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Biomedical subjects

S Marriner

Publications and source records attributed to S Marriner.

6 recordsLinked to original sources
PubMed1988

Comparison of ivermectin, oxfendazole and levamisole for use as anthelmintics during the periparturient period in sheep.

Ewes synchronised with progestin impregnated sponges to reduce the spread of lambing were treated during the periparturient period with anthelmintic. The suppression of nematode egg output in faeces was measured in ewes given ivermectin either by subcutaneous injection or orally, or oxfendazole or levamisole orally. Ivermectin and oxfendazole reduced the output of eggs in the faeces of the ewes significantly (P less than 0.05) and the period of suppressed egg output was extended when ivermectin was given by subcutaneous injection. Plasma pepsinogen activity was estimated as a measure of abomasal damage. Pepsinogen values were significantly (P less than 0.001) lower in those animals treated with ivermectin by subcutaneous injection than in control animals. Levamisole showed a poorer response in terms of the output of eggs in faeces than either ivermectin or oxfendazole.

Administration, Oral↗
PubMed1985

Albendazole--objective evidence of response in human hydatid disease.

Thirty-two patients with cysts caused by Echinococcus granulosus were treated with albendazole in a dosage of 10 mg/kg/day. Reversible abnormalities in liver-cell function tests were seen in five patients. Some radiological evidence of remission (on serial computed tomographic or ultrasound scanning) was seen in 15 of 22 patients undergoing a therapeutic course of albendazole (as opposed to those treated before or after surgery). In five patients, the cysts virtually disappeared. Apart from reduction in size, the appearance of a halo around the cysts and the apparent disappearance of daughter cysts has been seen. Serological findings have not correlated well with radiological or clinical improvement. Serum and cyst concentrations of albendazole sulfoxide (the principal metabolite) have been measured.

Adolescent↗
PubMed1980

Analysis of benzimidazoles in body fluids by high-performance liquid chromatography.

A simple assay for benzimidazole in plasma and GI fluids using high-performance liquid chromatography was developed. The benzimidazoles were extracted using ether and were chromatographed with methanol-ammonium carbonate mixtures as the eluting solvents. Benzimidazole was detectable in 4 ml of plasma or GI fluid to a limit of 20 ng/ml.

Animals↗