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Biomedical subjects

S Mashimo

Publications and source records attributed to S Mashimo.

68 records · Page 4Linked to original sources
PubMed1985

[A clinical study of renal cell carcinoma].

Eighty two cases of renal cell carcinoma, treated at our Department between July, 1971 and May, 1984, are reviewed. The highest incidence of this disease was seen in the 5th decade and the average age of the patients was 58.8 years. Male patients predominated over the female patients, the ratio being 1.6: 1. According to Robson's classification, thirty eight cases were in stage I, five cases in stage II, nine cases in stage III and thirty cases in stage IV. The overall survival rate at one, three and five years was 77, 58 and 48%, respectively. The most common symptom was macroscopic hematuria, followed by asymptomatic, lumbago and palpable mass. The site of distant metastases was most frequently in the lung, followed by the bone, liver and lymph node. There were no remarkable differences in the prognosis of stage I patients, between the group treated with preoperative renal arterial embolization and non-treated group. No remarkable difference was seen between the survival rate of the stage IV patients treated by nephrectomy and these not treated by nephrectomy. Renal arterial embolization was an effective therapeutic measure for patients with non-resectable stage IV renal cell carcinoma (p = 0.0647, compared with non-treated group).

Adult↗
PubMed1980

Use of polaroid film in intraoperative renal radiography: a new technique.

A new intraoperative renal radiography technique using Polaroid film is presented. The quality of the Polaroid radiograph is satisfactory enough to visualize radiopaque calculi and provides good information on the localization of intrarenal calculi in a short time. The time required for photographic development is 15 seconds and a dark room is not necessary.

Humans↗
PubMed1980

Lymphocyte stimulation by allogeneic tissue cells in rats: with special reference to differential survival of skin and kidney allografts.

The ability of isolated skin and kidney cells to activate allogeneic lymphocytes in vitro was studied in the MHC-identical and incompatible rat strains. The preparation of these cells and optimal culture conditions were summarized. 3H-thymidine uptake was strongest with skin epidermal cells and weakest with kidney cells. The results obtained from fractionated cells indicated that both Langerhans (Ia positive) and other cells (Ia negative) of the skin epidermis stimulated lymphocytes equally well and that only glomerulus and whole kidney cells stimulated, whereas cells fom the medulla and cultured epithelium failed to do so. It was suggested that skin epidermal cells possess lymphocyte-activating antigens other than Ia antigens that may be responsible for MHC-identical graft rejection. The weaker reaction by kidney cells and the limited localization of lymphocyte-activating determinants suggest that kidney cells may not express specific alloantigens detectable by the procedure employed; these cells obviously carry only a limited amount of Ia antigens.

Animals↗
PubMed1976

The mixed kidney cell-lymphocyte reaction in rats.

Optimal conditions for obtaining the proliverative response in mixed kidney cell-lymphocyte culture (MKLC) have been determined in rats. The addition of 2-mercaptoethanol to the culture medium was essential for successful stimulation of lymphocytes by allogeneic kidney cells. Proliferative responses by standard MLC and MKLC were compared in rats with the same or a different Ag-B locus. In most strain combinations, there was a significant correlation between MLC and MKLC reactions, However, the DA-ACI combination, compatible at the Ag-B locus, consistently showed negative MLC and positive MKLC reactions. This suggested the possibility that this technique allowed the expression of kidney specific antigens.

Animals↗
PubMedDate not supplied

Microwave dielectric study on hydration of moist collagen.

Two dielectric relaxation peaks were found in moist collagen by the time domain reflectometry. The low-frequency peak around 100 MHz moves little as the water content is varied. Its relaxation strength depends on the content and vanishes for completely dried collagen. This process is concluded to be due to water molecules strongly bound to the tropocollagen. Amount of the bound water is estimated as 0.12 g water/g collagen. Twenty-one water molecules are bound to one repeat of the triple helix. The existence of stringlike water chains is suggested. If the water content is less than 0.5 g water/g collagen, the high frequency peak locates between those of bound and bulk water. Water among the tropo-collagen is weakly bound to the collagen. In the higher region it does not change much with the content, being close to that of bulk water. The bulk water appears in this region.

Animals↗