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Biomedical subjects

S Meryn

Publications and source records attributed to S Meryn.

64 records · Page 4Linked to original sources
PubMed1982

[Complications of the central venous feeding of mobilized patients with an all-in-one solution].

35 mobilized patients received continuous parenteral nutrition consisting of an all-in-one solution mixed together in this department right before use over a total period of 1155 days (mean per patient 33 days). The primary complication rate was: second puncture in 14%, pneumothorax in 11% and haemothorax in 3% of cases. Secondary complications: catheter-related sepsis was documented in 8.5%. Metabolic complications were not seen. The all-in-one solution is a satisfactory nutrient for long-term, low-risk administration by the route, suitable even in the case of mobilized patients, without the necessity of intensive metabolic monitoring.

Adult↗
PubMed1982

[Concomitant pancreatitis in hepatic coma].

Increased levels of serum amylase were found in 14 out of 34 patients (41%) with coma due to acute liver failure, in 8 out of 55 patients (14%) with hepatic encephalopathy, and in 5 out of 10 patients with a mixed pathogenesis. In 4 patients of the first group (11.7%) and 4 of the second group (7%) pancreatitis was diagnosed at post mortem. The pathogenesis of pancreatitis concomitant with liver failure is unclear. Virus infection and intoxication may do damage to both organs; hemodynamic factors, coagulation defects, and derangements of metabolism may play a role as well.

Acute Disease↗
PubMed1982

[Effect of parenteral nutrition on serum proteins in patients with Crohn disease].

The concentration of 19 serum proteins was determined by radial immunodiffusion in 23 patients with Crohn's disease before and after treatment with parenteral nutrition. The results were related to body weight and Crohn's Disease Activity Index. An increased serum concentration of retinol-binding protein, prealbumin, and transferrin paralleled an increase of body weight. Alpha-1-glycoprotein, alpha-2-chymotrypsin, alpha-1-antitrypsin, C-reactive protein, and haptoglobin decreased during parenteral nutrition and showed a positive correlation to the Crohn's Disease Activity Index. The determination of certain proteins is clinically useful, since their serum concentration reflects the influence of parenteral nutrition on nutritional status and disease activity. Measurement of these proteins provides a useful guide to the management of patients with Crohn's disease treated with parenteral nutrition.

Adult↗
PubMed1982

[Emergency endoscopy in patients with chronic alcohol abuse].

In this study we evaluated the findings of emergency endoscopy--carried out because of acute bleeding in the upper gastrointestinal tract--in 58 patients with chronic abuse of alcohol. These findings were compared with those bleeding sources which were seen within the emergency endoscopy of 199 patients without abuse of alcohol. Among the collective of the chronic alcoholics in 37,9% the bleeding lesion was found in the esophagus. In one third of the alcoholics with proved liver cirrhosis and esophageal varices another bleeding source than esophageal varices existed. In two patients of this collective, besides bleeding esophageal varices another more distally located bleeding source could be found. This shows the necessity to examine also stomach and duodenum in order to exclude an additional bleeding lesion, even when bleeding out of these varices is endoscopically proved. Erosive alterations in the area of the stomach and duodenum were observed very frequently when multiple lesions existed.

Alcoholism↗
PubMed1982

[Diagnosis of colitis in Behçet's syndrome (author's transl)].

A case report is given of a patient with Behçet's syndrome presenting with relapsing diarrhea and genital ulcers; similar cases from the literature are discussed. Neither the radiological nor the colonoscopic symptoms are typical in Behçet's syndrome and thus do not allow differentiating it from other forms of colitis. For that reason all forms of colitis accompanied by extraintestinal lesions, especially genital ulceration, should give rise to the suspicion of Behçet's syndrome.

Adult↗
PubMed1981

Evidence of age-dependent activity increase of poly(C)-avid-serum ribonuclease in man.

