PubMed Health⌕ Search

Biomedical subjects

S May

Publications and source records attributed to S May.

84 records · Page 5Linked to original sources
PubMed1985

The effect of retinoids on CFU-GM from normal subjects and patients with myelodysplastic syndrome.

Five retinoid analogues differ in their effects on the growth of CFU-GM from normal human marrow. At concentrations above 10(-6) M all have inhibitory activity. This is maximal with 13-cis-retinoic acid. At lower concentrations the effect of retinoids is usually to reduce clone size rather than clone numbers though 10(-8)-10(-7) M etretinate increases clone size. The incubation of marrow cultures in the presence of 10(-6) M all-trans retinoic acid showed that in normal subjects colony counts are never reduced to less than 45% of the control value and total clone counts to less than 70% of the control value. In cultures from patients with myelodysplastic syndrome 20 out of 34 cases showed a greater inhibition of colony numbers than normal and 14 out of 35 cases showed a greater reduction in total clone numbers than normal. The results suggest that CFU-GM from some patients with myelodysplastic syndrome may have a greater sensitivity than normal to the inhibitory effect of retinoic acid.

Adult↗
PubMed1984

Family environments of depressed outpatients.

The present study assessed the family environments of 43 depressed patients treated in an outpatient clinic. All family members 11+ years of age were administered the Family Environment Scale. Results showed that perceptions of the family environment were not statistically different from a normative sample. Differences among unipolar, bipolar and secondary affective disorder groups also did not attain statistical significance. On the other hand, current symptomatology among patients was associated with negative perceptions of the family environment.

Adult↗
PubMed1983

Response of an abdominal aortic thrombotic occlusion to local low-dose streptokinase therapy.

Local low-dose streptokinase infusion (5000 to 6000 IU/hr) as compared to systemic streptokinase infusion (loading dose 250,000 IU/hr, maintenance dose 100,000 IU/hr) successfully relieved a total thrombotic abdominal aortic occlusion. No complications of bleeding or distal embolization occurred during streptokinase therapy, which required only 8 days of hospitalization. When seen at 4 months after streptokinase infusion, the patient was still free of symptoms. When no immediate threat of ischemic limb loss exists, streptokinase may offer a promising therapeutic alternative to surgical intervention for patients who represent a poor operative risk.

Aorta, Abdominal↗
PubMed1981

Mutagenic reaction products of aqueous chlorination of catechol.

Aqueous chlorination of catechol (4 and 8 mM) at varying reagent ratio has been shown to produce high mutagenicity with the Ames Salmonella strain TA100. The mutagenicity peaks at 3 equivalents of chlorine per mole of catechol. But the mutagens are unstable in neutral and alkaline solutions. Substituted catechols produce less mutagenic solutions than catechol on aqueous chlorination. If the chlorine is replaced with equivalent chlorine dioxide very little mutagenicity is produced. Among the reaction products are chlorinated catechols; all of these were synthesized, none was mutagenic but some were toxic. The sample oxidation products, o-benzoquinone and chloro-o-benzoquinone, have been identified and through synthesis were proven to be mutagenic. Some possible ring fracture products also become mutagenic after reaction with aqueous chlorine. Catechol and other simple phenolic substrates are model compounds for the aqueous reaction of chlorine with wood pulp, sewage water and potable water.

Catechols↗
PubMedDate not supplied

CT-guided transthoracic needle biopsy.

CT-guided biopsy of pulmonary and mediastinal lesions is safe and effective. It is most valuable in those cases in which fluoroscopic guidance is not possible due to resolution or anatomic consideration. CT guidance permits puncture of lesions as small as 0.5 cm, typically not seen fluoroscopically. Sensitivity of biopsy in malignant lung lesions in our series of 83 cases was 92%. Pneumothorax is the most frequent complication (10-60%) and requires chest tube insertion in 5-15% of patients.

Biopsy, Needle↗