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S Machin

Publications and source records attributed to S Machin.

27 records · Page 2Linked to original sources
PubMed1992

Electrokinetic behaviour and surface sialic acid status of blood platelets in essential thrombocythaemia (ET).

We have previously reported, for platelets from patients with idiopathic thrombocytopenic purpura, that there was in increased electrophoretic mobility that was related to their increased sialic acid content. Heterogeneity in the circulating platelet pool of patients with essential thrombocythaemia (platelet counts 600-1000 x 10(9)/l) has also been investigated by preparative continuous flow electrophoresis (CFE). The surface charge-dependent separation profiles of all the patients' platelets showed marked anodal shifts compared with the profiles of platelets from age- and sex-matched control subjects separated under identical conditions. The increase above normal in the net electronegativity of the patients' platelets could not be accounted for by differences in surface neuraminidase-labile or total platelet sialic acid content.

Blood Platelets↗
PubMed1991

Electrokinetic properties and surface membrane sialic acid status of platelets in idiopathic thrombocytopenic purpura (ITP).

Continuous flow electrophoresis has been used to investigate heterogeneity in the circulating platelets from patients with idiopathic thrombocytopenia (ITP) and from age- and sex-matched control donors. The ITP patients' platelet counts ranged from 15 to 80 X 10(9)/l and they had much higher mean volumes and significantly higher (two-fold) total cell and neuraminidase-labile surface sialic acid contents expressed per unit cell than normal. After volume normalization the mean difference between the two groups was not statistically significant. The relationships of these findings to abnormal thrombopoiesis and to molecular recognition for reticuloendothelial system (RES) removal are discussed.

Adolescent↗
PubMed1988

The haematological values of European badgers (Meles meles) in health and in the course of tuberculosis infection.

Captive, healthy, adult badgers have blood containing haemoglobin at 13.3 g/dl, and 8.4 x 10(12)/l red cells with an MCV of 46.2 fl and an MCH of 15.6 pg. They have 5.1 x 10(9) white cells/l of which 3.29 x 10(9) are polymorphs, 1.49 x 10(9) are lymphocytes, 0.26 x 10(9) are monocytes, 0.07 x 10(9) are eosinophils and 0.01 x 10(9) are basophils. These values are somewhat less in adult animals just trapped from the wild, and are lower still in wild cubs. Changes associated with tuberculosis are a rise, and then a fall in red blood count and white blood count, an increase in the proportion of polymorphs and monocytes and a fall in lymphocytes late in the disease. This picture is similar to that seen in widespread, disseminated, tuberculin negative, tuberculosis in humans, a type of disease similar to that occurring in many badgers. BCG vaccination of badgers did not produce any measurable change in the blood picture.

Animals↗
PubMed1987

Platelet hyperaggregability in a patient with Klinefelter's syndrome and leg ulcers.

We describe a patient with Klinefelter's syndrome complicated by recalcitrant leg ulcers, in whom marked platelet hyperaggregability was demonstrated and venous disease excluded. Androgen replacement therapy appeared to bring about healing of the patient's ulcers and was associated with reversal of the platelet abnormality. The possible role of androgen deficiency in the pathogenesis of leg ulceration is discussed.

Adult↗
PubMed1984

Therapy of Waldenström's benign hypergammaglobulinaemia by regular plasmapheresis.

A patient with a 20-year history of Waldenström's hypergammaglobulinaemic purpura has over that time developed increasingly troublesome clinical symptoms of purpura and joint swelling, associated with a progressive increase in the level of polyclonal IgG. These symptoms have been controlled by the use of a regular plasmapheresis regime and associated with a reduction in IgG levels.

Adolescent↗
PubMedDate not supplied

Collaborating with the consortium: the development of a foundation in critical care skills programme.

This paper outlines the role and function of NHS education and training consortia and how one consortium is addressing the issues of supporting practitioner-led, practice-based training initiatives in critical care. In late 1997 the consortium sought to identify current problems with recruitment and retention of competent critical care nurses, access to training and development and to examine the quality and appropriateness of current pre- and postregistration training related to the critical care areas. A number of issues were identified, with the need for a Foundation in Critical Care Skills Programme' for junior nurses as the principle short term priority. A programme supported by the local consortium, in collaboration with seven NHS trusts' critical care areas (totalling 27 different departments/units), has been developed, incorporating skills workshops, completion of open learning materials, assessments of core competencies and the submission of a portfolio of evidence in support of a professional award (ENB Certificate). The importance and value of collaboration in the development of this practitioner-led consortium-supported venture is highlighted.

Cooperative Behavior↗