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Biomedical subjects

S Mathes

Publications and source records attributed to S Mathes.

9 recordsLinked to original sources
PubMed2001

Cytologic and DNA-cytometric early diagnosis of oral cancer.

OBJECTIVE: The aim of this prospective study was to report on the diagnostic accuracy of conventional oral exfoliative cytology taken from white-spotted, ulcerated or other suspicious oral lesions in our clinic. In addition we checked DNA-image cytometry as an adjuvant diagnostic tool. Our hypothesis is that DNA-aneuploidy is a sensitive and specific marker for the early identification of tumor cells in oral brushings. STUDY DESIGN: 251 cytological diagnoses obtained from exfoliative smears of 181 patients from macroscopically suspicious lesions of the oral mucosa and from clinically seemingly benign oral lesions which were excised for establishing histological diagnoses were compared with histological and/or clinical follow-ups of the respective patients. Additionally nuclear DNA-contents were measured after Feulgen restaining using a TV image analysis system. RESULTS: Sensitivity of our cytological diagnosis on oral smears for the detection of cancer cells was 94.6%, specificity 99.5%, positive predictive value 98.1% and negative predictive value 98.5%. DNA-aneuploidy was assumed if abnormal DNA-stemlines or cells with DNA-content greater 9c were observed. On this basis the prevalence of DNA-aneuploidy in smears of oral squamous cell carcinomas in situ or invasive carcinomas was 96.4%. Sensitivity of DNA-aneuploidy in oral smears for the detection of cancer cells was 96.4%, specificity 100%, positive predictive value 100% and negative 99.0%. The combination of both techniques increased the sensitivity to 98.2%, specificity to 100%, positive predictive value to 100% and negative to 99.5%. CONCLUSIONS: Brush cytology of all visible oral lesions, if they are clinically considered as suspicious for cancer, are an easily practicable, cheap, non-invasive, painless, safe and accurate screening method for detection of oral precancerous lesions, carcinoma in situ or invasive squamous cell carcinoma in all stages. We conclude that DNA-image cytometry is a very sensitive, highly specific and objective adjuvant tool for the early identification of neoplastic epithelial cells in oral smears.

Adult↗
PubMed2000

Exhaustive soxhlet extraction for the complete removal of residual compounds to provide a nonleaching silicone elastomer.

All commercially available silicone devices contain freely diffusible silicone oils, uncured oligomers, and other impurities (such as catalysts). These residuals have been found in quantities as high as 20% by weight in commercially available silicone medical devices. The fate and effects of these residuals have been the topic of much debate recently. In this study, a method for complete removal of these residual compounds was investigated. The total amount of extractable residuals was determined through exhaustive Soxhlet extraction of 5 silicone elastomers. LIM 6030 had 6.29%, LIM 6070 had 5.74%, Q7-4750 had 3.02%, Q7-4780 had 3.22%, and SE1935 had 0.13% extractables by weight. The amount of silicon containing residuals leaching from both the extracted and nonextracted samples was also evaluated for 3 and 18 days by inductively coiled plasma (ICP) analysis. A significant amount of leachable compounds, reported as microg Si/mg solid sample, was found in all nonextracted elastomers with the exception of SE1935 compared to blanks. The amount of leachable compounds found in the extracted elastomers was not found to be significantly higher than the amount found in the blanks. The residual compounds in silicone elastomers may be completely removed by exhaustive Soxhlet extraction and the resulting polymer does not leach silicon-containing compounds in vitro.

Biocompatible Materials↗
PubMed1996

Projection on projective techniques = pathology: the problem that is not being addressed.

A replication of the "levels effect" and reported correlation of "projection" and "pathology" was undertaken using a selected set of Thematic Apperception Test (Murray, 1943) cards varied for ambiguity and scored for pathology and projection. The levels effect was not found for pathology in either a normal or psychiatric group, but was found for projection in the normal group. The correlation between projection and pathology was again clearly confirmed. It was concluded that failure to take into consideration the stimulus properties of the cards and the context in which the test was administered may lead to false attribution of pathology to normal test-takers.

Adolescent↗
PubMed1991

Influence of performance setting, experience and difficulty of routine on precompetition anxiety and self-confidence of high school female gymnasts.

This study examined changes in cognitive anxiety, somatic anxiety, and self-confidence as measured by the Competitive State Anxiety Inventory-2 in a sample of 50 female high school gymnasts prior to their performances at a practice session, dual meet, and district championship meet. The purpose of the study was to examine (1) the relationship between state anxiety and performance setting, (2) experience, and (3) difficulty of the movement task. Analysis showed that at the dual meet athletes experienced significantly greater cognitive and somatic anxiety and lower self-confidence than at the practice or district championship. State anxiety did not vary significantly with the athletes' over-all experience or the difficulty of the routines they performed. The unexpected finding that the dual meet was the most anxiety-provoking was attributed to the greater uncertainty of outcome in a competition and the fact that the dual meet occurred early in the season.

Adolescent↗
PubMed1990

A study of the relationship between blood flow and bacterial inoculation in musculocutaneous and fasciocutaneous flaps.

Regional nutrient blood flow to musculocutaneous and fasciocutaneous flaps was studied in dogs using 15-microns radiolabeled microspheres, and correlations to bacterial inoculation into closed wound spaces were sought. During the 6-day study period, no differences were found between blood flow to noinoculated versus inoculated flaps. Comparisons of blood flow to the deep surfaces of the flaps showed that blood flow to muscle in musculocutaneous flaps increased rapidly during the first 24 hours and then plateaued, while that to subcutaneous tissue plus fascia in fasciocutaneous flaps demonstrated a gradual and steady increase. The most rapid decline in bacterial counts at the undersurface of both flaps occurred within 24 hours, dropping significantly lower within musculocutaneous flaps. In addition to such surface properties of muscle as tissue ingrowth, rapid early augmentation of muscle blood flow may be largely responsible for superior bacterial suppression observed beneath musculocutaneous flaps.

Animals↗
PubMedDate not supplied

[Complications of allogeneic microsurgical transplantation of a limb (composite tissue), in rats].

PURPOSE: To analyze the composite tissue vascularized allotransplantation post operative complications and to identify factors associated with agents toxicity. METHOD: The study was done across a strong histocompatibility barrier using 39 Brown-Norway rats as donors and 78 Fischer 344 as hindlimb allotransplantation recipients treated with cyclosporine and RS-61443. RESULTS: 1 (1/78: 1.28%) was eliminated owing to thrombosis; 2 (2/78: 2.56%) owing to enteritis; 1 (1/78: 1.28%) owing to autophagia and 8 (8/78: 10.42%) died owing to undiscovered cause. CONCLUSION: Among 78 (78/78: 100%) rat limb vascularized allotransplantations, 12 (15.5%) rats died or were eliminated because of acute postoperative complications that were not related to rejection, to immunosuppressive toxicity or to opportunistic infection.

Animals↗