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Biomedical subjects

S Marchese

Publications and source records attributed to S Marchese.

35 records · Page 2Linked to original sources

[Bio-imaging for the study of organic changes in the C.N.S.: comparison between computerized tomography and magnetic resonance].

Several comparative studies have been carried out in order to evaluate the possible diagnostic superiority of Computed Tomography (C.T.) vs. Magnetic Resonance Imaging (M.R.I.) in different diseases of the Central Nervous System. The present investigation is aimed at critically revising this problem also including the study of patients clinical data as a criterion of choice. A sample of 69 subjects was examined. It was seen that in demyelinative as well as in chronic cerebrovascular diseases M.R.I. should be preferred because of its higher sensitivity and specificity. Concerning specifically chronic cerebrovascular diseases, clinical data can have a more significant role in justifying the choice of M.R.I. C.T., and M.R.I. should be considered as complementary rather than competitive in studying cerebral tumors and spinal cord pathology; the planning of surgical operations, needing a complete evaluation of data, which in these cases are very variable, requires the use of both methods.

Central Nervous System Diseases↗

The effect of trisomy 18 on transverse cerebellar diameter.

The transverse cerebellar diameter was measured in 19 fetuses with trisomy 18. Eleven of the cerebellar measurements (57.9%) were greater than 2 SD below the mean for the patient's gestational age. If fetal biometry rather than last menstrual period were used to determine gestational age, four of the 19 (21.0%) cerebellar measurements were greater than 2 SD below the mean. Both intrauterine growth retardation and intrinsic central nervous system abnormalities associated with trisomy 18 appeared to affect cerebellar size.

Cerebellum↗

Deletion of terminal portion of 6q: report of a case with unusual malformations.

We present the necropsy findings of a 21-week-gestation male fetus with deletion of the terminal portion of long arm of chromosome 6 [46,XY,del(6)(q23----qter)]. Major anomalies include intrauterine growth retardation, facial anomalies, nuchal cyst, scoliosis, bilateral diaphragmatic hernias, persistent common atrioventricular canal, absent olfactory bulbs and agenesis of corpus callosum. In aberrations of chromosome 6q, patients usually have psychomotor retardation, somatic growth failure, and facial anomalies; nuchal cyst and bilateral diaphragmatic hernias have not yet been described.

Abnormalities, Multiple↗

Increased amnionic fluid alpha-fetoprotein due to a holoacardium amorphous twin.

Amnionic fluid alpha-fetoprotein measurement was employed as a screening test for neural tube defects in a pregnancy only at risk due to advanced maternal age. The alpha-fetoprotein concentration was elevated more than 10 standard deviations above the mean and was found to be caused by a holoacardium amorphous twin. A normal female fetus was also present. Various causes of elevated alpha-fetoprotein concentration in amnionic fluid are discussed.

Abnormalities, Severe Teratoid↗

Liquid chromatographic/mass spectrometric determination of desmedipham and phenmedipham and their metabolites in soil.

A simple method is described for the simultaneous determination of residues of 2 carbamate herbicides (phenmedipham and desmedipham) and related metabolites (m-aminophenol, aniline, and m-toluidine) in soil. The analytes are extracted from spiked soils with methanol. The solvent/soil suspension is centrifuged, and the supernatant is directly injected, without any further cleanup, into a reversed-phase liquid chromatography/mass spectrometry apparatus equipped with a TurbolonSpray interface. The method was tested on 5 soils having different physicochemical properties. Recoveries from the soil types, spiked over the range of 50-200 ppb, were essentially quantitative for each analyte. The detection limits of the method are < or = 25 ng/g.

Carbamates↗