The activity of ribonuclease (E 3.1.4.22) was estimated in sera of 401 normal subjects (normal renal function, no signs of catabolism), age ranging from 16 to 100 years (mean: 50.25 +/- 19.98) with Poly (C) as substrate. Further activity was measured with the substrates Poly (U), Poly (A) and Poly (G) in 10 sera from each age decade between 21-30 years and 81-90 years. Greatest activity was found with Poly (C) as substrate (mean: 15.88 kU/l +/- 9.57). Covariant analysis (age as covariant) revealed no sex-related activity distribution at any age, whereas the age-dependent activity increase was highly significant (p less than 0.001; 11-20 years: 9.48 kU/l +/- 3.07; 81-90 years: 34.72 kU/l +/- 5.88). Activity with the other substrates was very low and constant throughout all ages. It seems to be mandatory to consider the age of the patient when interpreting ribonuclease activity.

Adolescent↗
PubMedDate not supplied

A dot-immunobinding assay for antimitochondrial antibodies.

A dot-immunobinding assay was established for the detection of antimitochondrial antibodies. Nitrocellulose strips were coated with sonicated rat liver mitochondria and incubated in the presence of human sera. The resulting immune complexes were visualized with an enzyme-linked second antibody. Antimitochondrial antibodies were found in the sera of 96% of patients with primary biliary cirrhosis, 17% of patients with autoimmune hepatitis and 4% of patients with progressive systemic sclerosis. Sera of patients with other liver diseases or with systemic lupus erythematosus, specimens positive for M1 and M3 mitochondrial antibodies and samples from normal controls were all negative. Antinuclear and other cytoplasmic antibodies were not detected in this assay. The dot-immunobinding assay for antimitochondrial antibodies is rapid and sensitive, and obviates the need for expensive equipment.

Animals↗
PubMedDate not supplied

Upper gastrointestinal endoscopy findings in patients with long-standing bulimia nervosa.

Bulimia nervosa, an eating disorder now recognized with increasing frequency, is receiving growing attention because of purported complications. Recent claims of a high frequency of erosions, ulceration, and bleeding in the esophagus, ascribed to repeated, self-induced vomiting, prompted us to investigate by endoscopy the upper gastrointestinal mucosa in 37 consecutive patients with long-standing bulimia nervosa. The endoscopic appearance of esophageal and gastric mucosa was normal in 23 patients. Signs of mild esophagitis observed in eight patients were not related to the duration or severity of bulimic behavior or to symptoms of gastroesophageal reflux; two of these eight patients had sliding hiatal hernias. The remaining six patients were found to have superficial mucosal erythema in the stomach or duodenum, but none showed actual erosions, ulcers, or bleeding. Our observations suggest that, in contrast to reports by others, mucosal injury consequent to chronic, self-induced vomiting in patients with bulimia nervosa is relatively infrequent and limited.

Adolescent↗
PubMedDate not supplied

Influence of parenteral nutrition on serum levels of proteins in patients with Crohn's disease.

Parenteral nutrition (PN) is commonly used in the management of inflammatory bowel disease. Previously we reported about the serum protein levels in Crohn's disease before and after treatment with PN; in that study we found an increase of some indicators of nutritional status and a decrease of some acute phase reactants after treatment. We have now completed the trial determining the concentration of 19 serum proteins in 25 patients with Crohn's disease before and after treatment with PN and 8 wk thereafter. The concentration of albumin, retinol-binding protein, prealbumin, and transferrin were found to rise in parallel with the body weight during PN, whereas 8 wk after treatment only albumin and transferrin showed a further significant rise. alpha-1-Glycoprotein, alpha-2-chymotrypsin, alpha-1-antitrypsin, CRP, and haptoglobin decreased during and 8 wk after PN, alpha-1-glycoprotein, alpha-2-chymotrypsin, and alpha-1-antitrypsin showed a positive correlation to the Crohn's Disease Activity Index. The serum IgM-levels were found to be significantly increased during and after PN with a negative correlation to the Crohn's Disease Activity Index. Our data indicate that PN not only improves nutritional status in the active phase of Crohn's disease during therapy but reduces the grade of inflammatory activity during and even after treatment with PN.

Adolescent↗