Biomedical subjects

S M Sampson

Publications and source records attributed to S M Sampson.

3 recordsLinked to original sources

PubMed2001

Depression in adolescence.

Major depression is a common mental health disorder in adolescents that predicts a significant risk for recurrence in adulthood. Suicide is the third most frequent cause of deaths in this age group, and depression is a significant risk factor for suicidal ideation and attempts. Risks for depression and suicidal ideation are reviewed, and subtypes of depression are discussed. Difficulties associated with identification of depression and suicidal ideation in adolescents and biologic therapies for adolescent depression are reviewed.

Adolescent↗

PubMed2001

Treating depression with selective serotonin reuptake inhibitors: a practical approach.

Depression is a common disorder that is becoming better understood as an illness that can be chronic, recurrent, and refractory to treatment. Depression can produce substantial suffering and profoundly affect a patient's self-esteem, relationships, and functional capacity. The improved adverse-effect profile and safety from overdose of selective serotonin reuptake inhibitors (SSRIs) have led to treatment of milder forms of depression and thus increased treatment of depression overall. This article synthesizes several previously published reviews and psychopharmacology resources and addresses practical issues related to initiating, monitoring, continuing, and discontinuing SSRIs. Precautions related to SSRI use and important considerations for various types of depression are discussed.

Chronic Disease↗

PubMed1988

Sensory deafferentation fails to modify muscarinic receptor binding in raccoon somatosensory cortex.

The characteristics and distribution of muscarinic acetylcholine (mACh) receptor binding in primary somatosensory (SI) cortex and the caudate nucleus of raccoons were studied using [3H]-QNB, a muscarinic antagonist. The binding characteristics were similar to reported values in rat and cat. Autoradiographs produced from tissue sections labeled with [3H]-QNB showed the distribution of mACh receptors in the forebrain of the raccoon. [3H]-QNB binding was highest in cerebral cortex, neostriatum and hippocampus. Within SI cortex, binding was high in layers I-III and VI and relatively low in layers IV and V. Autoradiographs obtained from animals that had undergone peripheral deafferentation of part of the forepaw revealed no changes in [3H]-QNB binding in the affected cortical region during the time that physiological reorganization is known to occur.

Afferent Pathways↗