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Biomedical subjects

S M Watkins

Publications and source records attributed to S M Watkins.

At least 37 records · Page 2Linked to original sources
PubMed1978

High incidence of vincristine-induced neuropathy in lymphomas.

The incidence of vincristine-induced neuropathy was studied in 60 unselected patients, of whom 23 had lymphoma and 37 had other malignant disease. All were treated with vincristine combined with other cytotoxic agents. Fourteen of the patients with lymphoma (61%) developed neuropathy compared with five patients with leukaemia or non-lymphoid cancer (14%), even though all patients received comparable doses of vincristine. The difference between the two groups in the incidence of neuropathy was highly significant. Of the patients who developed neuropathy, 17 did so within the first three months of treatment and seven in the first month. Patients with lymphoma who are receiving vincristine should be observed carfully for symptoms and signs of neuropathy. Vincristine should be withdrawn if progressive neurotoxicity develops.

Age Factors↗
PubMed1978

Lymphocyte transformation in cancer patients: variation in results according to technique.

Lymphocyte transformation to phytohaemagglutinin (PHA) was measured simultaneously by two methods (heparin and methyl cellulose) in 16 patients with non-lymphoid cancer and 21 normal subjects. Twelve cancer patients showed transformation levels below the normal heparin range, but only two patients showed levels below the normal methyl cellulose range. These findings suggest that in interpreting lymphocyte transformation studies close attention should be given to the methods employed.

Adolescent↗
PubMed1976

Cancer prognosis predicted by preoperative lymphocyte responsiveness in vitro.

The prognosis in cancer patients was studied in relation to their preoperative cell-mediated immune status. Thirty patients with various types of operable cancer were studied. Transformation of the lymphocytes in response to phytohaemagglutinin (PHA) in vitro was measured preoperatively. All the patients were followed up for 3 years. Those with normal preoperative lymphocyte responsiveness had a far better prognosis than those in whom this test was subnormal.

Follow-Up Studies↗
PubMed1972

Serum enzyme levels in diagnosis of postoperative myocardial infarction.

The levels of creatine kinase, hydroxybutyric dehydrogenase, and aspartate transaminase have been serially measured in the serum of patients undergoing surgery. Serum enzyme levels often rose to a range commonly found after myocardial infarction but fell to normal within 5-10 days. Raised serum enzyme levels have no diagnostic significance in a case of postoperative chest pain until after the fifth postoperative day, but may be significant thereafter.

Adult↗