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S Melander

Publications and source records attributed to S Melander.

At least 19 recordsLinked to original sources
PubMed1992

Seborrheic keratoses and cancer.

BACKGROUND: The eruptive appearance of numerous seborrheic keratoses, the sign of Leser-Trélat, has been regarded as a reliable cutaneous marker of internal malignancy. OBJECTIVE: We have evaluated the possible association of malignant disease and the sign in 1752 consecutive cases of seborrheic keratoses. METHODS: First, the Swedish Cancer Registry was searched for records of malignancies in the study population (1958 to 1984), and the expected number of malignancies was calculated. Second, records of persons with malignancy within 1 year before or after the diagnosis of seborrheic keratosis were checked for the sign of Leser-Trélat. Third, a case control study was performed to evaluate the possibility of eruptive seborrheic keratoses among the noncancer patients in the study population. RESULTS: The results showed a slight increased risk of cancer in the study population (relative risk = 1.2; 95% confidence interval = 1.0 to 1.3), mainly because of an increased risk of cutaneous squamous cell carcinoma. In 62 patients with seborrheic keratoses, a malignancy (excluding skin) was diagnosed within 1 year before or after the diagnosis of seborrheic keratosis. Of these 62 patients, 6 were regarded as possibly having presented with the sign of Leser-Trélat. For every one of the 62 cases with seborrheic keratosis and malignancy within one year, an age- and sex-matched control patient without cancer was selected from the study population and the records were checked for sudden and eruptive seborrheic keratoses. Among the control patients, five were regarded as possibly having presented with the sign of Leser-Trélat. CONCLUSION: This study gives no evidence to support the opinion that eruptive seborrheic keratoses are related to internal cancer risk.

Adolescent↗
PubMed1983

Colorectal endometriosis.

Endometriosis is a common disease occurring in about 10% of all women. Involvement of the gastrointestinal tract is not infrequent and endometriosis should therefore be considered in the differential diagnosis of colon lesions in women of childbearing and middle age. Colorectal endometriosis may cause obstructing symptoms difficult to distinguish from malignant or inflammatory disease, as is demonstrated by 6 case reports. Colorectal endometriosis is mostly localized to the sigmoid or the anterior rectal wall with extramucosal radiologic appearance and is difficult to diagnose by sigmoidoscopy. Patients with an infiltration of the anterior rectal wall (shelf tumour) should undergo a complete evaluation including laparoscopy before surgery is considered. Bowel resection often offers the best chance of cure.

Adult↗
PubMed1978

Trophoblastic pseudotumour of the uterus. A case report.

A 52-year-old woman with vaginal bleedings had hysterectomy because curettings prompted suspicion of malignancy. A uterine tumour with deep infiltration of trophoblastic cells in the myometrium was revealed. Postoperative quantitative analysis for urinary human choriongonadotropin gave 1500 IU/1. The patient got no other treatment and is well 3 years after operation. The histopathological picture and the clinical course were consistent with the recently introduced diagnosis of benign "trophoblastic pseudotumour", which should perhaps replace the old terms "syncytioma" and "chorionepitheliosis".

Diagnosis, Differential↗
PubMed1978

Studies on toxemia of pregnancy with special reference to blood pressure. I. Incidence and some characteristic features of the mothers and infants.

An investigation was made of 150 women who were diagnosed at the Department of Obstetrics and Gynaecology, University Hospital, Uppsala in 1964-68 as having toxaemia of pregnancy. Eleven had eclampsia and the remainder pre-eclampsia. Toxaemia occurred in 0.88% (average) of all parturients during the study period. Some characteristics of the mothers and their infants are reported. Thus, there were more instrumental deliveries in the toxaemia group than in the non-toxaemic patients delivered in the clinic. The maternal weight at delivery was also greater in the toxaemia group. The frequency of complications among the infants was higher in the group with toxaemia. There were more stillbirths, lower birth weights and more congenital malformations. With regard to blood pressure, almost identical pressures were noted in the eclamptic and pre-eclamptic groups, with one exception. The maximum blood pressure recorded during delivery was higher in the eclamptic than in the pre-eclamptic group (198/127 and 175/117).

Birth Weight↗
PubMed1978

Studies on toxaemia of pregnancy with special reference to blood pressure. II. Results after 6-11 years' follow-up.

One hundred and fifty women with a diagnosis of toxaemia of pregnancy treated in the Department of Obstetrics and Gynaecology, University Hospital, Uppsala between 1964 and 1968 were investigated. One hundred women were still living in the area in 1975 and thus could be restudied. The participation rate was 100% in this group. After this follow-up period of 6-11 years 17 women were hypertensives at the investigation and 12 were already on antihypertensive therapy. The incidence of hypertension was thus 29%. The toxaemic women who had developed gypertension showed a higher frequency of a family history of hypertension as well as of cardiovascular lesions than the toxaemic women with normal blood pressures at follow-up. At the time of the toxaemia the future hypertensive women (n=29) had a higher blood pressure on admission, as well as a greater body weight, than the women who were normotensive at the follow-up investigation. Forty-six of the 100 re-studied women were taking contraceptive pills. Seven developed hypertension while 'on the pill'. Four of these became normotensive after discontinuating the pill.

Blood Pressure↗
PubMed1973

Perinatal mortality.

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Abortion, Spontaneous↗