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Biomedical subjects

S M Wasan

Publications and source records attributed to S M Wasan.

12 recordsLinked to original sources
PubMed1998

Acute bacterial endocarditis following burns: case report and review.

Acute bacterial endocarditis (ABE) is a rare but deadly complication following major thermal injury. Typically the presentation is silent, with persistent fever and positive blood cultures being the only consistent findings. Fibrin-platelet vegetations on the valvular endocardium are thought to be seeded during bacteremic episodes. Manipulation of the burn wound is probably the most likely source of bacteremia, with Staphylococcus aureus and Gram-negative bacilli being the most commonly implicated bacteria. In addition to causing local damage to a valve or the myocardium, infected vegetations may dislodge septic emboli systemically. Diagnosis is most easily obtained by echocardiography. Treatment usually involves prolonged administration of intravenous antibiotics. In rare circumstances, valvular resection and replacement may be indicated.

Acute Disease↗
PubMed1990

Sodium loading treatment for amphotericin B-induced nephrotoxicity.

The increased frequency and duration of antifungal treatment with amphotericin B in immunocompromised patients has stimulated a great deal of research into the mechanisms of its nephrotoxic effects and treatment modalities designed to attenuate these effects. A review of amphotericin B-induced nephrotoxicity, the underlying pathophysiologic mechanisms, and the role of salt loading as a means of minimizing renal impairment are described. Both animal and human studies regarding the efficacy of sodium loading are presented as well as a case report describing the use of salt supplementation over a prolonged course of therapy.

Amphotericin B↗
PubMed1983

Ultrastructural effects of topical timolol on the rabbit cornea. Outcome alone and in conjunction with a gas permeable contact lens.

Corneal epithelial erosions developed in two patients wearing gas permeable contact lenses (Boston) soon after commencing topical timolol maleate therapy. This prompted the following investigation. Forty rabbit corneas were examined by scanning and transmission electron microscopy after treatment for one month with one of the following: timolol ophthalmic solution, preservative-free timolol, contact lens, contact lens and timolol, contact lens and preservative-free timolol, contact lens and saline, or no treatment. Corneas treated with either timolol or contact lens alone showed mild to moderate edema or degeneration of epithelial and endothelial cells. However, the combined use of a contact lens and timolol produced marked alterations in both the corneal epithelium and endothelium.

Administration, Topical↗
PubMed1981

Corneal epithelial dysplasia and carcinoma in situ.

Corneal epithelial dysplasia and carcinoma in situ have not been emphasized as distinct clinical conditions in the literature. Seven cases are presented with their clinicopathological correlation. Six of the patients presented primarily with corneal signs and symptoms consisting of notable visual blurring or foreign body sensations, or both. Biomicroscopic examination revealed a geographic, diffuse, greyish-white haze involving the corneal epithelium, often with; subtle thickening and irregularity of the involved areas and overlying superficial punctate keratitis. Histologic examination showed all degree of corneal epithelial dysplasia up to carcinoma in situ. The diagnosis, course and management of these conditions is discussed.

Adult↗
PubMed1980

Glucose substrate in myocardial protection.

Glucose-insulin-potassium (GIK) was infused preoperatively in 30 patients scheduled for coronary artery operation. Before cardiopulmonary bypass (CPB) each patient received an intravenous infusion of 50% glucose. Myocardial protection was achieved with a cardioplegic solution containing glucose. A similar group of 30 patients received an equal volume of NaCl infused preoperatively and before CPB, and their cardioplegic solution contained no glucose. Clinically and by hemodynamic evaluation postoperatively one could not separate the two groups. Glycogen grading of the myocardium prior to bypass demonstrated no difference in glycogen levels in patients receiving glucose and those receiving NaCl. However, at the end of cardioplegic arrest only the group receiving glucose maintained normal grading of myocardial glycogen.

Biopsy↗
PubMed1979

Prosepctive analysis of heart biopsies in coronary artery surgery.

In a prospective analysis of 36 biopsies from human hearts performed at the time of elective coronary operation, several morphological changes were identified in the myocardium. Some of these changes (fibrosis, vacuolation, edema, and amyloid deposition) are of clinical signficance and may affect the long-term prognosis for patients undergoing revascularization procedures. It appears, therefore, that knowledge of the morphological state of the myocardium at the time of operation can prove useful in elucidating further the long-term effects of coronary artery bypass on the left ventricular myocardium.

Adult↗
PubMed1979

Intraoperative transmural myocardial biopsy: a simple technique.

A Tru-cut disposable biopsy needle was used in 10 pigs, 3 cadavers and 63 humans to obtain transmural ventricular myocardium for diagnostic and research purposes. The technique proved simple and safe. In every case an adequate amount of full-thickness myocardium was obtained which was examined by light and electron microscopy and used for enzyme studies and glycogen measurement.

Animals↗