PubMed Health⌕ Search

Biomedical subjects

S Markaki

Publications and source records attributed to S Markaki.

33 records · Page 2Linked to original sources
PubMed1993

Autopsy findings in burn injuries.

Over a 4-year period (1986-1990) forty autopsies of burned patients were performed. The male to female ratio was 1:2.3. The age ranged between 20-95 years. (57.5% of them belonging to the 61-95 age-group). The total burn surface area ranged between 20% to 95% and 26 patients (65%) had major burns (41-95% total burn surface area). Twenty-three of our patients survived for 1 to 10 days following the accident, eleven died between days 11-40 post burn and six patients survived the 41st post burn day. Almost 70% (28 cases) of our patients presented inhalation injury, and half (20 cases) presented multiple organ failure. The most frequently affected organ was lung (38 cases), followed by heart (23 cases), kidney (17 cases) and liver (15 cases). Multiple organ failure appeared to be unrelated to the onset and efficacy of fluid replacement. The aim of our study was to demonstrate the importance of close collaboration between the clinician and the pathologist and the clinical correlation between burn autopsy and management and therapy of burn injury.

Adult↗
PubMed1991

Ag-NORs in giant cell tumor of bones: are they useful in the estimation of tumor's behavior?

The number of nucleolar organizer regions (NORs) in giant cell tumors of bones was measured using the one-step silver staining technique (AgNOR) with black and white photographs and semiautomatic image analysis. The purpose of the study was to determine whether this method provides useful information on the biological behavior of bone GCTs. The number of AgNORS in bone CGTs (mononuclear cells: 3.45 +/- 1.17, and multinucleate cells: 2.52 +/- 0.97) was found to be higher than in NOF cells (2.16 +/- 1.02 and 2.01 +/- 0.78) but lower than in MFH cells (4.17 +/- 1.3 and 3.86 +/- 1.24). Statistical analysis showed that differences between GCTs and MFH were highly significant for both mononuclear and multinucleate cells, whereas differences between GCTs and NOF were significant only for mononuclear cells.

Bone Neoplasms↗
PubMed1990

Primary vascular bone sarcomas. A clinicopathological and immunohistochemical study of two cases.

Two cases of primary vascular bone sarcomas are reported. The first case presented a rather slow clinical course and a non-aggressive histological picture and was classified as hemangioendothelioma. The second was a frankly malignant tumor, already metastatic at the time of diagnosis, which was classified as angiosarcoma. Views concerning the nomenclature and the behavior of primary vascular bone sarcomas are also discussed.

Aged↗
PubMed1990

Acute rupture of anterior cruciate ligament: histological study of fifteen cases.

Rupture of the anterior cruciate ligament may lead to functional instability and premature degenerative changes of the knee or, if treatment and rehabilitation are carefully carried out, to a functionally stable knee. In this paper we histologically studied the torn ends of the anterior cruciate ligament from fifteen patients who underwent surgical treatment for acute rupture of the ligament. The interval between the rupture and surgery was 11-20 days. The purpose of this study was to evaluate the time of appearance and the degree of degenerative changes of the torn ends in cases of midsubstance rupture in order to determine 1) their biological value for restoring the anterior cruciate ligament and 2) the ideal time and the optimal technique for surgical treatment.

Acute Disease↗
PubMed1990

Follicular thyroid adenoma: signet ring cell variant.

An unusual case of a microfollicular adenoma of the thyroid gland with signet-ring cells in a 36-year-old euthyroid man is described. Mucin stains demonstrated the presence of mainly neutral glycoproteins with focal participation of acidic groups. Immunohistochemical staining for thyroglobulin was strongly positive. The apparent "mucin secretion" described in these rare neoplasms could be due to the histochemical staining of carbohydrate components or breakdown products of thyroglobulin and colloid. The published work on primary mucin secreting tumors of the thyroid gland is reviewed.

Adenoma↗
PubMed1990

Echinococcosis of bone: clinico-laboratory findings and differential diagnostic problems.

