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Biomedical subjects

S M Tkach

Publications and source records attributed to S M Tkach.

16 recordsLinked to original sources
PubMed1999

[Helicobacter pylori prevalence among patients with gastroduodenal diseases in Kiev].

It is for the first time in Ukraine that a study has been made on the epidemiology of H. pylori infection among patients with disorders of the stomach and duodenum. The diagnosis of the infection was done with the aid of various invasive and noninvasive tests, 13C-urea breathing test, a unique for Ukraine and countries of the Western Europe method of examination included. Ascertained among the above category of patients was wide prevalence of H. pylori, which fact confirms its leading etiological role in disorders of the stomach and duodenum once again.

Biopsy↗
PubMed1998

[The comparative efficacy of different drug regimens in the treatment of peptic ulcer].

Our objective in this study was a comparative evaluation of efficiency of modern drug alternatives to treat peptic ulcer, based on new algorithms of diagnosis and treatment. The results obtained suggest to us that in a major proportion of cases uncomplicated duodenal ulcers might be efficiently managed in an outpatient-clinic setting even with a two-to-four week monotherapy. The best results of treatment are recordable in those groups of patients having received inhibitors of proton pump.

Adolescent↗
PubMed1992

[Differentiated immunocorrective therapy in nonspecific ulcerative colitis].

A comparative study of the clinico-immunological efficacy of steroid hormones and thymus drugs in 50 patients with unspecific ulcerative colitis of different activity grades revealed that their efficacy was not similar at different phases of the disease and depended on the activity of the inflammatory process. Corticosteroids were more effective in inflammatory-destructive changes in the mucosa of the large intestine while in mild inflammation with prevalence of ulcerative-reparative processes, immunomodulators (thymalin) are preferred.

Adjuvants, Immunologic↗
PubMed1990

[Effectiveness of immunostimulants in nonspecific ulcerative colitis].

Clinical and immunologic efficacies of some immunostimulants (levamisole, sodium nucleinate, thymic preparations) included in therapeutic schemes in nonspecific ulcerous colitis both separately and in various combinations were under study. The efficacy of these stimulants was found to depend on the disease severity and proved to be the highest in the light course. Thymalin and sodium nucleinate showed the highest clinical and immunologic efficacies, particularly if used together. Levamisole administration was associated with frequent side effects and had no essential advantages over basic therapy. This permits a conclusion that immunostimulants are pathogenetically validated in therapy of ulcerous colitis, for they result in reduction or elimination of immunity insufficiency and their administration leads to a positive clinical effect in the majority of cases.

Adjuvants, Immunologic↗
PubMed1990

[The use of millimeter-range electromagnetic radiation for treating peptic ulcer].

The efficacy was studied of treatment of ulcer disease by means of microwave resonance radiation. It was established that this method of treatment has advantages over traditional drug therapy in patients harbouring the ulcer in the duodenum. The authors describe contraindications to the use of this method, determine the duration of treatment.

Adolescent↗
PubMedDate not supplied

[Prevalence of undiagnosed celiac disease in patients with irritated bowel syndrome].

In the article insufficiency of existing patterns of investigation of patients with irritated bowel syndrome (IBS) during differential diagnostics with celiac disease is underlined, that leads to wrong diagnostics and inefficient treatment of patients. Also own data on prevalence of celiac disease in patients with IBS are shown. Determination of the level of specific markers of celiac disease (in our research--antigliadin Ig) is considered to be the optimal method of diagnostic celiac disease in this group of patients.

Adolescent↗
PubMedDate not supplied

[The potentials of echography in the diagnosis of chronic colitis].

Ultrasonic signs of colitis were studied in 24 adults aged 20 to 53 yr and 38 children aged 3-16 yr in whom chronic colitis was diagnosed. 2 adults and three children had ulcerative colitis. The results obtained showed that with the aid of echography it is possible to detect inflammatory lesions in the large intestine as well as to observe the time course of changes in its wall during the course of treatment. Ultrasonic investigation can be of screening type in detecting an inflammatory process in the large intestine, on the one hand, and a method of profound study of changes in its wall, on the other.

Adolescent↗
PubMedDate not supplied

[The principles of administering drug and non-drug treatment methods in peptic ulcer].

As the result of the study optimal schemes of the ulcer disease treatment were elaborated. They include microwave resonance therapy, immunomodulatory and antibacterial drugs with regard to localisation, depth and size of the ulcerous lesion, exacerbation rate, degree of secondary immune disorders and seeding of gastric mucosa with Helicobacter pylori. The treatment suggested allows to shorten the terms of ulcer cicatrization, reduces exacerbation rate and ensures clinico-endoscopic remission in most patients with ulcer disease.

Adjuvants, Immunologic↗