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Biomedical subjects

S Merin

Publications and source records attributed to S Merin.

At least 37 records · Page 2Linked to original sources
PubMed1983

Electrophysiologic tests in assessment of senile macular degeneration.

Twelve patients with macular disease were studied. Mean age at the beginning stages of the disease was 61.75 years. They were examined by biomicroscopy, fluorescein angiography, and electrophysiological tests (ERG, EOG, VEP). No relevant correlation could be found between the routinely administered and evaluated ERG and EOG tests and the clinical stage of the disease. The VEP proved a more sensitive means of evaluating macular function in our patients. The possibility of the VEP's being of prognostic importance is raised.

Aged↗
PubMed1982

Do sex, ethnic origin or environment affect myopia?

The degree of myopia was investigated in males and females from the same ethnic group who were raised in the same environment, in subjects from the same origin who were raised in extremely different environments, and in subjects coming from different ethnic groups. No statistically significant differences were found between these groups. Most probably the degree of myopia is not influenced just by sex or ethnic origin or environmental conditions.

Adult↗
PubMed1982

Combined vitamin A and E therapy prevents retinal electrophysiological deterioration in abetalipoproteinaemia.

Eight patients with abetalipoproteinaemia had the typical ocular, systemic, and laboratory findings of this disease. Combined therapy with vitamins A and E was administered, starting as early as the first day of life and as late as 26 years of age. The patients were followed up for 2-6 years. Electroretinography was undertaken in all cases and electrooculography in some. After initiation of vitamin A and E therapy no progression of disturbed visual function could be detected in any patient. These objective tests of retinal function demonstrated that the combined vitamin A and E therapy may be useful in arresting retinal deterioration in abetalipoproteinaemia.

Abetalipoproteinemia↗
PubMed1981

Myopathy in hyperornithinemic gyrate atrophy of choroid and retina.

Five patients in two families with hyperornithinemia and gyrate atrophy (HOGA) of the choroid and retina are reported. All patients had marked muscle wasting. Biochemical studies revealed high levels of plasma ornithine and low levels of plasma lysine. Muscle biopsies were performed in four patients and showed subsarcolemmal accumulation of pleomorphic mitochondria and tubular aggregates. These findings suggest that muscle wasting in HOGA is associated with a myopathy that is probably secondary to hyperornithinemia and/or hypolysinemia.

Adolescent↗
PubMed1980

Refractive power of premature children at infancy and early childhood.

We evaluated the refraction of 198 children born prematurely with birth-weights of 2,000 g or less, without any ocular disease. Between the ages of 6 months to 3 1/2 years these children had a mild hypermetropia. The refractive error did not change between the ages of 6 months and 3 1/2 years. The refraction of the prematurely born children was similar to that found in children born at full term.

Age Factors↗
PubMed1980

Conjunctival ultrastructure in Niemann-Pick disease type C.

A 5-year-old girl with Niemann-Pick disease type C had normal eyes but the conjunctival ultrastructure was abnormal. Lamellar cytoplasmic bodies, characteristic of Niemann-Pick disease, were found in epithelial cells, stromal fibroblasts, endothelial cells, and pericytes of the stromal capillaries. The basement membrane of the capillaries was multilayered. The Golgi apparatus was unusually well developed. The combination of ocular findings and conjunctival ultrastructure may be helpful in the differential diagnosis of Niemann-Pick disease and its subtypes.

Child, Preschool↗
PubMed1980

Brittle cornea, blue sclera, and red hair syndrome (the brittle cornea syndrome).

A syndrome of red hair, blue sclera, and brittle cornea with recurrent spontaneous perforations is presented in 2 siblings of a Tunisian Jewish family. The genetic transmission of this disorder is autosomal recessive. This is the second description of this syndrome, which should be called the 'brittle cornea syndrome'. This syndrome has so far been reported only in Tunisian Jewish families.

Adolescent↗
PubMed1979

Schirmer test and break-up time of tear film in normal subjects.

