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Biomedical subjects

S M Wolff

Publications and source records attributed to S M Wolff.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

Effect of prophylactic colchicine therapy on leukocyte function in patients with familial Mediterranean fever.

Patients with familial Mediterranean fever (FMF) who were part of a double-blind trial of daily colchicine as prophylaxis for their disease had leukocyte functions studied while receiving colchicine or placebo. Leukocytes taken from these patients while on prophylactic doses of colchicine produced normal quantities of leukocytic pyrogen, ingested bacteria normally, and migrated normally in chemotatic chambers. In addition these patients had normal numbers of circulating T and B lymphocytes as well as normal blastogenic reponses of their peripheral lymphocytes to mitogenic stimuli. The patients on colchicine, however, had significantly fewer neutrophils and monocytes accumulating at skin-window sites 24 hours after the initial abrasion. Because the early phase of the skin-window response was normal in these patients, the decreased late response may be related to a failure to amplify the initial inflammatory reaction. The reduced capacity to generate a normal inflammatory response may account for the failure of these patients to develop full attacks while taking colchicine.

Cell Migration Inhibition↗
PubMedDate not supplied

New concepts on the pathogenesis of fever.

For more than 50 years, experimental studies on fever have focused on a substance from leukocytes called leukocytic or endogenous pyrogen. Various investigators concluded that changes associated with infection--such as numbers of circulating leukocytes; levels of trace metals, amino acids, and hepatic proteins; and altered lymphocyte function--were also caused by endogenous leukocyte mediators. There was reasonable evidence that fever and these other changes were brought about through the action of a single endogenous pyrogen, now known as interleukin 1 (IL-1). Two forms of IL-1 have been cloned (IL-1 beta and IL-1 alpha), and studies of recombinant IL-1 preparations have confirmed that fever and the broad spectrum of host responses to infection and injury are indeed mediated by this substance. However, IL-1 is not the only leukocyte product that induces fever: tumor necrosis factor (cachectin) and interferon produce fever in humans and animals. Accordingly, the concept of a single endogenous pyrogen now requires modification. Nature has conferred the ability to produce fever on no fewer than three structurally distinct molecules. Investigators trying to determine what triggers the hypothalamus to initiate fever in a particular disease must now consider these three endogenous pyrogens, either alone or together, as mediators of fever.

Acute-Phase Reaction↗
PubMedDate not supplied

Curriculum guidelines for AIDS education of primary care practitioners: outcome of an authority opinion survey.

Curriculum guidelines for the education of primary care practitioners (PCPs) about AIDS and AIDS-related disorders have been developed by the National Fund for Medical Education (NFME). The guidelines resulted from a modified Delphi authority opinion survey with two iterations and have been edited by the authors. The guidelines are intended to support local educational programming in hospitals, medical schools, HMOs, health departments, and other entities that provide educational services to physicians and nurses. The guidelines are intended to be flexible so as to support programs directed at issues of particular local interest as well as more general programs. The guidelines are divided into 12 modules and cover epidemiologic, scientific, clinical, social, and economic issues related to AIDS and HIV infection. NFME will provide, on request, a list of potential faculty who can teach the various modules.

Acquired Immunodeficiency Syndrome↗