Twenty cases of echinococcosis affecting the skeleton are reported. These cases were diagnosed at the Pathology Department of KAT General Hospital over a 12 year period (1976-1988). The parasitosis involved individual bones or skeletal parts (spine 6, pelvis 6, femur 4, tibia 1, scapula 2 and maxilla 1). The age of the patients ranged from 20-74 years (mean age: 52 years) with preponderance of men. The diagnostic and differential diagnostic problems as well as the therapy and prognosis of this infestation are discussed.

Adult↗
PubMed1989

A combined immunohistochemical and histochemical approach on the differential diagnosis of giant cell epiphyseal neoplasms.

The histological similarities and the common localization are the main causes of difficulties concerning the differential diagnosis between giant cell tumor of bone and chondroblastoma. The purpose of the present study was to detect whether histochemistry and/or immunohistochemistry could help to make the distinction between these two entities easier. The study was based on cases of chondroblastoma and giant cell tumor of bone from patients in the 2nd and 3rd decades of life. Histochemical detection of special intracellular and extracellular components (glycogen, glycosaminoglycans) as well as immunohistochemical investigation using various tumor markers (S-100, NSE, a-1-ACT, lysozyme, fibronectin) were performed on parallel paraffin sections. The presence of abundant intracytoplasmic glycogen granules and the immunoreactivity of the cells of chondroblastoma with S-100 and NSE, together with the presence of acidic sulfated glycosaminoglycans in the stroma, could help the differential diagnosis of this tumor from giant cell tumor of bone.

Adolescent↗
PubMed1989

The contribution of immunohistochemistry to the differential diagnosis of primary and metastatic neoplasma of the central nervous system (CNS).

A series of 146 primary and metastatic neoplasms of the CNS were studied with a panel of monoclonal and polyclonal antibodies. The purpose of the study was to evaluate whether immunohistochemistry can help in the differential diagnosis and facilitate a more precise classification of CNS tumors. Neoplastic cells in glial tumors (astrocytomas, ependymomas, oligodendrocytomas) reacted strongly with GFAP. Immunoreactivity with antibodies to neurofilaments helped to distinguish neuronal tumors. Keratin was always positive in metastatic carcinomas, while vimentin positivity characterized mesenchymal differentiation. Other markers such as LCA, S-100, alpha-1-antichymotrypsin, factor VIII, CEA and EMA were variably expressed by tumor cells providing information about cell differentiation and functional status.

Central Nervous System Diseases↗
PubMed1988

S-100 protein and neuron specific enolase immunoreactivity of normal, hyperplastic and neoplastic chondrocytes in relation to the composition of the extracellular matrix.

S-100 protein and neuron specific enolase (NSE) are no longer considered as specific cell markers indicating a neural origin. Since most of the cells displaying immunoreactivity for both markers also elaborate a stroma rich in chondroid or myxoid mucosubstances, we undertook the present study in order to clarify whether or not the positive immunoreaction is related to the composition of stromal glycosaminoglycans. The study was based on formalin fixed, paraffin embedded material comprising adult resting cartilage, reactive or hyperplastic cartilage, as well as benign and malignant chondroblastic tumors. Histochemical and immunohistochemical methods were applied on parallel sections with the following results: A positive immunoreactivity of the cartilage cells was always found to be related to the participation of chondroitine sulfate A and C in the stromal glycosaminoglycans. A NSE positive reaction was found in all cartilage cells displaying the characteristics of metabolically active cells. It is postulated that S-100 protein, as a calcium binding protein, might be involved in the cellular control mechanisms regulating the glycosaminoglycans-collagen interactions.

Cartilage↗
PubMed1987

Osteoma of the tongue.

A rare case of osteoma of the tongue is reported. It occurs most commonly in females in the third and fourth decades, is usually pedunculated and located on the dorsum of the tongue immediately posterior to the foramen caecum. Following surgical removal, recurrence has not been reported. The aetiology and pathogenesis remain obscure.

Adult↗
PubMed1987

Intestinal spirochaetosis. Light and electron microscopic study.

24 cases of colon spirochaetosis have been studied by light and electron microscopy. This condition, although rarely diagnosed because of the absence of special clinical symptoms, seems to be a rather frequent histologic finding with marked variation in its geographical incidence. In our material the incidence of spirochaetosis was 16.5%, almost double than in Great Britain.

Adult↗