We examined the precorneal film, the Schirmer test No. 1, and the break-up time tests in 440 healthy young students. There were no statistically significant differences (1) between men and women from the same origin who were brought up in the same environment, (2) between students from different ethnic origins who were brought up in the same environment, and (3) between students of the same origin who were brought up in different environments. Gradual seasonal changes in climatic factors, such as temperature, humidity, visibility, and barometric pressure, seem to have no appreciable effect on the Schirmer test No. 1 or break-up time test.

Adolescent↗
PubMed1979

Metabolic studies in two families with hyperornithinemia and gyrate atrophy of choroid and retina.

Studies on the metabolism of selected amino acids were carried out in five patients with gyrate atrophy of the choroid and retina and four obligate heterozygotes. Hyperornithinemia, hyperornithinuria, and hypolysinemia were found in all patients. In one of the patients, the condition was diagnosed as early as 4 years of age. Ornithine loadings in the affected individuals did not induce the expected elevation of plasma glutamic acid and proline. Oral lysine tolerance tests in patients resulted in (1) enhancement of the hyperornithinuria and hyperlysinuria and (2) elevation of plasma lysine levels, which were below values obtained from normal controls. Supplementation of the regular diet with lysine for a period of 1 month increased plasma lysine but had no effect on plasma ornithine concentration.

Adolescent↗
PubMed1978

Retinal ischemia (capillary nonperfusion) in diabetic retinopathy of patients with and without systemic hypertension.

In a study of 138 patients with diabetic retinopathy and good fluorescein angiograms, areas of CNP were found in 66.5% using a macular centered photograph. There was no statistically significant correlation between the appearance of CNP, their size and number with the level of systolic and diastolic blood pressures, the duration of diabetes (at the onset of diabetic retinopathy), the age at onset of diabetes, the age at examination, the control of the diabetes and the treatment of hypertension. The only borderline statistically significant difference was found between patients with constant hypertension when compared to patients with labile hypertension.

Age Factors↗
PubMed1978

Retinal ischemia (capillary nonperfusion) and retinal neovascularization in patients with diabetic retinopathy.

138 diabetic retinopathy patients with good fluorescein angiograms of the macular areas were studied. Areas of capillary nonperfusion (CNP) were surrounded by other capillary abnormalities and were often based on a larger retinal vessel. A satistically highly significant anatomical relationship was found between CNP and neovascularization. In addition, the frequency of neovascularization increased with the increase in size of CNP.

Diabetic Retinopathy↗
PubMed1978

Mucolipidosis IV: ultrastructural diagnosis of a recently defined genetic disorder.

In nine cases of a new genetic disorder mucolipidosis IV clinical findings included early or congenital corneal cloudiness and mild to severe psychomotor retardation in all patients. The diagnosis can be established by electron microscopy of the conjunctiva, which along with several other tissues shows typical ultrastructural changes. All of the known patients described were descendants of parents of Jewish-Ashkenazi origin, and it seems that mucolipidosis IV is another "Jewish" genetic disease. Prenatal diagnosis can be made by finding the typical ultrastructural changes in cells of the amniotic fluid. Biochemical abnormalities are inconspicuous, but there is evidence that the storage materials are gangliosides and hyaluronic acid.

Conjunctiva↗
PubMed1977

Retinal vein occlusion.

A brief description is given of the main clinical, histological and epidemiological circumstances of retinal vein occlusion. In an assessment of the pathogeneis of the condition, primacy is given to the role of arteriolar flow insufficiency and stress is laid on the long-standing capillaropathy which precedes the heamorrhagic phase of the disease. Basic therapeutic considerations are mentioned but stress is laid on the diagnosis of the pre-occlusive stage and on measures of a preventive nature that may be taken. Retinal vein occlusion and haemorrhagic cerebral infarct are compared with regard to their pathogenesis and the advantages are discussed of a common ophthalmoscopic study of retinal vein occlusion with neurologists interested in cerebral vascular disease leading to an interchange of therapeutic experience in both conditions. Finally, there are detailed the studies in retinal vein occlusion being conducted by the Jerusalem Institute for the Prevention of Blindness. These are studies of incidence, natural history and of pathogenesis as observed in the experimental disease produced in rhesus monkey.

Cerebral Hemorrhage↗