Biomedical subjects
Publications and source records attributed to S M Selikowitz.
Vesicoureteral reflux during formalin therapy of intractable hemorrhagic cystitis can be prevented with Fogarty catheters inserted cystoscopically into the lower ureters. With this technique formalin instillation and cystography can be done through the cystoscope at the same time. Topical intravesical vasopressin did not, in our experience, lessen the bladder hemorrhage.
Utilizing a low pyridoxine, ethylene glycol-fed rat model, various modes of anticalculus therapy were compared. Prophylactic papillary and parenchymal oxalate stone therapy is most effective with magnesium oxide. Hydrochlorothiazide is next in order as the therapy of choice in this group. A high calcium diet seems to negate the effect of magnesium oxide. Methylene blue, magnesium oxide, and even sodium phosphate, are not as effective as hydrochlorothiazide in the combined prevention and treatment of preformed parencymal calcium oxalate stones. No agent seems to have a profound effect on preformed apical papillary calculi.
Inadvertent use of tetracycline hydrochloride while producing calcium oxalate stones in the rat resulted in a reduction of papillary concretions by one-half. Parenchymal calcifications in the continuing long term, preformed stone group were reduced to levels comparable to that of other useful agents. In vitro studies corroborated these findings at physiologic urinary pH ranges. The rationale and comparisons to other anticalculus drugs are discussed.
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A variable waveform electrosurgical unit (VWESU) was designed and used for electrosurgical research. The design criteria included the ability to modulate the amplitude of a sinusoidal carrier on a cycle-by-cycle basis, output power equivalent to commercial generators, and provision for varying the output impedance. These were realized with a microprocessor-controlled variable waveform generator which allows the user to program waveforms into memory with a set of simple descriptive commands, a linear power amplifier, and a custom output transformer. The contents of the memory are directly pipelined to a set of analog switches, which modulate the radio-frequency carrier with one of eight amplitude levels, thereby bypassing the speed limitations of the microprocessor.