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Biomedical subjects

S Müller-Lissner

Publications and source records attributed to S Müller-Lissner.

70 records · Page 4Linked to original sources

[Disorders of stomach emptying].

During the course of viral infections, acute delays in gastric emptying are common. Usually, dietary measures suffice, but treatment with dopamine antagonists with their additional antiemetic effect, may be beneficial. The major causes of chronic delayed emptying are diabetes mellitus with autonomic neuropathy, connective tissue diseases such as systemic sclerosis, and gastroparesis following gastric surgery. Diet alone is rarely effective, and prokinetic drugs should be prescribed. The new compound cisapride seems to be particularly effective. Abnormally rapid emptying occurs exclusively following surgical destruction of the gastric outlet and may lead to the dumping syndrome. In general this can be adequately controlled by dietary measures.

Diagnosis, Differential↗

Evaluation of the usefulness of dimethicone and/or senna extract in improving the visualization of abdominal organs.

Intestinal gas is the most common cause of technically unsatisfactory abdominal ultrasound scans. In the attempt to increase the visualization of abdominal organs, many investigators use antifoaming agents or laxatives. In the present, randomized, placebo-controlled, double-blind trial, a liquid dimethicone preparation and an extract of senna, alone and in combination, were tested as a means to improve scan quality. Response variables were defined on the basis of pancreas, aorta, and kidney visibility. There was no difference in the response variables of the three groups compared to placebo (P greater than 0.3-0.55). The results suggest that neither dimethicone nor senna improves the visibility of abdominal organs in ultrasound examination.

Abdomen↗

[Motility disorders of the esophagus].

The paper describes the physiology of swallowing, the methods for the assessment of esophageal motility, and the motility disorders of the tubular part and the lower sphincter of the esophagus, except for gastroesophageal reflux disease. Primary esophageal motility disorders are achalasia (incomplete relaxation of the lower sphincter in response to swallowing), diffuse esophagospasm (simultaneous repetitive contractions), and the nutcracker esophagus (propulsive peristalsis with abnormally high amplitude). Besides, there are non-specific as yet unclassified contraction abnormalities. Since hypermotile contraction abnormalities can mimic chest pain of cardiac origin, differential diagnosis of anginal chest pain should include esophageal motility disorders. Contraction abnormalities of the esophagus may occur in diffuse scleroderma, after therapeutic radiation of the mediastinum, and possibly after sclerotherapy of esophageal varices.

Esophageal Achalasia↗

[Gastric secretory inhibitors improve the visibility of gastric mucosal detail in barium studies of the stomach: a controlled clinical trial (author's transl)].

In a controlled randomized clinical trial the effect of the secretory inhibitors Cimetidine and pirenzepine on the visibility of the areolar gastricae in barium studies of the upper gastrointestinal tract was examined. Both drugs improved the radiological imaging of the areolar tidine reduced the amount of radiologically visible fasting gastric contents. Thus, factors other than the volume alone of gastric secretions appear to play a major role in the quality of imaging of the gastric fine relief.

Benzodiazepinones↗

[Granulocyte function in septicemia of the newborn (author's transl)].

The ingestion- and Nitro Blue Tetrazolium-(NBT)-reduction-capacity of neutrophil leukocytes in three newborn infants with lethal septicemia was studied using a modified NBT-test. In comparison to 25 controls in healthy newborns (umbilical vein-blood) the results indicate a failure in the functioning of leukocytes. Besides other disturbances the impaired ingestion- and NBT-reduction-capacity of the neutrophil granulocytes during an infection probably leads to septicemia.

Female↗

[Capacity of nitroblue tetrazolium-reduction of neutrophilic granulocytes (author's transl)].

A modification of the NBT-reaction is described which allows a differentiation of the NBT uptake and NBT-reduction. By means of this method it has been shown that the capacity of NBT-reduction of neutrophil granulocytes taken from hematologically healthy persons is independent of the probands' age and, moreover, of the presence of acute infections and their etiology. It has been shown, that the increase in the NBT-reduction of neutrophilic granulocytes of newborns and persons with acute bacterial infections results from an increased NBT-ingestion. To grive an example of a strongly reduced capacity of NBT-reduction of the neutrophilic granulocytes 2 patients suffering from fatal granulomatous disease in childhood have been examined.

Age Factors↗