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Biomedical subjects

S McGuigan

Publications and source records attributed to S McGuigan.

11 recordsLinked to original sources
PubMed1998

Mortality in people with learning disability: risks, causes, and death certification findings in London.

Two thousand people with learning disabilities registered as service users in two London districts were followed up for 8 years to ascertain, in those who died, age and cause of death and significant associations with early death. Respiratory disease was documented as the leading cause of death in 52% of the study population compared with only 15% of males and 17% of females in the whole population. People with learning disabilities have an increased risk of early death. Although the majority of deaths (83%) in the whole population occur in people aged 65 years and over, less than 50% of deaths in the study population were in this age group, and the risk of dying before the age of 50 was 58 times higher than in England and Wales generally. Early death was significantly associated with cerebral palsy, incontinence, problems with mobility, and residence in hospital. Death certificates were not found to be a reliable source of data about factors contributing to cause of death, and learning disabilities were rarely mentioned. The authors recommend an extension to the current format of the Medical Certificate of Death to include recording of chronic disabling conditions.

Adolescent↗
PubMed1997

Sociopsychological factors in women with chronic pelvic pain with and without pelvic venous congestion.

Social and psychological factors have long been proposed as being of importance in a sizeable subgroup of women complaining of unexplained chronic pelvic pain (CPP). The aim of this study was to examine this in two subgroups of CPP patients, thereby eliminating pain alone as the determining variable. Consecutive attenders at a clinic for CPP were assessed on a range of somatic, historical, social, and psychological variables using detailed interviews and questionnaires. They were subsequently allocated to one of two groups, based on the presence or absence of pelvic venous congestion (PVC). Significant associations emerged between some social arrangements, paternal parenting, and patterns of hostility in the group with pelvic venous congestion. The groups also differed in patterns of family illness, and the congested group tended to report more childhood sexual abuse (CSA). Clear case definition in CPP is important. In the subgroup with pelvic venous congestion early social experience may play an important role. Father-daughter relationships may be particularly relevant. Hostility patterns may influence the development of the condition. CSA does not appear to play a specific role in all unexplained CPP cases, but may have relevance for the subgroup with pelvic venous congestion.

Adolescent↗
PubMed1996

A comparison of slit-lamp supported versus hand-held biometry.

Biometry allows determination of the final refractive outcome following cataract extraction with intraocular lens implantation. We compared the accuracy of axial length measurement performed with the slit-lamp supported biometry probe versus a hand-held technique. The two methods of biometry were performed on 32 patients undergoing endocapsular cataract extraction with lens implantation. One of the methods was selected at random in order to predict implant power for a desired refractive outcome using the SRK-T formula. There was no difference in 'within-subject' variance of axial length measurement between the two methods (t = 1.74, p = 0.091), and there was no difference in refractive outcome when the power calculations for the two techniques were compared (t = 0.12, p = 0.906). The hand-held technique provides a useful alternative method of biometry in 'difficult' patients.

Biometry↗
PubMed1994

Anorexia nervosa: change over time in age of onset, presentation and duration of illness.

The question as to whether anorexia nervosa as an illness has transformed itself was partially addressed in an investigation into the possible change over time in age of onset, age of presentation and the derived variable, delay between onset and presentation. These three variables were examined in 827 patients diagnosed as suffering with anorexia nervosa, who had attended the Eating Disorders Unit at the Middlesex and St George's Hospitals from 1960 to 1990. This analysis revealed a stable age of onset but a lengthening in duration of illness and associated increase of age at presentation. However, investigation of data obtained from two other tertiary referral centres revealed stability of all three variables over time. The overall conclusion was that there has been no change in the age of onset of anorexia nervosa during the past 30 years. The increasing delay in presentation to the eating disorders clinic is most likely attributable to a change in the practice of patient referrals to a national tertiary referral centre.

Adolescent↗
PubMed1994

Plasma granulocyte-colony stimulating factor concentrations ([G-CSF]) in the early neonatal period.

We studied G-CSF concentrations ([G-CSF]) at birth and their relationship with neutrophil count, incidence of infection, gestational age, labour, and the presence of maternal pregnancy-induced hypertension. Plasma [G-CSF] were significantly elevated in babies with suspected infection and in those of hypertensive mothers, compared to healthy babies delivered by elective caesarian section (median [range] = 3101 [75- > 5000] pg/ml and 153 [45-857] pg/ml versus 32 [11-266] pg/ml; P < 0.0001); and were unrelated to neutrophil count and gestational age. Initial high concentrations (> 100 pg/ml) declined by 7 d (P < 0.0001).

Aging↗
PubMed1994

Psychiatric disorder in deaf and hearing impaired children and young people: a prevalence study.

