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Biomedical subjects

S M Standish

Publications and source records attributed to S M Standish.

18 recordsLinked to original sources

Investigation of the 1987 Indianapolis Airport Ramada Inn incident.

On October 20, 1987, a military reserve aircraft lost power during a transcontinental flight and attempted an emergency landing at The Indianapolis International Airport. The pilot ejected and the disabled and pilotless aircraft struck a bank building. It then skidded across the street and entered the lobby of The Airport Ramada Inn where it exploded. This incident was unusual in that the fatal injuries occurred in individuals on the ground and not in the occupant of the aircraft. Seven people were killed in the lobby area and two were trapped in a laundry where they died of smoke inhalation. A tenth person died of burns ten days later. Minor injuries were reported among four hotel guests, two firefighters and the Air Force pilot. A multiagency mass disaster-plan had been formulated and rehearsed in preparation for the Panamerican Games, which had been held in Indianapolis in August 1987. A number of volunteers arrived before a security perimeter was established. They began an undocumented removal of the bodies from the scene and were about to remove valuables for "safekeeping" when stopped by coroners' office personnel. Fatalities resulted from smoke inhalation, burns or a combination. Bodies were identified by a combination of dental records, personal effects and visual means within 24 hours. The problems encountered in managing this disaster scene will also be compared with previously reported incidents.

Accidents, Aviation↗

Specimens for teaching forensic pathology, odontology, and anthropology. I. Soft tissue.

A set of specimens has been collected, preserved, and organized specifically for the teaching of forensic pathology, odontology, and anthropology. Plastination of soft tissue, whole organs, bones, and teeth has proven valuable in preserving delicate, friable, and calcined specimens. The dry, odorless, biologically inert specimens are durable and resistant to damage caused by handling. Subtle features of soft tissue pathology are well preserved. Patterned injuries change due to shrinkage, but remain easily recognizable. Plastinated whole jaws are still readily identifiable from antemortem records. Radiographic density is essentially unchanged. Putrid and charred specimens become quite manageable.

Anthropology, Physical↗

Specimens for teaching forensic pathology, odontology, and anthropology. II. Teeth and bone.

A set of specimens has been collected, preserved, and organized specifically for the teaching of forensic pathology, odontology, and anthropology. Plastination of soft tissue, whole organs, bones, and teeth has proven valuable in preserving delicate, friable, and calcined specimens. The dry, odorless, biologically inert specimens are durable and resistant to damage caused by handling. Subtle features of soft tissue pathology are well preserved. Patterned injuries change due to shrinkage, but remain easily recognizable. Plastinated whole jaws are still readily identifiable from antemortem records. Radiograph density is essentially unchanged. Putrid and charred specimens become quite manageable.

Anthropology↗

Dopamine D-1 and D-2 receptor antagonists potentiate analgesic and motor effects of morphine.

To examine the role of dopamine receptor subtypes mediating analgesic and motor responses to opioids, rats were pretreated with either saline or a selective D-1 or D-2 dopamine receptor antagonist 10 min prior to morphine (12 mg/kg IP). Analgesic response latency was determined using the hot plate test (52.5 degrees C and 55 degrees C), and catalepsy was assessed using the abnormal posture test. Morphine increased analgesic response latency to 44.5 +/- 7.9% of the maximum possible response, but had no cataleptic effect in the abnormal posture test. Pretreatment with either the D-1 antagonist, SCH 23390 (50-100 micrograms/kg), or the D-2 antagonist, eticlopride (20-150 micrograms/kg), potently enhanced morphine analgesia as measured on the 52.5 degrees C hot plate. Peak analgesic responses to morphine increased to 100 +/- 0% and 91.9 +/- 7.5% of maximum with the highest doses of SCH 23390 and eticlopride, respectively. These treatments also produced catalepsy. Increasing the hot plate temperature to 55 degrees C reduced response latency in groups treated with either dopamine receptor antagonist plus morphine. This indicates that the animals were capable of responding at a shorter latency and demonstrates that motor impairment cannot account for potentiation of morphine analgesia by D-1 and D-2 antagonists at 52.5 degrees C. These results show that the relationship between dopamine and opioids with respect to analgesic and motor systems involves both dopamine receptor subtypes.

Analgesics↗

Osteoarthritis of the TMJ in teenaged females: report of cases.

From the cases reported by Ogus and those presented here, it appears degenerative joint disease of the TMJ in young individuals is not a rare finding. The incidence of DJD of the temporomandibular joint has been reported to be 8% to 16%. In a review of 346 patients who were referred for jaw disorders, 23 patients were 19 years old or younger. Six patients (or 26%) had a diagnosis of osteoarthritis of the TMJ confirmed with charts, reviewed retrospectively, were considered as suggestive of degenerative joint disease. It has been reported that the symptoms of DJD continue for one to three years. The majority of patients have acute symptoms that usually last about nine months but gradually subside after nine months. It is important to rule out degenerative disease of the TMJ before beginning radical or irreversible dental procedures. Conservative management of these patients includes analgesics, antiarthritic drugs, muscle relaxants, antiinflammatory agents, the construction of hard or soft bite splints, exercise, warm moist heat applications, minor equilibration if indicated, and physical therapy. Injections of steroids into the joint are not recommended and anti-arthritic drugs should be used with caution because the safe usage of some of these drugs has not been demonstrated in children. Patients who still experience pain after one to three years, or patients who are refractory to conservative therapy, may be candidates for surgical treatment. Age should not be a deterrent to surgery or other treatment modality for treatment of severe degenerative joint disease that does not respond to conservative treatment and is intolerable to the patient.

Adolescent↗

Blood group determinations in forensic dentistry.

The identification of A, B, and H substances is a useful tool in forensic examinations. At the present time fresh blood or blood stains are used most extensively for blood group detection in forensic cases. Various body fluids from secretors also contain A, B, and H substances, and recent techniques have increased the reliability of the determination of blood group substances present. Soft and hard tissues also contain blood group substances, but at the present time these are not used routinely in forensic examinations. However, adaption of the more sensitive assays may increase the utilization of these tissues. Of particular value would be the development of simpler methods for blood group substances in teeth, since teeth are more resistant to putrefication than most other substances.

ABO Blood-Group System↗