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Biomedical subjects

S Meurling

Publications and source records attributed to S Meurling.

At least 37 records · Page 2Linked to original sources
PubMed1983

Water and mineral balance during total parenteral nutrition.

The water balance of 10 full-term infants was investigated during postoperative total parenteral nutrition. When only the output of water in faeces, urine and vomit was taken into account the infants gained water (positive balance), 36.4 +/- 4.1 g/kg/day, with the given infusion. The total mean evaporative water loss was calculated to be 26.5 +/- 2.4 g/kg/day, which is slightly higher than that found in healthy newborn infants. When the same amounts of zinc and copper per kg body weight were given to two pre-term and to two full-term newborn infants, lower zinc concentrations were found in the serum of the pre-term infants. Negative balances of zinc were found in the pre-term infants, indicating that pre-term infants need more zinc/kg. Serum copper levels were normal in all infants.

Copper↗
PubMed1982

H-type tracheo-oesophageal fistula in children with special reference to surgical management and to repair of recurrent nerve injury.

The majority of tracheo-oesophageal fistulas are best treated by a cervical approach, in which there is an obvious risk of injuring the recurrent laryngeal nerve. Usually there is a temporary dysfunction, but if the nerve is completely divided, an attempt at microsurgical direct end-to-end anastomosis is worth while, which is here proven in a child of three weeks of age.

Esophagoscopy↗
PubMed1981

Gut structure changes in rats on continuous and intermittent complete parenteral nutrition.

Diarrhoea is often seen as a complication in infants when shifting from a few weeks of complete parenteral nutrition (CPN) to enteral feeding. In this experimental study, the intestinal structure during CPN was investigated, whereby rats received a 10-day regimen of CPN continuously or for 12 hours per day. A third groups of rats received the same regimen enterally ad libitum. The weight and nitrogen content of the intestine decreased in the intravenously fed rats. Marked mucosal changes were seen particularly in the proximal part of the small intestine, where the height of villi and the nitrogen content decreased most. The decreased height of the villi seemed to be caused mainly by a decrease in the number of mucosa cells. No obvious advantages were seen by giving the regimen for 12 hours per day.

Animals↗
PubMed1981

Growth and nitrogen utilization in rats on continuous and intermittent parenteral nutrition with and without fat (Intralipid 20%).

A rat model relevant to paediatric praxis was designed in order to evaluate possible differences between total parenteral nutrition (TPN) with fat (Intralipid 20%), and isocaloric TPN without fat and also to compare continuous TPN (24 hours/day) versus intermittent TPN (12 hours/day). TPN with fat resulted in better growth and nitrogen utilization. Continuous TPN with fat resulted in statistically significant better nitrogen utilization. The results suggest that TPN in paediatric praxis should be continuous and include fat.

Animals↗
PubMed1981

Complete parenteral nutrition in the surgery of the newborn infant.

A regimen of complete parenteral nutrition (CPN), including glucose, amino acids, fat, water- and fat-soluble vitamins and minerals, was used in 10 newborn infants operated on for gastrointestinal malformations. By giving more than 90 kcal/kg/day (376 kJ) and approximately 2.1 g amino acids/kg/day, normal weight gain and nitrogen retention were obtained. 3-Methylhistidine excretion was measured in 4 infants and a correlation to the nitrogen retention was found. Normal fat clearance rates, triglyceride and cholesterol concentrations in serum were measured in all infants except in one pre-term. One preterm infant had very low levels of zinc in serum and red cells and had clinical signs of zinc deficiency. The regimen seemed to suit full-term infants very well but it is possible that even more energy should be supplied to pre-term infants and perhaps also different amounts of trace elements.

Acid-Base Equilibrium↗
PubMed1981

Liver changes in rats on continuous and intermittent parenteral nutrition with and without fat (Intralipid 20%).

