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Biomedical subjects

S M Small

Publications and source records attributed to S M Small.

17 recordsLinked to original sources
PubMed1989

Tumoricidal effect of interleukin-2-activated killer cells in canines.

We investigated the effect of both partially purified (TCGF) and recombinant interleukin-2 (rIL-2) on the tumor-directed cytotoxic activity of canine peripheral blood mononuclear cells (PBMC) using three normal canines. No cytotoxic activity was displayed by unstimulated effector cells at 3 h of incubation; however, the cytotoxic effect was observed in a 16-h assay. PBMC of all canines displayed significant levels of lytic activity after stimulation for 4 to 7 days with both types of IL-2 against a variety of allogeneic and xenogeneic neoplastic cells in 3-h 51Cr release assay. The cytotoxic activity of cultured cells increased proportionally in the 16-h assays. Morphological examination of the May-Grünwald and Giemsa stained cytocentrifuged slides of cultured cells on each day of assay showed an increase in large granular lymphocytes (LGLs) beginning on day 4 and reaching a peak on day 7 of culture.

Animals↗
PubMed1989

Response of parotid gland organ culture to radiation.

Organ cultures of rhesus parotid tissue in medium enriched with homologous serum and supplemented with low levels of isoproterenol were irradiated with single photon doses of 2.5, 5.0, 7.5, 10.0, 12.5, or 15.0 Gy. Following irradiation, the tissue was incubated while being agitated for 24 h; then it was fixed in formalin. Microscopically, death of serous acinar cells was seen in areas unaltered by autolysis. Based on the numbers of nuclear aberrations, the dose response did not differ significantly from that observed at 24 h in parotid gland irradiated in vivo. The similar rapid response under the two conditions shows that apoptosis of irradiated parotid serous cells is a direct expression of interphase cell death.

Animals↗
PubMed1975

Limitations and values of evaluation techniques in psychiatric education.

The author presents a summary of the major evaluation techniques now available and discusses the values and limitations of each. He concludes that only by the use of many evaluation instruments during the resident's period of training can some estimate of clinical competence be approached. Even with this multiplicity of testing instruments, the validity of predictions of a psychiatrist's performance can be determined only in terms of probabilities.

Clinical Competence↗
PubMed1975

Recertification of psychiatrists: the time to act is now.

Because of the predictions of partial obsolescence for psychiatry as a profession and because of the increasing pressures of government, third-party payers, and a patient population that will no longer blindly follow physicians, psychiatrists must face the demands for professional accountability. The author suggests that to maintain high-quality care and continuing self-governance, psychiatrists must participate actively in self-assessment and continuing education programs.

Certification↗