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Biomedical subjects

S Maj

Publications and source records attributed to S Maj.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

[Effect of lack of exogenous methionine on protein synthesis in normal and leukemic leukocytes cultured in vitro].

Experiments were performed on lymphocytes and leucocytes isolated from peripheral blood of healthy donors and on leucocytes from patients with acute myeloblastic and acute lymphoblastic leukaemia. The influence on protein synthesis of methionine depletion in the medium or replacement of methionine by homocysteine was measured in labelling experiments with tritiated valine. The rate of protein synthesis in lymphocytes and leucocytes from healthy donors cultivated in homocysteine--containing medium and stimulated with PHA did not differ significantly in the course of 5 days from the rate of protein synthesis in the basic medium. In leukaemic leucocytes cultivated in vitro in the time period of 34 h in the rate of protein synthesis in homocysteine--containing medium was similar to the rate of protein synthesis in the medium devoid of methionine.

Adult↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. I. Results of intensive chemotherapy of 106 patients with acute leukemia].

In a period of 5 years 106 patients with acute leukemia were treated (93 with acute nonlymphoblastic leukemia and 13 with acute lymphoblastic leukaemia. Four therapeutic programmes were used. Complete remission (CR) was achieved in 41% of patients, including 37% of those with acute non-lymphoblastic leukaemia and 77% with acute lymphoblastic leukaemia. The per cent of remissions obtained using different programmes was similar. During intensive induction treatment 22% of patients died, mainly of infections and bleeding tendency.

Acute Disease↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. V. The effect of intrathecal cytostatic therapy on leukemic changes in the central nervous system].

In a period of 5.5 years from 1975 to 1980 the neurological status of 82 patients with various forms of acute leukaemia was assessed at the Institute of Haematology and in 42 cases central nervous system involvement was found. These patients were treated by intrathecal administration of drugs according to three programmes. Remission after intrathecal treatment was achieved in 31 cases. No improvement of the neurological status was obtained in 31 cases. No improvement of the neurological status was obtained in 4 cases. Forty-eight patients without neurological signs received prophylactically intrathecal treatment which failed to prevent central nervous system leukaemia in 8 cases.

Acute Disease↗
PubMedDate not supplied

[Prognostic importance of DNA histograms of bone marrow cells in acute myeloblastic leukemias].

DNA histograms were studied in bone marrow cells in 25 patients with acute myeloblastic leukaemia before starting treatment. It was found that patients with complete remission showed a significantly higher proportion of cells in phase S of the cellular cycle (22 +/- 3%) than patients who failed to achieve remission (12 +/- 4%). Assessment of DNA citrograms of bone marrow cells may be one of prognostic factors in acute myeloblastic leukaemia.

Adolescent↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. II. Preliminary analysis of the treatment results according to AR and RAMP programs].

Thirty patients with acute non-lymphoblastic leukaemia were treated. They were randomly assigned to treatment according to programme AR (14 patients) and RAMP (16 patients). The groups were comparable for age and haematological state. Complete remission was obtained in 7 patients out of 14 treated by the AR programme and 6 out of 16 treated by the RAMP programme. The median duration of complete remission is as yet 15 weeks and 16 weeks respectively. The toxic side effects during treatment by the AR programme was statistically significantly higher than in the treatment by the RAMP programme. In the first group 42.8% of early deaths occurred, while in the second group 6.2% patients died early.

Acute Disease↗
PubMedDate not supplied

[Treatment of acute leukemias in adults. IV. Treatment results on 375 patients at 9 hematology centers].

On the basis of standardized protocols of the therapeutic results of acute non-lymphoblastic leukaemias in adults sent to the Institute of Haematology in Warsaw from 8 haematological centres in Poland it was demonstrated that complete remission occurred in 34.4% of patients (129 out of 375 cases). The mean survival time of the patients treated intensively according to programmes I, II, III and IV 8.6 months, those of patients with complete remission - 13.5 months, patients without complete remission - 3.7 months. The most frequent cause of death (82.5%) were infections and/or haemarrhagic diathesis.

Acute Disease↗
PubMedDate not supplied

[Cyclosporin in the treatment of idiopathic aplastic anemia].

Five patients with aplastic anemia were treated with cyclosporine A. In four cases a positive response was noted. In three out of these patients frequency of blood transfusions was decreased. Platelet count increased to 50 x 10(9)/L in two cases and in one case agranulocytosis disappeared. Synergistic effect of cyclosporine A with oxymetholone and prednisone was seen. In one case an improvement lasted only for 1 year. Hepatotoxicity being a complication of therapy was noted in one patient.

Adult↗