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Biomedical subjects

S M Vieira

Publications and source records attributed to S M Vieira.

7 recordsLinked to original sources
PubMed2000

[Liver transplantation]

OBJECTIVE: To review the clinical aspects and the theoretical basis of liver transplantation in children, focusing mainly pre and post surgical periods. METHODS: References were obtained from computerized search in the National Library of Medicine (Medline), recent review articles, and personal files. RESULTS: Great development has occurred in surgical techniques, in organ preservation, in postoperative care, and in immunosuppression methods after the first liver transplantation surgery took place in a child with biliary atresia in 1963. Liver transplantation has become an efficient therapy, widely accepted and used in all age groups. It is a very complex procedure, with many professionals involved and with several legal, ethical and economical implications. We review in this article the clinical aspects before transplantation, including indications, contraindications, clinical and laboratory evaluations, as well as postsurgical aspects, both in the immediate period, after the 1st week, and the long-term outcome, discussing the complications and the treatment of each. CONCLUSIONS: Liver transplantation has dramatically improved the survival of pediatric patients with chronic hepatic diseases. Patients of liver transplantation in the pediatric age group present today survival rates of 90% in the different transplantation centers.

Journal Article↗
PubMed1984

Specific attachment of morphologically-distinct intermediate filaments to desmosomes and hemidesmosomes in the epidermis of the tadpole of the anuran, Pseudis paradoxus.

Polarization microscopy disclosed the presence of strongly birefringent intracellular structures in the basal cells of the epidermis of the tadpole of the anuran Pseudis paradoxus. The electron microscopic picture of the birefringent structures showed that they were composed of thick intermediate filaments (average diameter: 11.2 +/- 0.8 nm) oriented in a parallel disposition to form closely packed bundles which attached to the hemidesmosomes present on the basal surface of the cells of the basal layer of the epidermis. Thinner intermediate filaments (average diameter: 8.2 +/- 0.8 nm) were localized to the cortical zone of the cytoplasm; these thinner intermediate filaments converged upon the sites of cell-to-cell adhesion (desmosomes).

Animals↗
PubMedDate not supplied

[Follow-up of pediatric patients evaluated for liver transplantation].

OBJECTIVE: To analyze the evolution of pediatric patients chosen for hepatic transplantation. METHODS: A review was made of the clinical charts of the first 65 children and adolescents with chronic liver disease, aged 5 months to 19 years (X = 6.8%), chosen for liver transplantation during the period of August 1994 to March 1996. Data refer to the patients' demographic characteristics, etiology of their liver disease, their psychosocial situation and of their parents, and their clinical and laboratorial evaluation. According to the severity of the disease, patients were classified as active (waiting for a donor), in evaluation, inactive (compensated liver disease), and excluded for psychosocial or medical conditions, or because of bad indication. RESULTS: Eight patients (12%) received transplantation, and one of them died. Seven (11%) died when in evaluation or waiting for a donor. Ten patients (15%) were excluded from the waiting list: 6 for social problems, and 4 for medical problems. No patient was excluded for bad indication. Six patients are in the active list, waiting for donor. The other 23 patients (35%) are in evaluation, and 11 (17%) are classified as inactive in the waiting list. CONCLUSIONS: Eleven patients (17%) were not operated on due to the advanced stage of the liver disease. We emphasize the necessity of organ donation, and the early contact of the patients with a reference center.

English Abstract↗
PubMedDate not supplied

[Management of AIDS during traditional hospitalization and at outpatient clinics in Recife (Brazil)].

The management of 50 AIDS patients by traditional hospital admission (25 cases) and outpatient clinics (25 cases) was studied between August and November 1995 in the Department of Infectious and Parasitic Diseases of the Federal University Hospital. The most costly items of expenditure were hospital services and consumable materials. Comparison of costs was complicated by differences in clinical status of the patients in the two groups. The choice of treatment was much more dependent on clinical status than on sociodemographic factors. Traditional hospital admission tended to be associated with the poorest patients. The rationalization of care based on cost-benefit analysis requires much future work.

Acquired Immunodeficiency Syndrome↗