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Biomedical subjects

S M Rose

Publications and source records attributed to S M Rose.

7 recordsLinked to original sources
PubMed1991

Acknowledging abuse backgrounds of intensive case management clients.

Routine inquiry about abuse experiences as children and adults yielded high levels of positive responses among 89 intensive case management clients. Through structured interviews administered by their case managers, clients disclosed backgrounds in families with one or more alcoholic adults, incest, other childhood sexual abuse, and extensive physical abuse. Gender played a major role. Being an ACOA also predicted extensive additional abuse. Clients were not treated for abuse, nor diagnosed for its impact, nor responded to when they initiated discussion with mental health providers. Later outcomes include frequent hospitalizations, substance abuse and self-mutilation.

Adult↗
PubMed1991

Undetected abuse among intensive case management clients.

A study of the first 89 clients referred to an intensive case management program revealed substantial previously undetected physical and sexual abuse, yet none of the clients had ever been asked about their abuse experiences. Fifty percent of the clients were adult children of alcoholics, and 34 percent were childhood sexual abuse victims. The adult children of alcoholics experienced significantly more of every kind of abuse, including incest and childhood physical and sexual abuse, than clients whose parents were not alcoholic. Substance abuse problems were reported by more than half of the clients and by 75 percent of the adult children of alcoholics. Self-mutilation and heavy use of mental health services were also correlated with having an alcoholic parent. The authors suggest that mental health providers make routine inquiry about clients' family history of alcoholism and history of physical and sexual abuse.

Adult↗
PubMed1991

Responding to hidden abuse: a role for social work in reforming mental health systems.

Clients in a state-funded intensive case management program, most of whom were identified as heavy users of acute care and psychiatric emergency rooms, had undetected brutal life experiences: 50 percent were adult children of alcoholics, and many were sexually and physically abused as children or adults. None had been asked about or appropriately treated for these aspects of their background. Statistical analysis indicated high levels of correlation between exposure to alcohol abuse in the family, physical or sexual abuse, repeated hospitalization, and contemporary suffering. Social work can use this and related data to make mental health systems more responsive to clients' needs at both the clinical and systems levels.

Adult↗
PubMed1979

The carboxy-terminal peptides of in vitro precursor and in vivo mature kappa light chains are identical.

Protein structural analysis of several precursor light chains indicates that these in vitro products include a cysteine-containing tryptic peptide that is indistinguishable from the carboxy-terminal tryptic tripeptide present in in vivo mature kappa light chains. It is concluded that although in vitro precursor light chains contain an additional amino-terminal sequence, their carboxy-terminus is the same as that found in in vivo mature light chains.

Amino Acid Sequence↗
PubMed1979

Deciphering deinstitutionalization: complexities in policy and program analysis.

Deinstitutionalization as a public policy promised to be a major departure from previous psychiatric practice. Decrying traditional "medical paradigms" and the custodial "warehousing" of mental patients, policy makers advanced a "bold new approach" for care in the community. Progressive humanitarian reform could go hand in hand with fiscal conservatism. Community Mental Health Centers were to be the heart of a new national effort. But the rhetoric of reform failed to coalesce the activities among competing federal and state interests and systems. Intended beneficiaries may have become unfortunate victims.

Community Mental Health Services↗
PubMed1977

Cloned MPC 11 myeloma cells express two kappa genes: a gene for a complete light chain and a gene for a constant region polypeptide.

Cloned MPC 11 mouse plasmacytoma cells synthesize a complete kappa light chain and also a kappa light chain constant region fragment. Partial amino terminal sequences of the in vitro forms of these two proteins have been determined. Both in vitro products contain typical light chain leaders; leaders are defined as the amino terminal sequences present on in vitro products but absent from the in vivo products found in living cells. The in vitro form of the MPC 11 complete light chain contains a leader sequence plus variable and constant region sequences. The in vitro form of the MPC 11 light chain constant region fragment contains a different leader sequence attached directly to a complete constant ragion sequence and has no variable region sequences. Thus the MPC 11 light chain fragment is not a degradation product of the MPC 11 complete light chain (or of any other complete light chain) and must be coded by a separate gene. The results reveal two unusual features of MPC 11 cells: first, expression of a unique variant light chain gene coding the light chain constant region fragment, and second, expression of two different kappa light chain genes (coding the complete light chain and the variant constant region fragment) in a single cell. In addition, evidence is provided that the in vitro forms of kappa light chains, three of which are presented here for the first time, include a minimum of three partially homologous but quite different leader sequences.

Amino Acid Sequence↗