The possible advantages of including fat in a regimen of total parenteral nutrition (TPN) have long been debated. In order to investigate the role of fat in liver function during different intravenous regimens, two groups of rats received a regimen including fat (Intralipid 20%) during 12 and 24 hours/day, respectively and two groups received a fat-free regimen, isocaloric and isonitrogenous, during the same intervals, all for a period of 10 days. A control group received for 10 days the fat-including regimen orally and libitum. The liver was investigated biochemically and morphologically. Fatty infiltration of the parenchymal liver cells, a low content of linoleic acid and a high content of palmitic and oleic acid among the liver lipids were found in the rats receiving the fat-free regimen. Fat pigments in the cells of the reticuloendothelial system of the livers and values of fatty acid among the liver lipids comparable to those found in orally-fed rats were seen in rat receiving the fat-including regimen. This study underscores the physiological importance of including intravenous fat emulsion in the TPN regimen. Our results also indicate that essential fatty acid deficiency in tissue may develop rapidly.

Alanine Transaminase↗
PubMed1981

The concentrations of trace elements in blood from healthy newborn infants.

The concentrations of 14 elements in red cells and serum in 23 healthy newborn infants were determined with the aid of neutron activation analysis. Whole blood from seven mothers was also analysed. The mothers had no signs of trace element deficiency. In newborn infants the concentration of zinc in red cells was low and that of calcium was high, as compared with adults. The copper concentration in serum was low. In the newborn infants, higher ratios of intracellular to extracellular concentrations of sodium and potassium were found, as compared with adults. Iron and rubidium values in serum and red cells were similar to those found in adults. The ratio of intracellular to extracellular concentrations for chromium was two-the same value found in adults, although the levels were lower than reported in adults.

Adult↗
PubMed1981

Energy, fat and nitrogen balance in healthy newborn infants during the first week after birth.

There are limited data in the literature concerning the energy, fat and nitrogen balances in healthy newborn infants of normal weight. For this reason, five healthy newborn infants were studied during the first week after birth. Balance studies on energy, fat, nitrogen, dry matter and water were performed. Oxygen consumption was determined by an open method. The weight decrease the first days was explained by a deficit of water and energy intake. Weight gain was seen when the water intake was 80-100 ml/kg/day and the energy intake 200-300 kJ/kg/day. A linear relation was found between the total evaporative water losses and ambient vapour pressure. The mean resting metabolic rate was 174 kJ/kg/day with the range 144-200 kJ/kg/day. With higher activity the metabolic rate increased 20-45%. Positive balances of nitrogen and fat were obtained when the intakes exceeded 150 and 275 mg/kg/day, respectively.

Anthropometry↗
PubMed1976

A highly differentiated exocrine pancreatic tumour in a young boy.

A primary pancreatic tumour in a 6-year-old boy was removed by radical excision. From both light and electron microscopic observations the tumour was considered to be of exocrine origin, with some differentiation towards acinar cells. Although the tumour was highly differentiated, it was regarded as probably malignant because of tumour growth into the surrounding fibrous capsule. The case is discussed in relation to earlier rare reports of pancreatic tumours in infants and children.

Child↗
PubMed1976

Effect of highly selective vagotomy on gastric emptying.

Our objective was to study the gastric motility after highly selective vagotomy (HSV) by determining the gastric emptying rates of isotonic saline and glucose. In 15 controls and 15 patients after HSV, 750 ml of saline and glucose respectively were introduced into the stomach with an interval of two hours. Twenty minutes after each infusion had been started the content of the stomach were aspirated. Phenol red was added as a marker in order to obtain information about the amount of gastric secretion plus possible duodenal regurgitation. In the controls the mean volume of gastric contents recovered was 208 ml after saline and 539 ml after glucose. The corresponding mean volume of test meal remaining was 158 ml after saline and 465 ml after glucose. In patients after HSV the figures for gastric contents were 81 ml after saline and 303 ml after glucose and for meals remaining 59 ml after saline and 259 ml after glucose. The data indicate that HSV speeds the gastric emptying of liquids, while liquids of different compositons are still emptied at different rates, indicating the preservation of a control of the gastric emptying.

Adult↗