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Biomedical subjects

S Magnússon

Publications and source records attributed to S Magnússon.

7 recordsLinked to original sources
PubMed1999

Indicators of health and well-being in Iceland and Sweden. A comparative study of various indicators concerning standards of living and mortality.

OBJECTIVE: To study various indicators concerning health and well-being in two Nordic countries with special attention to standards of living and mortality. DESIGN: Comparative study of the mortality rates from various causes of death during the years 1983-1992 and some indicators of standard of living derived from official reports and registers in Iceland and Sweden. SETTING, SUBJECTS: The total populations of Iceland and Sweden. MAIN OUTCOME MEASURES: Mortality rates, indicators of living standard, gross domestic product and demographic variables such as divorces and unemployment. RESULTS: The mortality rates for all causes of death were similar for women in Iceland and Sweden during 1983-1992 but were lower for men in Iceland than in Sweden. The mortality rates from cardiovascular diseases decreased during the study period. The rates for malignant disease were higher in Iceland for both men and women. Iceland has a larger population growth but a much lower population density. Most of the demographic variables were similar in the two countries. Unemployment rates were higher in Sweden. CONCLUSION: In spite of large similarities between Iceland and Sweden in socio-demographic variables there are substantial differences in mortality rates between the countries. The causes for these mortality differences are obscure and should be further investigated.

Cause of Death↗
PubMed1999

Chronic bronchitis in Icelandic males: prevalence, sleep disturbances and quality of life.

OBJECTIVE: To study the prevalence of chronic bronchitis in Iceland and some aspects of quality of life among those suffering from chronic bronchitis. DESIGN: Postal questionnaires. SETTING, SUBJECTS: All Icelandic males born in the years 1913 and 1943 who were alive on 1 November 1993. Altogether 1175 (69.7%) responded. MAIN OUTCOME MEASURES: Physical symptoms of chronic bronchitis, stress symptoms, symptoms of dyspnea and sleep disturbances. RESULTS: 7.1% of those 50 years old and 16.7% of those 80 years old and a history of daily sputum expectoration for at least 3 months during the preceding 2 years. These individuals with chronic bronchitis had a higher prevalence of other respiratory symptoms than did the others, such as "wheezing or whistling" (59.6% vs. 7.2%), and "awakened by breathlessness" (35.2% vs. 6.0%). Complaints of dyspnea were more common among those with symptoms of chronic bronchitis, e.g. "dyspnea when walking" (19.4% vs. 1.4%) and "stops walking because of dyspnea" (22% vs. 1.6%). They also complained more often of insomnia and daytime sleepiness and found themselves more stressed than those without chronic bronchitis. These symptoms were all more common among the 80-year-old men. CONCLUSION: Our study indicates that chronic bronchitis is a frequent illness among Icelandic males. Men with chronic bronchitis often have decreased quality of life, difficulties in moving and frequently sleep complaints.

Aged↗
PubMed1995

[Trends and traditions in Scandinavian general medicine].

Recent decades have witnessed radical changes both in the workload and in the job description of general practitioners (GPs) in the Nordic countries, and the trend continues. Owing to social changes, particularly the deterioration in health care economy, the GPs will in the future be required to deal with increasing numbers of patients as well as increasingly severe categories of diseases, previously treated at hospital departments and clinics. This will entail increased demands in terms both of the further education of GPs and of the equipment available to them. It will also entail improved and extended cooperation between GPs and consultants, both in matters of overall policy and in the management of individual cases.

Education, Medical, Continuing↗
PubMed1993

Endocytosis of ricin by rat liver cells in vivo and in vitro is mainly mediated by mannose receptors on sinusoidal endothelial cells.

Upon intravenous injection into rats, the plant toxin ricin was rapidly cleared from the circulation by the liver. Among the different liver cell populations, most of the injected ricin associated with the sinusoidal endothelial cells (EC), whereas the liver parenchymal cells (PC) and Kupffer cells (KC) yielded minor contributions to the total liver uptake in vivo. Co-injection of mannan strongly inhibited ricin uptake by the EC, showing that it was mediated by mannose receptors. On the other hand, co-injection of lactose, which inhibits the galactose-specific association of ricin with cells, enhanced ricin uptake by the EC. The carbohydrate-dependency of the EC contribution to the uptake of ricin in vivo was reflected in the carbohydrate-dependency of the uptake in vivo by whole liver. In vitro, the EC also endocytosed ricin more efficiently than did the PC or KC. Whereas uptake in vitro in the EC was mainly mannose-specific, uptake in the two other cell types was mainly galactose-specific. Western blotting showed that the mannose receptors of liver non-parenchymal cells are identical with the mannose receptor previously isolated from alveolar macrophages. The mannose receptors are expressed at a higher level in EC than in KC. Ligand blotting showed that, in the presence of lactose, the mannose receptor is the only protein in the EC that binds ricin, and the binding is mannose-specific and Ca(2+)-dependent.

Animals↗
PubMed1977

Studies on herediatary spherocytosis in Iceland.

Thirty members with typical hereditary spherocytosis (HS) and over 90 apparently unaffected members belonging to 12 families have been studied. Splenectomy has been performed on 22 HS patients. Of nine HS individuals, who had not undergone surgical treatment in 1957, four suffered from temporary severe anaemia, presumably due to aplastic crisis associated with influenza. One of them died, a male 18 years of age. Pedigree studies on one of the families indicate that the HS gene or genes have been transmitted through six generations over the past 200 years. Marked deficiency in the number of affected compared with the apparently unaffected members in the HS families is present. The most striking example of uneven genetic ratio is a sibship of 15 members investigated haematologically, with one suffering from typical HS. Much reduced penetration of the HS gene or the presence of the socalled "mild form" is upheld as the main explanation for the unevenness in the genetic ratio. However, families are also present in which abortions and death at an early age indicated that selection against the affected could also disturb the genetic ratio in HS families.

Adolescent↗