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Biomedical subjects

S Mandelbaum

Publications and source records attributed to S Mandelbaum.

30 records · Page 2Linked to original sources
PubMed1986

Ulcerative keratitis associated with contact lens wear.

A review of 573 cases of ulcerative keratitis cultured at the Bascom Palmer Eye Institute from January 1977 through September 1982 showed that 118 cases (21%) were associated with contact lens wear; of these, 64 were culture-positive. Of these culture-positive cases, 50 (78%) were caused by gram-negative bacteria, nine (14%) by gram-positive organisms, and two (3%) by fungal organisms. Of the 264 culture-positive ulcers not associated with contact lens wear, 119 (45%) were caused by gram-negative bacteria, 74 (28%) by gram-positive organisms, and 63 (24%) by fungal organisms. These statistically significant differences suggested that the organisms associated with ulcerative keratitis within our geographic region are modified by contact lens use. Pseudomonas was the organism most frequently isolated from ulcers associated with contact lenses and was responsible for nearly two thirds of the culture-positive cases.

Contact Lenses↗
PubMed1986

Late development of ulcerative keratitis in radial keratotomy scars.

We describe three patients in whom ulcerative keratitis developed seven months to 2 1/2 years after uncomplicated radial keratotomy. All ulcers occurred along keratotomy scars within the interpalpebral fissure or inferiorly. At least one case developed spontaneously; another patient may have sustained an unrecognized corneal injury. The third patient was using an extended-wear soft contact lens for correction of residual myopia. Bacteria were isolated from two of the ulcers. With therapy, all ulcers healed without reducing visual acuity. We hypothesize that the altered structure of the slowly healing keratotomy incisions coupled with redistribution of the tear film due to changes in corneal topography may result in intermittent epithelial irregularities. Alone or in conjunction with any form of mechanical or hypoxic corneal injury, these changes along keratotomy incisions may predispose to corneal infection.

Adult↗
PubMed1986

Pseudophakic endophthalmitis. Diagnosis and management.

Eighty-three cases of endophthalmitis occurring in eyes with intraocular lenses are presented. A problem with the cataract section was felt to contribute to development of the endophthalmitis in 22% of patients. Seventy-five percent of eyes were culture positive with a microbiologic spectrum similar to other reported series without lens implants. Staphylococcus epidermidis was the most common organism accounting for 38% of the isolates. Therapeutic vitrectomy was performed in 46 cases (55%), generally in those eyes with the most severe inflammation. Intraocular lenses were removed in 23 cases (28%), usually to facilitate vitrectomy. Only 1 of 57 eyes with bacterial endophthalmitis could not be sterilized while the intraocular lens was retained. Visual acuity of 20/400 or better was achieved in 63% of culture positive cases, in 78% of eyes infected with S. epidermidis, and in 94% of culture negative eyes.

Aged↗
PubMed1986

Snailtracks of the corneal endothelium.

An unusual pattern of corneal endothelial cell alterations has been observed at the slitlamp in eyes following intraocular surgery. Because of their appearance, we have called these changes "snailtracks". We have commonly seen these snailtracks following extracapsular cataract extraction. Similar changes have been noted in cadaver corneas stored in McCarey-Kaufman (M-K) medium. This study presents information which suggests that these changes represent corneal endothelial cell damage.

Cataract Extraction↗
PubMed1985

Late onset endophthalmitis associated with filtering blebs.

Thirty-six cases of late onset endophthalmitis in patients with filtering blebs are presented. Onset of endophthalmitis ranged from 4 months to 60 years after bleb formation. Possible contributing factors could be identified only in a minority of patients. Aqueous, vitreous or both were cultured in all cases. Eighty-three percent of eyes were culture positive. Streptococci were the most frequent causative organisms, isolated from 57% of culture positive eyes. Twenty-three percent of eyes grew Hemophilus influenzae. Only two cases were caused by staphylococci. In general, the visual outcome was poor, probably primarily due to the virulence of the infecting organisms. Endophthalmitis remains a risk even many years after creation of a filtering bleb. The microbiologic spectrum in this clinical setting is considerably different from that of recent postoperative endophthalmitis. Based on the bacteriology and clinical course of the patients presented, recommendations for management are discussed.

Adolescent↗
PubMed1983

Mucous membrane grafting for severe palpebral vernal conjunctivitis.

Vernal conjunctivitis usually can be managed medically. In the rare cases that do not respond to medical treatment, surgical intervention has been considered. Four cases of vernal conjunctivitis and one case of probable contact lens-induced giant papillary conjunctivitis were treated with palpebral conjunctival excision and application of a mucous membrane graft. All patients improved symptomatically, with follow-up ranging from 1 1/2 to 14 years. The only complication encountered was recurrence of giant papillae at the conjunctiva-mucous membrane graft junction. Conjunctival excision and mucous membrane grafting is a useful procedure in rare cases of particularly severe vernal conjunctivitis.

Adult↗
PubMed1983

A specular microscopic viewing system for donor corneas.

A system for routine specular microscopic assessment of donor corneal endothelium including a chamber that allows both storage and viewing of the donor tissue was evaluated. A specular microscope modified to enable noncontact scanning of donor cornea from the endothelial side was used. Forty-five human corneas were examined upon arrival at the eyebank. Storage in the new chamber was compared with that in standard vials for 13 paired corneas. This study demonstrates the feasibility and simplicity of routine specular microscopy on donor corneal tissue, and discusses its advantages.

Adolescent↗
PubMed1980

Bright-flash electroretinography and vitreous hemorrhage. An experimental study in primates.

Serial, bright-flash electroretinograms (ERGs) were recorded from rhesus monkey eyes before and after a standard posterior penetrating ocular injury and injection of 0.5 mL of blood into the vitreous. This procedure resulted in a progressive depression to virtual nonrecordability of the ERG during a period of several weeks, owing to a combined progressive increase in optical density and loss of retinal function. The ERG depression, however, was reversible, showing a remarkable recovery during the subsequent four to eight weeks. These findings suggest that in the presence of a recent, massive vitreous hemorrhage, a nonrecordable bright-flash ERG does not necessarily indicate a permanent loss of retinal function.

Animals↗
PubMedDate not supplied

Lymphomatoid granulomatosis with ocular involvement.

Lymphomatoid granulomatosis is an angiocentric and angiodestructive lymphoproliferative disorder that involves multiple organs including the lung, skin, kidney and central nervous system. A case of lymphomatoid granulomatosis with ocular involvement is reported herein. Bilateral peripheral retinal vasculitis involving both arterioles and veins, with posterior uveitis, is the prominent clinical finding.

Adult↗