Psychiatric screening questionnaires for deaf children and adolescents were piloted in a group of 62 children, aged 11-16 years, attending a residential school. The questionnaires, Parent's Checklist (PCL) and Teacher's Checklist (TCL) were then used to screen a group of 93 children attending one Deaf School and three Hearing Impaired Units (HIU). Psychiatric assessments were conducted with a highly structured diagnostic interview, the Child Assessment Schedule (CAS). The interview with signing deaf children was conducted with a sign language interpreter. The prevalence of psychiatric disorder in the whole group was 50.3%, 42.4% in the group attending the Deaf School and 60.9% for the group attending the HIUs. An aetiological model of psychiatric disorder in this group is proposed.

Adolescent↗
PubMed1993

The relationship between clinical classification of cataract and lens hardness.

'Hardness' of the cataractous lens is one of the major factors influencing the suitability of a patient for phacoemulsification. Surgeons should be able to estimate hardness when choosing patients for this method of cataract extraction. The aims of the study were to investigate the relationship between the clinical appearance of cataracts and their hardness. Ninety-one lenses were studied from patients undergoing endocapsular cataract extraction. Lenses were assessed using a classification based on the Lens Opacities Classification System II and hardness was assessed using an automated lens guillotine. The degree of nuclear sclerosis and the age of the patient were found to influence lens hardness. Regression analysis showed that 56% of the variation in hardness could be explained in terms of age and the degree of nuclear sclerosis. The presence of posterior subcapsular and cortical cataract did not influence hardness. These findings confirm our clinical suspicions and enable surgeons to make a more objective analysis of hardness prior to phacoemulsification.

Adult↗
PubMed1993

Psychosocial aspects of chronic pelvic pain, with special reference to sexual abuse. A study of 164 women.

Patients with chronic pelvic pain attending a tertiary referral centre show certain social, developmental and psychological characteristics. Specifically, they appear to have fewer children and to report more paternal overprotection, and a trend towards low maternal care compared to normals. They also show more depression, free-floating anxiety and somatic anxiety than such populations. The levels are similar to those found in other outpatient populations presenting with migraine or irritable bowel syndrome. Hostility levels are greater than those in normal subjects. Overall the present patient population reports the same degree of childhood sexual abuse as do many other female clinic and community sample populations. Sexual abuse is unlikely to be a specific aetiological factor in the development of chronic pelvic pain though it may yet be found to be important in subsets of the population.

Adolescent↗
PubMed1993

A controlled trial of home-based acute psychiatric services. II: Treatment patterns and costs.

Treatment records of 94 patients treated in an experimental home-based psychiatric service and 78 control patients in standard care were collected over one year. There was a substantial reduction in in-patient care in the experimental group, both in terms of proportion admitted and duration of admissions, despite similar out-patient and general practice care. The total treatment costs were significantly larger (> 50%) for standard care when controlled for by diagnostic grouping. Costs were further examined by including all specialist psychiatric care, and by excluding patients with primary diagnoses of brain damage or alcoholism. Sensitivity analysis explored the effects of increasing the cost of home visits. The relative cost effectiveness of the experimental service persisted. Clinical and social outcome was similar in control and experimental groups.

Adolescent↗
PubMed1992

Asthma and employment in young adults.

BACKGROUND: Little is known about the effect of asthma on employment. The relation between employment history at the age of 23 years and a history of asthma or wheeze was investigated in a controlled prospective study using data collected in the National Child Development Study, a longitudinal survey of all children born in the United Kingdom in one week in March 1958. METHODS: Information about subjects' medical condition was collected at four ages (7, 11, 16, and 23 years) for the original cohort of 17,319 births. At 23 years information about employment and education was obtained for 12,534 subjects (72%), of whom 460 (4%) had current asthma or wheeze, 2758 (22%) had past asthma or wheeze, and 5161 (41%) had never had asthma or wheeze. The remaining subjects could not be classified accurately. RESULTS: The risk of unemployment was higher in subjects with a current history of asthma or wheeze (odds ratio 1.32, 95% confidence interval (CI) 1.09-1.61) or a past history of asthma or wheeze (odds ratio 1.54, 95% CI 1.27-1.85) than in those with no such history, after subjects' sex, region of birth, maximum educational qualification, and father's social class had been controlled for. Current and past asthma or wheezing illness predicted a worse employment history in terms of most of the outcomes examined, including mean percentage of months employed since leaving school, mean number of months in current full time job, mean percentage of months unemployed since leaving school, likelihood of being out of the labour force owing to long term illness, and the proportion attaining social groups 1-3. The differences from those who had never had asthma or a wheezing illness were, however, small and generally non-significant. CONCLUSION: Asthma has only a small adverse effect on employment in young adults.

Adult↗