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Biomedical subjects

S Manaka

Publications and source records attributed to S Manaka.

At least 19 recordsLinked to original sources
PubMed1979

The role of extracellular potassium in early epilepsy.

Clinical studies indicate that early epilepsy after injury may be associated with some transient and reversible pathophysical processes of the brain. It has been proposed that epileptogenesis in the neocortex and hippocampus may be related to potassium ion accumulation in extracellular spaces. To investigate this hypothesis, we measured [K+]0 using potassium-sensitive microelectrodes in the sensorimotor cortex of cats during early seizures induced by trauma. The [K+]0 increases associated with seizure activity ranged from 14.6 to 25.1 mM, and these were significantly higher than those unassociated with spikes or seizure discharges. Moreover, high K+ solutions (15 mM or more) directly applied to the cortex produced spiking and seizures. These results seem to support the hypothesis that accumulation of [K+]0 is related to development of early epilepsy.

Animals↗
PubMed1978

[Measurement of cerebral blood flow with hydrogen clearance method: technique and a comparative study with the venous out flow method (author's transl)].

Local cerebral blood flow was measured with hydrogen clearance method in fifteen dogs and compared to direct measurement obtained by Michenfelder's venous out flow method. The sagittal sinus was exposed by a midline frontooccipital incision and extensive craniectomy. A tappered catheter was passed in to the superior sagittal. sinus. For measuring hydrogen clearance, platinum wire electrodes with a red tip of 0.5 mm in length and 0.3 mm in diameter were introduced into the parietal and occipital cortex. About ten percent hydrogen gas was given directly into the endotracheal tube for three to five minutes and the obtained clearance curves were transferred to semilog graph papers. Total cerebral blood flow was caliculated by bicompartmental analysis and compared to the two minutes initial slop index. The results are as follows. 1) A linear regression analysis of flows caliculated from the initial slope and bicompartmental analysis shows a high correlation coefficient. 2) There is a high correlation between flows caliculated from electrodes used at the same experiments. 3) Cerebral blood flow from the initial slope measured by hydrogen clearance method shows a high correlation wit flows caliculated from Michenfelder's venous out flow method.

Animals↗
PubMed1977

Skull tumor simulating sinus pericranii. Case report.

A case of skull tumor simulating sinus pericranii is presented. The tumor was situated in the occiput near the midline and it was thought to satisfy the diagnostic criteria of sinus pericranii. At operation the tumor proved to be eosinophilic granuloma with intratumorous hemorrhage associated with epidural hematoma.

Child, Preschool↗
PubMed1977

[Dural arteriovenous malformation in posterior fossa treated with artificial embolization using a liquid silicon rubber, phycon (author's transl)].

Many cases of dural arteriovenous malformation have been reported recently. However, the surgical treatment for these diseases has not been established yet. We propose a new method of treatment on this peculiar vascular diseases, that is one of the artificial embolizations; A catheter is inserted into feeding artery, from which liquid silicon rubber, Phycon, is injected. The rubber is hardened in the vascular net-work. It can not pass into drainer because of its viscosity. Therefore the malformation never develope again. We tried this new method on 46-year-old woman, who suffered from subarachnoidal bleeding, tinnitus and headache. The left common carotid and vertebral angiography revealed dural arteriovenous malformation in posterior fossa (Fig. 1); the feeding arteries of which were middle meningeal arteries, occipital artery, and tentorial artery, etc; the drainers were transverse and sigmoid sinuses. We treated for this case with above-mentioned method; The liquid plastic of 1 - 2 ml injected into each of the main feeding arteries, namely two middle meningeal arteries and occipital artery. Postoperative angiograms revealed this technic was convenient and sufficient for the treatment of dural arteriovenous malformations (Fig. 7).

Cranial Fossa, Posterior↗
PubMed1976

Spontaneous cerebrospinal fluid otorrhea.

A case of spontaneous cerebrospinal fluid otorrhea with recurrent meningitis is reported. The route of cerebrospinal fluid leak was through the internal auditory meatus. The cerebrospinal fluid otorrhea was stopped by packing the meatus with muscle and Gelfoam.

Bacterial Infections↗
PubMed1976

[A case of spontaneous CSF otorrhea associated with recurrent meningitis (author's transl)].

A 5-year-old girl was admitted to our hopsital on June, 1972, because of meningitis and CSF otorrhea. She had not suffered from head trauma or otological infective disease. Right temporal craniotomy was carried out on October, 1972, but no pathological findings on the anterior surface of the petrous bone was detected, so, the right middle ear bottom was packed with fascia graft by otologist, which stopped the CSF otorrhea for seven months. But the otorrhea recurred on June, 1973, when she caught cold. She was readmitted to our hospital because of recurrent meningitis. On November 7, 1973, when the meningitis abated, posterior fossa exploration was performed microsurgically. Strong arachnoid adhesion due to recurrent meningitis and enlargement of the right internal auditory meatus was observed. Probe could be inserted into the internal auditory meatus easily at a depth of 1.5 cm. Saline which was injected into the meatus from the probe flowed into the right middle ear. So the internal auditory meatus was packed with Gelfoam and muscle piece. By means of this procedure, CSF otorrhea was healed completely. Spontaneous CSF otorrhea, which was initially reported in 1897 by Escat, is a very rare disease. Only 15 cases have been reported in the literature. Two main possible routes of CSF leakage were reported, the one is via the internal auditory meatus, the other is via the cochlear aqueduct (Fig. 3). The former cases were more frequent than the latter. Our case belongs to the former type. (Fig. 4)

Cerebrospinal Fluid Otorrhea↗
PubMed1976

[Occipital tumor simulating pericranial sinus (author's transl)].

A case of occipital tumor simulating sinus pericranii was reported. The patient was a 4-year-old girl who suffered from headache and nausea following head injury on midoccipital tumor, but had no remarkable neurological deficit. Her occipital tumor was soft, compressible redish and cyst-like without bruit. Conray cystography of this tumor showed superior sagittal sinus like shadow (Fig. 4). Total removal of the tumor associated with epidural hematoma was performed. Histologically this tumor was confirmed as eosinophilic granuloma. Pathogenesis of this case is following, since patient's tumor was blowed, intratumor-bleeding occurred cosequently and the bleeding flowed into epidural space. So the tumor simulated sinus pericranii (Fig. 5.).

Brain Diseases↗