A spectrum of mean-molecular blood serum peptides in rats with experimental toxic hepatitis and parenteral injection of iodinated oil has been studied using the method of gel-filtration on a sephadex G-25. It is established that the toxic hepatitis is characterized by the expressed rearrangement of the stock of mean-molecular peptides with a preferential growth in the blood serum and normalization of their concentrations 24h after the injection of iodinated oil accompanied by attenuation of the organism intoxication phenomena. An increase in the content of mean-molecular peptides was registered 48 hours after the iodinated oil injection.

Acute Disease↗

PubMedDate not supplied

[Middle molecule fraction in the serum of rats with toxic hepatitis].

An increase in the amount of the middle molecular peptide (MM) fraction in the blood serum of rats with experimental toxic hepatitis and normalization of the MM pool after the administration of the amino acid mixture Alvesin "Novy" are shown. The chromatographic spectra of the MM fraction in normal and experimental animals are compared.

Amino Acids↗

PubMedDate not supplied

[Dynamics of free amino acids in rat brain tissue during hypothermia].

A comparative study is conducted for the effect of one-, three- and six-hour artificial deep (20-19 degrees C) hypothermia on the content of free amino acids in the blood serum, tissue, nuclei and mitochondria of the rat brain. It is found out that the content is the highest in the blood serum after a three-hour cooling. In the brain tissue the amount of amino acids lowers, especially under conditions of a six-hour hypothermia. In nuclei a three-hour effect of hypothermia decreases sharply the content of free amino acids and the six-hour one increases the amount of most of them. Under hypothermia the content of nearly all amino acids in the brain mitochondria is higher than in the intact animals.

Amino Acids↗